Dual functions of AP 1 in neuronal cell death and differentiation

... of c-Jun, c-Fos and ATF2 29 1. 3 .1. 3 Regulation of AP- 1 activity by its interacting proteins 30 1. 3.2 Role of AP- 1 in cell proliferation and differentiation 31 1.3.2 .1 Role of AP- 1 in ... AP- 1 in cell proliferation 31 1.3.2 .1. 1 AP- 1 is an important regulator in cell proliferation 31 1.3.2 .1. 2 Mechanisms of AP- 1 modulation of...

Ngày tải lên: 16/09/2015, 15:54

... suggesting that caspase- 11 is upstream of caspase- 1 and unlike caspase- 1, caspase- 11 is LPS-inducible 14 1.2 .4. 3 Caspase- 1 and Caspase- 5 Caspase- 1 is the prototype for the group of inflammatory caspases ... DN caspase- 12? Another glaring shortcoming is the lack of re-expression of caspase- 4 in the cell line lacking caspase- 4 The figures and in the...

Ngày tải lên: 13/09/2015, 19:50

... over-expression of p21WAF1 inhibits DNMT1 73 3 .1. 1.7 TSA -mediated induction of p21WAF1 results in inhibition of 76 DNMT1 3 .1. 1.8 TSA -mediated induction of p21WAF1 is independent of p53 85 3 .1. 2 Transcriptional ... between DNMT1 and p21WAF1 in the 63 cell cycle 3 .1. 1 .1 3 .1. 1.2 DNMT1 expression in the cell cycle 63 WAF1 in DNA 67 p21WAF1 68 Tran...

Ngày tải lên: 14/09/2015, 14:13

... the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence of interleukin-1β ... the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from cell death induced by pro-i...

Ngày tải lên: 09/08/2014, 07:20

... 11 3 6 .1. 4 Mutagenesis 11 3 6 .1. 5 6.2 HCT 116 and E1 cell lines 11 2 Transfection 11 4 Cell-based assays 11 5 6.2 .1 6.2.2 Wound healing 11 5 6.2.3 ... Stathmin- 1 1. 2 .1 The Stathmin family 1. 2.2 STMN1 in microtubule regulation 10 1. 2.3 STMN1 in cell cycle regulation 12 1. 2.4 STMN1 in cancer 14 ... Conclusion and future work 10 7 Chapter Materials...

Ngày tải lên: 09/09/2015, 11:25

... ROLE OF P73 IN REGULATION OF CELL DEATH: SPECIFIC ROLE IN MITOTIC CELL DEATH AND POTENTIAL REGULATION OF CASPASE- 2s TOH WEN HONG NATIONAL UNIVERSITY OF SINGAPORE 2007 ACKNOWLEDGMENT ... Up -regulation of caspase- 2S in Saos2 p73 inducible cell line and Sh5y stably expressing DNp73β 146 Fig 4.10: ChIP of p73 on 22 bp p73 binding site...

Ngày tải lên: 13/09/2015, 21:21

... to the death of neurons (Ekshyyan and Aw, 2004) 1.1.1 Types of cell death: apoptosis and necrosis Mammalian cells can die by one of several different defined pathways, the most common of which ... of all animal cell types Originally, they are thought as involved only in the digestion of cell nutrients, cell protein turnover, tissue remodeling, lysis of invaders, and a...

Ngày tải lên: 10/11/2015, 12:35

... evaluation of heme dynamics in cultured cells Role of heme metabolism in cellular heme content Regulatory role of free heme in expression of HO-1 To evaluate the contribution of heme synthesis and ... HO-1 protein was also induced by the treatment with HO-2 siRNA in HepG2 cells These results indicate that the down-regulation of HO-2 expression is...

Ngày tải lên: 19/02/2014, 05:20

... development, in particular during the differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells ... UCHL1 promoter DNA) to 11 - 13 fold in the RCC cell line MZ1851LN (strong methylated UCHL1 promoter DNA) to 11 - 18 fold in the RCC cell lin...

Ngày tải lên: 18/06/2014, 15:20

... cytotoxicity of the bacteria in biofilms is one of the adaptations that allows them to persist Previous studies indicate that deletion of the gene encoding the protein MgtE from P aeruginosa increases the ... inextricably linked A key finding of this study is that disruption of one function of MgtE does not always eliminate the other In interpreting the r...

Ngày tải lên: 24/08/2014, 11:35

... function upstream of the effector caspases in apoptosis and are known as initiator caspases A phylogenetically distinct group of 13 caspases (caspase- 1, caspase- 4, caspase- 5, caspase- 11 and caspase- 12 ) ... caspase- 1 to an influenza A/ Puerto Rico/8/34 (H1N1) virus infection of RAW264.7 murine macrophages, in vitro To investigate the role of ca...

Ngày tải lên: 13/10/2015, 16:41

... persistently HBV expressing cell line HepG2.215 and its parent cell line, a non-HBV expressing cell line HepG2 We found that cIAP1 and cIAP2 were clearly increased in the HBV expressing cells but XIAP ... expression in the HBV expressing cells was first investigated by the comparison of the gene expression profile in the HepG2.215 and HepG2 cells using gene arra...

Ngày tải lên: 02/11/2012, 11:17

... junction barrier integrity (7) Conversely, activation of atypical PKC isoforms using bryostatin instead increased the expression of claudin-1 in the tight junction complex, and increased tight ... cell motility We have previously shown that increasing the levels of CLDN-1 increases the invasion of melanoma cells (4) To determine if the increase in claudin-1 needs...

Ngày tải lên: 03/11/2012, 11:17

... for a protein secreted as a result of the cellular production of cystatin C Cellular levels of cystatin C after incubation of the cells in medium containing lm cystatin C in a timescale manner, ... immunological methods and measurement of the cysteine inhibitory capacity of cells The human cancer cell lines chosen included one epidermoid carcinoma cell line...

Ngày tải lên: 16/03/2014, 06:20