Novel biodegradable cationic core shell nanoparticles for codelivery of drug and DNA 4

... in Figure 4. 31 and Figure 4. 32 From Figure 4. 31, the CMC (I1/I3) of PEG5000-P(MDS-co-CES) in deionized water, the acetate buffer (0.02M) with pH of 5.6 and 4. 6 was 42 .7, 74. 7 and 74. 3 mg/L respectively ... encapsulation efficiency of indomethacin was 44 .8%, 48 .4% and 58.2%, and the drug loading was 10.6%, 11 .4% and 13 .4% when the micelles were fabricated...

Ngày tải lên: 16/09/2015, 15:54

... the drug and the core- forming segment cholesterol The drug- loaded micelles had suitable size for in vivo application and high zeta potential for DNA binding 5. 1.4 DNA binding ability 182 The DNA ... size of about 10 to 20 nm However, the conjugation of PEG could improve the stability of the micelles, which were designed for systemic delivery of drug and/ or...

Ngày tải lên: 16/09/2015, 15:54

... set at 4.5 nm The ratios of the peak intensities at 33 8 nm and 33 3 nm (I 338 /I 333 ) from the excitation spectra and I3 (the third peak at 38 5nm)/I1 (the first peak at 48 37 4nm) from the emission ... emission spectra (λex =33 9 nm) of pyrene and the I 338 /I 333 ratio from the excitation spectra (λem =39 5nm) of pyrene change with changing the polarity of the microenvir...

Ngày tải lên: 16/09/2015, 15:54

... exhibit a number of advantages over other forms of drug carriers because of their core- shell structure, low CMC and targeting ability 2. 1.4.1 Core of polymeric micelles as a reservoir for hydrophobic ... structure of the drug and polymer, temperature and pH For example, an increase in the length of a hydrophobic segment of polymer facilitates the entrapment...

Ngày tải lên: 16/09/2015, 15:54

... ability of the blank and drug- loaded core- shell nanoparticles, and structural integrity of core- shell nanoparticles during the DNA binding process, • Testing cytotoxicity of the core- shell nanoparticles ... charged shell for DNA binding By using this system, codelivery of DNA and drug can be achieved In addition, due to the unique core- shell...

Ngày tải lên: 16/09/2015, 15:54

... this article as: Fontes Garcia et al.: CdSe/TiO2 core-shell nanoparticles produced in AOT reverse micelles: applications in pollutant photodegradation using visible light Nanoscale Research Letters ... CdSe and TiO2 in the prepared nanoparticles This effect has been reported in the photoreduction of methyl viologen by CdSe and TiO nanoparticles confined in...

Ngày tải lên: 21/06/2014, 03:20

... shifts during the formation of CdSe shells were calculated, and they exhibited a good fit to the experimental data The stability of PbSe QDs was dramatically improved by the formation of CdSe shells ... photoluminescence spectra of the PbSe/CdSe QDs upon the series growth of three monolayers of CdSe shells on the 4.8 nm PbSe cores The thickness of each shell is 0.35 nm A...

Ngày tải lên: 21/06/2014, 17:20

... outstanding anti-infective properties [18] Both amphotericin B and miconazole self-assemble and solubilize at hydrophobic sites of DODAB or DHP bilayer fragments in water solution exhibiting in ... fungus viability For final coverage with polylysines (PL) of increasing molecular weight at mg/mL PL, there was an increase in the final zeta-potential modulus and a larger loss...

Ngày tải lên: 11/08/2014, 00:22

... resulting in fabrication of novel core- shell materials The objective of this work is therefore to study and perform the organic phase fabrication of core- shell materials for encapsulation of biomolecules ... for organic phase fabrication of core- shell materials; 3) Organic phase fabrication of hydrogel core- shell materials; 4)...

Ngày tải lên: 11/09/2015, 10:15

... ligand influence nanoparticle tumor localization or uptake? Trends Biotechnol 2008, 26:552 doi:10.1186/1556-276X-6-563 Cite this article as: Hou et al.: Both FA- and mPEG-conjugated chitosan nanoparticles ... mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution Nanoscale Research Letters 2011 6:563 Subm...

Ngày tải lên: 20/06/2014, 22:20

... and the Cr(VI) concentrations at any time t, respectively; V (L) is the volume of the Cr(VI) solution; and m (g) is the mass of the magnetic chitosan nanoparticles Samples of the Cr(VI) solution ... sorption experiments were performed by batch method Samples of 0.1 g of magnetic chitosan nanoparticles were equilibrated with 50 mL of solution containing vario...

Ngày tải lên: 02/07/2014, 14:14

... approximately half of febuxostat-treated patients with tophi can achieve elimination of tophi by years, and approximately 70% by years [49] Quality of life parameters have been favorably impacted by extended ... highly antigenic and has a plasma half-life of 18 to 24 hours [52] Efficacy, tolerability, and sustainability of rasburicase treatment beyond to 12 months appear to...

Ngày tải lên: 09/08/2014, 14:21

... = 0.35) Rapamycin Pharmacokinetics Measurement of rapamycin levels in vein grafts demonstrated the presence of drug in vein grafts at days (after the vein being immersed in rapamycin-loaded NPs ... release of rapamycin in the vein until day 21 after grafting which suggests that RPLGA NPs delivery system may be applied to human beings clinically The bio-absorption time o...

Ngày tải lên: 10/08/2014, 09:21

... SURFACE MODIFICATION OF FERROMAGNETIC NANOPARTICLES FOR SEPARATION OF TOXIC HEAVY METALS AND ENVIRONMENTAL APPLICATIONS ZAYED BIN ZAKIR SHAWON B.Sc (Chemical ... cost of separation of detrimental pollutants like heavy metals Recently, scientists have focused on the development of the nanomaterials as adsorbents for the separations of biomolecules,...

Ngày tải lên: 08/09/2015, 19:41

... of magnetic separation, reviews previous work on magnetic separation and introduces the recent progress in separation of chiral biomolecules, pharmaceuticals, endocrine disrupting compounds and ... SURFACE FUNCTIONALIZED MAGNETIC NANOPARTICLES FOR SEPARATION OF CHIRAL BIOMOLECULES, PHARMACEUTICALS AND ENDOCRINE DISRUPTING COMPOUNDS SUDIP...

Ngày tải lên: 09/09/2015, 17:57