Induction of anti tumor response by dendritic cell based vaccination

... presentation of TAA to cognate T cells by professional antigen-presenting cells (APC) Dendritic cells (DC) are professional antigen presenting cells (APC) with exquisite capability to activate naive T cells ... hence induction of primary immune response DC, loaded with antigen ex vivo, have been shown to induce potent anti- tumor response [1-2] The generation of clinically...

Ngày tải lên: 16/09/2015, 15:54

... the elimination of infected and tumor cells CD8 T cells start off as naïve T cells that circulate the body after development in the thymus CD8 T cells are activated by encounter with antigen, which ... Lambrecht, 2008) Stimulation of epithelial cells via PRRs results in the production of thymic stromal lymphopoietin (TSLP) that directly activates DCs to prime CD4...

Ngày tải lên: 11/09/2015, 09:11

... endothelial cells Expression of PAI-1 was analyzed at the level of protein synthesis (A) in the presence or absence of NAC (10 mM) The PAI-1 antigen was determined using the ELISA test (B) PAI-1 ... Upregulation of PAI-1 expression in endothelial cells by ROS In preliminary experiments, we evaluated the role of ROS during the stimulation of...

Ngày tải lên: 30/03/2014, 11:20

... primary colon carcinoma before start of the NK cell-based therapy, the anastomotic relapse before start of the NK cell-based therapy and the duodenom metastases after finishing the NK cell-based ... line phosphatase, γ-glutamine transferase, alanine aminotranferease (ALT), aspartate aminotransferase (AST), lactate dehydrogenase, Quick, and aPTT were determined before each le...

Ngày tải lên: 18/06/2014, 15:20

... production restricted to virus -specific cells Ethnicity and HBV genotypes influence the HBV -specific CD8+ T cell repertoire of HBV infected patients The above results show that neither race nor HBV ... Immunodominance of HBV -specific T cells Repertoire composition, quantity and qualitative functional ability are the parameters that define virus specific T...

Ngày tải lên: 10/09/2015, 08:26

... activation was Src- and Shc-dependent and resulted in enhanced expression of the uPA gene and, to a lesser extent, of the MMP-9 gene (data not shown) Disruption of cell–cell adhesion by calcium chelation ... leading to the uPA gene However, the nature of these signaling events has remained largely unknown Because both disruption of E-cadherin- depen...

Ngày tải lên: 19/02/2014, 05:20

... indication of the importance of the amino terminal fragment of NAP-22 is that the first 21 amino acids are invariant among NAP-22 of several mammalian species and this segment differs by only one residue ... membrane targeting of myristoylated and palmitoylated proteins Biochim Biophys Acta 1451, 1–16 Gratzer WB (1970) Numerical values of the absorbances of the aromat...

Ngày tải lên: 07/03/2014, 17:20

... al.: Analysis of ovarian tumor pathology by Fourier Transform Infrared Spectroscopy Journal of Ovarian Research 2010 3:27 Submit your next manuscript to BioMed Central and take full advantage of: ... from tumor cells [23] Fourier transform infrared spectroscopy has Page of been extensively employed in the field of cancer research to address the problems of...

Ngày tải lên: 20/06/2014, 07:20

... yield information on this problem The RBE value of 14.6 for cell reproductive death is similar to values in the range of to 15 published for many other lines of cultured cells [45] The RBE of derived ... in tumour cells fail to correlate with their radiosensitivity [7] On the other hand, the RBE values for induction of chromosome aberrations are q...

Ngày tải lên: 09/08/2014, 09:20

... autoantibody specificities and serum cytokine levels in guiding anti-TNF therapy Therapy responsiveness was assessed months after the start of therapy, based on the American College of Rheumatology (ACR) ... prediction in RA and in the design of a multidisciplinary biomarker set that takes in account the multifactorial nature of the response prediction The results of thi...

Ngày tải lên: 09/08/2014, 14:21

... levels of < /b> memory B cells were probably caused by a reduction of < /b> postgerminal center Bm5 (CD38+IgD-) in PB One of < /b> the explanations for this may be a normal development of < /b> immature B cells in BM and < /b> ... long-term < /b> reduction in switched memory B cells both in PB and < /b> in BM The reduction of < /b> switched memory B cells does not pr...

Ngày tải lên: 09/08/2014, 14:22

... targets of NBS1 overexpression Knockdown of HSPA4 or HSPA14 decreased in vitro migration and invasion activity To test the role of HSPA4 and HSPA14 in in vitro migration and invasion activity, siRNA-mediated ... et al.: Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1- induced in vitro metastatic and transfo...

Ngày tải lên: 10/08/2014, 05:21

... application of MDAs in chemotherapy or cancer immunotherapy Methods Chemicals and reagents 2-(3-chlorophenyl)-6,7-methylenedioxyquinolin-4-one (CMQ) and 2-(3-fluorophenyl)-6,7-methylenedioxyquinolin-4-one ... V = L × W2/2 Survival of mice was recorded over 40 days following tumor challenge Tumor cell lysis by cytotoxic T lymphocyte (CTL) Cytotoxicity assays for specific cell lysis were...

Ngày tải lên: 10/08/2014, 05:21

... Effectiveness and safety of adalimumab in patients with ankylosing spondylitis or psoriatic arthritis and history of anti-tumor necrosis factor therapy Arthritis Research & Therapy 2010, 12:R117 Page 11 of ... IFX or ETN or both: Review of Safety and Effectiveness witH Adalimumab in Patients with Active Ankylosing SpOnDYlitis (RH...

Ngày tải lên: 12/08/2014, 14:22

... region) previously shown to mediate the induction of p21 expression by tumor growth factor β (TGF-β) [41] Trans-activation of these regulatory elements by Tax and by Sp1 are additive Our data suggest ... of the bands were determined by the Scion Image software and plotted using the Prism program We thank Dr W S El-Deiry of the University of Pennsylvania, Dr K Zhao of t...

Ngày tải lên: 12/08/2014, 23:20