Molecular mechanisms underlying the pharmacological activities of naja sputatrix venom

... symptoms of envenomation and the ultimate severity of a bite depend on the size and species of the snake, the amount and degree of toxicity of the venom injected, Introduction the location of the ... MOLECULAR MECHANISMS UNDERLYING THE BIOCHEMICAL ACTIVITIES OF NAJA SPUTATRIX VENOM CHARMIAN CHER DYI NI B.Sc (Hons) A THESIS SUBMITTED FOR THE DEGR...

Ngày tải lên: 16/09/2015, 08:31

... as: Qin and Tian: Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcoholinduced fatty liver diseases in mice Journal of Translational Medicine 2010 ... mRNA expression HMW adiponectin is the major bioactive isoform of adiponectin, and is responsible for the insulin-sensitizing effects of adiponectin, whil...

Ngày tải lên: 18/06/2014, 16:20

... antithrombins are glycosylated at four of their asparagine molecules; these are of the α isoform The remaining 5–15% of circulating antithrombins, of the β isoform, lack glycosylation at asparagine ... purposes) Interaction of antithrombin with endothelium The affinity of antithrombin (AT) to thrombin and its enzymatic inhibition is increased by binding of AT with t...

Ngày tải lên: 12/08/2014, 23:21

... in the session of “Inflammatory Mechanisms in Rhinosinusal Disease”.) iv Molecular mechanisms underlying the pathogenesis of nasal polyposis and its response to steroid treatment Content of the ... through the epithelial defect and the mucosa tends to cover it by migration of the epithelium from the edges 23 of the defect; (iii) the pr...

Ngày tải lên: 10/09/2015, 15:49

... spatial and temporal resolution In this thesis, I have studied the molecular mechanisms that regulate the determination of the position of the cleavage furrow and the cleavage furrow formation in cytokinesis ... action Inhibit myosin II ATPase activity by binding to myosin II-ADP-Pi Blebbistatin and inhibit the release of the ADP Inhibit actin pol...

Ngày tải lên: 14/09/2015, 14:09

... curves of CHABII and [Phe21] -CHABII at pH 6.5 (b) Thermal unfolding curves of CHABII and [Phe21] -CHABII at pH 4.0 (c) Thermal unfolding curves of [Phe21] -CHABII at pH 4.0 and [Phe21] -CHABII at ... proteins Extensive 32 CD and NMR experiments were performed to characterize the role of His21 in the pH -induced unfolding of CHABII Thermal unfoldin...

Ngày tải lên: 26/11/2015, 12:54

... relation to learning and memory formation requirements Furthermore, the molecular mechanisms underlying the MFs redistribution during learning and memory formation are still under investigation ... hilus and CA3 area, comprise the second synapse of the hippocampal circuit In this trisynaptic model of the hippocampus, based on the observations of th...

Ngày tải lên: 09/09/2015, 18:55

... 5.2.3.1 Fear conditioning training 115 5.2.3.2 Short-term contextual memory and cued memory test 115 5.2.3.3 Retention and extinction of long-term contextual memory and cued memory ... which have been done in this thesis to investigate the underlying mechanisms of learning process and long-term memory formation In part I, two projects have been focused on...

Ngày tải lên: 09/09/2015, 18:55

... HANDLED HANDLED 40 35 30 25 20 15 10 C A2 C A2 Figure Effects of handling on MR and GR immunoreactivity in the CA2 region of the hippocampus Effects of handling on MR and GR immunoreactivity ... assay system) Statistical Analysis Data were analyzed by a one-way analysis of variance (ANOVA) with handling as the independent factor Data on learning, body weight and...

Ngày tải lên: 08/08/2014, 21:20

... lacked the last 42 amino acids Figure 2A and Table show that the ATPase activity of NBD2-DC was greater than that of SUR2B but similar to that of NBD2A, favoring the idea that the last 42 amino acids ... than those for the NBDs of SUR2A [22] SUR2A and SUR2B differ only in their last 42 amino acids, which not form part of the catalytic site Thus,...

Ngày tải lên: 06/03/2014, 11:20

... guidelines on the pharmacological treatment of persisting pain in children with medical illnesses  Contents: WHO guidelines on the pharmacological treatment of persisting pain in children with medical ... WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses WHO L...

Ngày tải lên: 07/03/2014, 04:20

... both SHP-1 promoters are transcriptionally active in hematopoietic and epithelial cells, we used RT-PCR to specifically amplify either the (I )SHP-1 or (II )SHP-1 transcripts Expression of (I )SHP-1 ... used in PCR for (I )SHP-1 with primer pair (I )SHP-1- 90-5¢ and SHP-1- 1859-3¢, or (II )SHP-1 with primer pair (II )SHP-1- 74-5¢ and SHP-1- 1859-3¢ The RT-PCR products were separated...

Ngày tải lên: 08/03/2014, 23:20

... Dependence of the hydrolysis reaction rates by neurolysisn and TOP on concentration and chemical nature of salts The dependence of the rate constants according to the concentration and the chemical ... NaCl concentration, and the extent of it was dependent on the substrate (Table 4) and on the nature of the salts (Fig 2) Therefore, the structu...

Ngày tải lên: 23/03/2014, 21:21

... representing the strongest effect on the 11bhydroxylation activity of all single mutants investigated here When both mutations were introduced into CYP11B2, the 11b-hydroxylation capacity was additionally ... strongly improve the substrate conversion in relation to the CYP11B2 wild-type protein (Fig 3) By replacing the amino acids in positions 112 and 147 of CYP1...

Ngày tải lên: 24/03/2014, 03:21

... NICE clinical guideline 96 Neuropathic pain: the pharmacological management of neuropathic pain in adults in non-specialist settings Ordering information You can download the following documents ... 96 – Neuropathic pain 24 How this guideline was developed Neuropathic pain: the pharmacological management of neuropathic pain in adults in non-...

Ngày tải lên: 31/03/2014, 13:20