Part 1 total synthesis and biological evaluation of antillatoxin and fragments part II synthetic studies towards the total synthesis of cytochalasans and tuberostemonine

... PART I TOTAL SYNTHESIS AND BIOLOGICAL EVALUATION OF ANTILLATOXIN AND FRAGMENTS PART II SYNTHETIC STUDIES TOWARDS THE TOTAL SYNTHESIS OF CYTOCHALASANS AND TUBEROSTEMONINE APPENDIX ... Biological Evaluation of Antillatoxin and Fragments 1. 1 Historical Background 1. 2 Previous Synthetic Studies 1. 3 Our Retrosynthetic Analysis of...

Ngày tải lên: 16/09/2015, 08:31

... PHOTOCHROMIC FULGIDES 17 PART I CHAPTER Synthesis of Model Fulgides CHAPTER – SYNTHESIS OF FULGIDES 2.1 PRELIMINARY SYNTHESIS OF PHOTOCHROMIC FULGIDES As a preliminary investigation of the overall synthetic ... of increasing ring size on the photochromic properties of the fulgides PART I – SYNTHESIS OF PHOTOCHROMIC FULGIDES 30 PART I CHA...

Ngày tải lên: 16/09/2015, 08:31

... PART I SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOSPHOGLYCOLIPID PGL1 ANALOGUES PART II SYNTHESIS AND BIOLOGICAL EVALUATION OF ANDROGRAPHOLIDE ANALOGUES HADHI WIJAYA (BSc (Hons.) NUS) A THESIS ... CONTENTS iv SUMMARY vii LIST OF TABLES ix LIST OF FIGURES xi LIST OF SCHEMES xv LIST OF ABBREVIATIONS xvii CHAPTER INTRODUCTION 1.1 Overview 1.2 Definiti...

Ngày tải lên: 09/09/2015, 11:26

... 1,3 ,5- Triazine Derivatives 11 1.2.2 Synthesis of 1,3 ,5- Triazine Derivatives 14 1.2.2.1 Solution phase synthesis of 2,4,6-trisubtituted -1,3 ,5- triazine 14 1.2.2.2 Solid- Phase Synthesis of 1,3 ,5- Triazine ... 65 3.4 Synthesis of 1,3 ,5- triazine Analogs via Guanidium Azolides 80 3 .5 Synthesis of 1,3 ,5- traizine-2,4-diones 3-17 81 3 .5. 1 S...

Ngày tải lên: 14/09/2015, 08:25

... Evaluation of New Anti-cancer Nitrogen-Containing Combretastatins and Novel Cysteine Protease Inhibitors for the Treatment of Chagas Rogelio Siles Mentor: Kevin G Pinney, Ph.D In an effort to combat ... Derivatives of Combretastatins A-1 and A-4 66 Synthesis of Cold Precursors of Radio-labeled Combretastatins CA-1 and CA-4 70 Synthesis of OXi800...

Ngày tải lên: 14/11/2014, 11:32

... time in second (Mean ± SEM) 0h 2h 3h 4h 1.56 ± 0.16 2. 16 ± 0.16 2. 0 ± 0 .25 2. 16 ± 0.16 2. 0 ± 0 .25 2. 0 ± 0 .25 1.61 ± 0.30 2. 16 ± 0.30 2. 0 ± 0 .25 2. 16 ± 0.16 2. 0 ± 0 .25 2. 16 ± 0.16 Control Std 3a 3b ... 14.38; found C 57 .29 , H 3.65, N 14.45 Synthesis and biological evaluation of 2- substituted benzimidazole derivatives 2. 2 .2. 2 (1H-Benoimidazol -2-...

Ngày tải lên: 02/09/2015, 13:45

... functionalized isoindigos as antiproliferative agents, the aim of this thesis was to investigate medicinal chemistry approaches towards the design and synthesis of functionalized isoindigos with ... of isoindigos without compromising biological activity 1.5 Biological properties of functionalized isoindigos 1.5.1 Mode of action of meisoindigo Meisoindigo is the most wid...

Ngày tải lên: 10/09/2015, 08:38

... SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURAL PRODUCTS AND THEIR ANALOGS AS NEW CANCER CHEMOTHERAPEUTIC AGENTS FANG ZHANXIONG (B.Sc.(Hons.) NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... production of a large number of analogs with the basic template.56 Epothilone D has shown to be at least as cytotoxic as paclitaxel against a range of...

Ngày tải lên: 10/09/2015, 15:49

... the thesis involves the design, synthesis and biological evaluation of inhibitors of Dengue and West Nile virus NS2B- NS3 protease For the design of dengue NS2B- NS3 protease inhibitors, we were inspired ... DEN2 NS2b- NS3 protease 60 Chapter 4: Synthesis and biological evaluation of small molecule inhibitors of West Nile Virus NS2B/ NS3 P...

Ngày tải lên: 14/09/2015, 08:44

... lophotoxin and 11 pukalide   x   Scheme 1. 9 Marshall’s synthesis of the furan moiety of rubifolide 11 Scheme 1. 10 Marshall’s synthesis of furan moiety from an alkynone β-ketoester 11 Scheme 1. 11 Paquette’s ... Characterisation 1. 1.2 Biological Activity 1. 1.2 .1 Antimalarial Agents and Continuing Needs 1. 1.3 Proposed Biosynthesis 1. 1.4 Related Diterpene Natural Pro...

Ngày tải lên: 11/09/2015, 09:13

Ngày tải lên: 14/11/2014, 09:37

... natural products, we have begun studies towards the total synthesis of Our approach is to mimic the biosynthesis of by the [2+ 2] photo-cycloaddition of allenyl -2( 5H)furanone 157 under high stereocontrol ... stereocontrol to form the tricyclic core27 (Figure 2. 1) Figure 2. 1: Proposed model study of the tricyclic core of bielschowskysin 2. 2 Model Study: [2+ 2] Cyclo...

Ngày tải lên: 11/09/2015, 09:13

Ngày tải lên: 11/09/2015, 09:13

... liquid, 15 Cl 14 Scheme The newly designed ionic liquid 15 Summary vii Part II: New Approach to the Formation of Bishomoallylic Alcohols – Synthesis of (R)- Sulcatol The regioselectivitives of ... Efficient Chemical Kinetic Resolution of Bishomoallylic Alcohols: Synthesis of (R )Sulcatol Publication List Table of Contents 187 216 iv Summary Part...

Ngày tải lên: 16/09/2015, 15:54

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Ngày tải lên: 09/09/2015, 10:15