Proteomic analysis of airway inflammation in murine asthma models

... protein components of the epithelial lining fluid of the airways and alveoli Distinct change in certain protein levels in BAL fluid has been correlated to allergic airway inflammation Many investigations ... staining for fibronectin 113 27 Representative 2-D gels in chronic asthma model 120 28 Protein grouping using Gene Ontology Annotation 124 29 Interactions between actin bi...

Ngày tải lên: 14/09/2015, 22:03

... eradication of inflammatory cells does not automatically lead to an improvement of clinical symptoms in airway diseases such as allergic asthma [66], other features of airway diseases such as hypersecretion ... magnification of 1000× (each group n = animals) Analysis of data The secretory basal and stimulated activity is measured as counts per minute (cpm) Data are presented a...

Ngày tải lên: 20/06/2014, 00:20

... Chronic inflammation can lead to sustained alterations of bone turnover, as typically seen in juxta-articular and periarticular damage of inflamed joints in RA TNF is a proinflammatory cytokine of ... characterized by a hyperplastic synovial membrane invading the subchondral bone (Figure 1) Compartments with different patterns of bone turnover in inflammatory arthr...

Ngày tải lên: 09/08/2014, 07:20

... Other kinases, such as casein kinase I and II, protein kinase A, 38 CDK7, DNA-activated protein kinase, and Jun-NH2 kinase (JNK), also mediate phosphorylation of p53 and play important roles in ... that in turn “protects” radiation-damaged DNA from restoring to an undamaged state Stable DNA damage accumulates and leads to an increased lethality from a given dose of radiat...

Ngày tải lên: 16/09/2015, 15:43

... airway inflammatory diseases Therapeutic targeting of LPA2 may be beneficial in reducing allergic inflammatory responses in airway diseases Competing interests The authors declare that they have ... 279(39):41085-41094 Hashimoto T, Nakano Y, Yamashita M, Fang YI, Ohata H, Momose K: Role of Rho-associated protein kinase and histamine in lysophosphatidic acid- induced...

Ngày tải lên: 12/08/2014, 14:20

... affect airway inflammation in the mouse We have previously described a murine model of asthma that includes non-specific AHR and associated eosinophilia in the airways [5] In the present study we ... Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization Am J Respir Crit Care Med 1997, 155:819-825 Hogan SP, Koskinen A...

Ngày tải lên: 12/08/2014, 18:20

... bronchial inflammation and airway hyperreactivity in mice Pharmacology 1997, 55:32-43 Satoh Y, Kasama K, Kuwabara M, Yimin, Diao HY, Nakajima H, Kohanawa M, Minagawa T: Suppression of late asthmatic ... after CpG treatment in a murine model of allergic inflammation Our results indicate that induction of Th1 response by therapy with CpG- ODN is partially depende...

Ngày tải lên: 12/08/2014, 18:21

... molecules in the course of hypoxia-induced apoptotic pathways Such analysis of trophoblastic cells will, in the near future, yield insights into the mechanisms of preeclampsia and other hypoxia-related ... and by modulating phosphorylation of JNK In conclusion, various pro- and antiapoptosis-related proteins were expressed in the process of hypoxia-induced apoptos...

Ngày tải lên: 31/10/2012, 15:12

... overexpressing a- synuclein A proteomic analysis is expected to identify cellular alterations that are associated with dopamine treatment and modulated by a- synuclein overexpression, without any a priori ... eukaryotic initiation factor 5A (eIF 5A) , parathymosin, L7 ⁄ L12, annexin A2 , annexin A5 , aldolase A, fascin and peroxyredoxin 1] displayed quantitative diff...

Ngày tải lên: 15/02/2014, 01:20

... lungs Histological findings of hematoxylin and eosin (H&E)-stained Histological findings of hematoxylin and eosin (H&E)stained lungs The groups of mice were intratracheally inoculated with vehicle, ... that a single pulmonary exposure to CSBG induces lung inflammation characterized by the infiltration of inflammatory leukocytes including eosinophils with an enhanced lung expression...

Ngày tải lên: 12/08/2014, 14:20

... reporting an ozone- induced increase in oxidative stress markers in this group of subjects [15,17] In conclusion, the increase in some markers of airway inflammation and/or oxidative stress can be observed ... al.: Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with mini...

Ngày tải lên: 12/08/2014, 14:20

... stress and release of inflammatory mediators in the airways of healthy subjects and that these effects can be both acute and chronic [1820] Compared to healthy non -smokers the degree of airway inflammation ... 3: Spearman's rank correlations between VEGF levels in induced sputum and smoking pack-years, airway obstruction, and airway inflammation in asym...

Ngày tải lên: 12/08/2014, 15:21

... horizontal line represents the median value SFC, salmeterol plus fluticasone propionate; FP/M, fluticasone propionate plus montelukast The primary outcome was the extent of airway inflammation as ... disassociated from eosinophilic airway inflammation [5-7] The residual symptoms and abnormal airway function seen in our patients in the absence of eosinophilic...

Ngày tải lên: 12/08/2014, 15:21

... may indicate the similar inflammatory response in smokers and exsmokers with COPD, which is associated not only with smoking, but also with systemic inflammation Influence of smoking may explain ... analyse airway inflammatory cell patterns in smokers and ex -smokers with COPD and to compare whether it differs from 'healthy' smokers and neversmokers Also, ac...

Ngày tải lên: 12/08/2014, 15:21

... bronchoalveolar lavage and EB as part of their clinical assessment in order to help confirm the diagnosis of asthma and to exclude any other associated abnormalities such as structural airway abnormalities ... study airway wall changes in asthma [5] Bronchial wall thickening (BWT) on HRCT has been shown to be a consistent finding in children with difficult asthma...

Ngày tải lên: 12/08/2014, 16:20