Role of abberant proteolysis in the pathogenesis of APL

... resistance can also be a result of mutations in the DNA binding domain (109) or the ligand binding domain of the RARα gene (110), reducing DNA binding or ATRA binding and its ability to regulate ... fusion protein found in 95% cases of APL (17, 18) In the remaining 5% cases of APL, fusions of RARα to other genes such as the promyelocytic leukemia zinc finger (PLZF...

Ngày tải lên: 14/09/2015, 14:11

... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... order to determine the possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients an...

Ngày tải lên: 20/06/2014, 04:20

... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... order to determine the possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients an...

Ngày tải lên: 20/06/2014, 07:20

... [23], linkage analysis of 14 candidate genes in OA kindreds resulted in the exclusion of 10 important cartilage genes, including COL2A1 [40] Analysis of 47 families with the phenotype of earlyonset ... epiphyseal dysplasias (MEDs), and the metaphyseal chondrodysplasias They are usually inherited as fully penetrant autosomal dominant disorders The expression of the O...

Ngày tải lên: 09/08/2014, 06:22

... staining for phenotypic markers in chondrocyte-like cells from human intervertebral discs Immunohistochemical staining for collagen phenotypic markers in chondrocyte-like cells from human intervertebral ... Suda A: Cathepsin G in degenerating and healthy discal tissue Clin Exp Rheumatol 1999, 17:197-204 Gruber HE, Hanley EN Jr: Analysis of aging and degeneration of the hu...

Ngày tải lên: 09/08/2014, 06:22

... have resulted in a better understanding of the role of the complement system and FcγRs, although the relative contributions and the hierarchy of these two pathways in the manifestation of disease ... both the FcR and complement system, as part of the innate immune system, are involved in early immune defense and subsequently activate and instr...

Ngày tải lên: 09/08/2014, 06:23

... other CFU-M lineage cells because it is expressed solely by cells on the bone The findings supporting a role for osteoclasts in the pathogenesis of peri-implant osteolysis have important clinical ... Research & Therapy Vol No Shen et al Figure Detection of β3 integrin in sections of human peri-implant by immunohistochemistry using a rabbit polyclonal antibody (a, b...

Ngày tải lên: 09/08/2014, 07:20

... study, performed the majority of the laboratory work and analysis, and drafted the manuscript AJF participated in the design of the study and interpretation of data JAH conceived the study, secured ... cells of the aging and degenerating intervertebral disc: immunolocalization of senescence- associated beta-galactosidase in human and sand rat discs Spine 2007,...

Ngày tải lên: 09/08/2014, 10:20

... strongly to α-actinin [12,13] Moreover, an increase in serum anti-α-actinin antibodies in lupus patients was associated with a 2.5-fold increase in the prevalence of LN [14] Finally, levels of anti-α-actinin ... followed by Manson and colleagues [1] were being treated, and anti-α-actinin antibody titers may decrease with therapy Finally, perhaps anti-dsDNA antibodie...

Ngày tải lên: 12/08/2014, 11:22

... abnormalities in systemic lupus erythematosus Curr Immunol Rev 2005, 1:61-67 Perl A: Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren’s syndrome ... regulates mammalian target of rapamycin activity and TCRζ expression in SLE The mammalian target of rapamycin (mTOR) is a serine/ threonine protein kinase a...

Ngày tải lên: 12/08/2014, 14:22

... circulating cytokine, coupled with the high specificity and high affinity of binding for the cytokine, makes the soluble receptor ideal as a cytokine antagonist Soluble recombinant human IL-4 receptor ... heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation of...

Ngày tải lên: 12/08/2014, 18:20

... lipids, resulting in changes in fluidity of the bilayer Additionally, there is increased ion permeability, inactivation of membrane enzymes and receptors, and covalent cross-linking of lipid Once ... these erythrocytes Role of white blood cells in oxidant production in acute chest syndrome Although SCD is a genetic disorder of the hemoglobin molecule, there is a...

Ngày tải lên: 12/08/2014, 18:20

Ngày tải lên: 13/08/2014, 01:20

... 1.2 The Nuclear Receptor Co- repressor (N- CoR), a component of the transcriptional repression machinery and its role in AML pathogenesis 1.2.1 The importance of the transcription machinery in the ... these factors become key initiators of AML pathogenesis 1.2.2 The Nuclear Receptor Co- Repressor (N- CoR) The nuclear receptor co- re...

Ngày tải lên: 09/09/2015, 18:55

... Marginal Zone B cells 11 1. 4 Humoral Immunity in Atherosclerosis 12 1. 4 .1 Localization of < /b> B cells in Atherosclerosis 12 1. 4.2 Association of < /b> oxLDL-specific antibodies with Atherosclerosis ... further delineates the < /b> B1 population into B1 a (CD5+) and B1 b (CD5-) sub-populations B1 cell populations, unlike B2 cells, are not maintained thro...

Ngày tải lên: 10/09/2015, 09:23