Structural studies of cysteine and serine protease inhibitors towards therapeutic applications

... mechanism of cysteine proteases 14 1.3.3 Inhibitors of Cysteine proteases 16 1.3.4 Endogenous inhibitors: Cystatin superfamily 1.3.5 Synthetic inhibitors of Cysteine proteases 1.4 Serine proteases ... mechanism of Serine proteases 23 1.4.2 Serine protease inhibitors 26 1.4.3 Serpins 27 1.4.4 Canonical serine protease inhibitors 29 1.4.5 Non canonical serine...

Ngày tải lên: 14/09/2015, 14:09

... STUDIES OF COBALT AND IRON OXIDES/ OXYHYDROXIDES NANOSTRUCTURES FOR ELECTROCHEMICAL APPLICATIONS LEE KIAN KEAT (M Sc., Universiti Teknologi Malaysia) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... and Han et al.47 1.5 Properties of cobalt compounds relevant to electrochemical applications 1.5.1 Electrochemical capacitance and electrochemistry of cobalt...

Ngày tải lên: 10/09/2015, 09:27

... structure of dNK has previously been determined in complexes with substrates and a feedback inhibitor [12,13] It has a structure similar to that of the human dGK and dCK and belongs to a structural ... specificity of dNK Earlier crystallographic studies of substrates dT and dC and on the structure of the feedback inhibitor complex with dTTP, as well as mutat...

Ngày tải lên: 16/03/2014, 06:20

... this study, we describe the structures of two homologues, TKs from B anthracis and B cereus, in complex with substrate dT and phosphate donormimicking dTTP Because of the high sequence identity ... expression and purification of human thymidine kinase 1: quaternary structure, stability, and kinetics Protein Expr Purif 47, 506–515 20 Black ME & Hruby DE (1990) Quatern...

Ngày tải lên: 23/03/2014, 09:21

... 271) strain 80204-1 produced under in vitro growth conditions on tryptic soy agar (TSA) and in vivo and have demonstrated that their structures are chemically and antigenically distinct from the ... TOF Analysis of the in vivo cultured A salmonicida strain 80204-1 cells In vivo culture was performed using ligated dialysis tubing bags filled with ba...

Ngày tải lên: 23/03/2014, 13:20

... Dissertation Topic: Biochemical and Structural Studies of Escherichia coli Leucine-responsive Regulatory Protein Experience 1997-1998 Teaching Assistant Department of Chemistry University of North Carolina, ... Biochemical and structural studies of Escherichia coli Lrp Transcriptional regulation of gene expression is an essential component for the life o...

Ngày tải lên: 14/11/2014, 06:09

... ferrocene-derivatized carbene and palladium( I) complexes have been very limited In view of the significance of copper, gold and palladium carbene complexes in organic synthesis, materials and medicine, ... enriching the knowledge of copper, gold and palladium NHC complexes, the results of this research will be instructive for mechanistic study and futu...

Ngày tải lên: 11/09/2015, 09:12

... results of Figure 1, and 4, CAAs were converted to biodegradable products at the beginning of hydrothermal reaction The production of biodegradable products by structural conversion of CAAs required ... hydrothermal reaction at 250 C and MPa Journal of Water and Environment Technology, Vol.1, No.2, 2003 acid, % of glycolic acid and % of formic a...

Ngày tải lên: 05/09/2013, 08:40

... information, the protein ligand interaction can be probed by [15N]-HSQC FEBS Journal 273 (2006) 4154 – 4159 ª 2006 The Authors Journal compilation ª 2006 FEBS 4157 15 N-labelled proteins by cell-free ... accelerated studies of proteins by NMR spectroscopy by assigning residue type information to every amide cross-peak observed in [15N]-HSQC spectra We anticipate that...

Ngày tải lên: 07/03/2014, 12:20

... 13C and 15N-NMR signals of FAD bound to wild-type TrxR and mutant proteins in the oxidized and reduced states Chemical shifts of wild-type TrxR (in p.p.m.) Dd (p.p.m.) Atom Oxidized Reduced Oxidized ... reconstituted thioredoxin reductase (TrxR), and of the native mutant protein E159Y in the oxidized and reduced states For comparison the chemical shifts...

Ngày tải lên: 16/03/2014, 16:20

... order: iron(II)HbIV > met-HbIV > met-HbI > iron(II)-HbI The larger peroxidative activity of iron(II)-HbIV with respect to metHbIV is in line with previous data obtained with human HbA derivatives [7] ... [6] Figure shows the peroxidase activity of iron(II)- and met-forms of HbI and HbIV It is evident that the enzymatic activity decreases according to the order iron(II)-HbIV > met-Hb...

Ngày tải lên: 23/03/2014, 12:20

... understanding of ThDP-dependent enzymes, as well as studies of thiamin analogues as drug molecules and in the eld of riboswitches Fig Thiamin diphosphate a-carbanion resonance structure) Depending ... in the pyridine series II Synthesis of 2-methyl-3-hydroxyethylpyridine and of the pyridine analogue of thiamine (vitamin B1) J Org Chem 6, 5462 Wooley DW (1950)...

Ngày tải lên: 29/03/2014, 23:20

... both motions of the pair The vector of the response spectra is calculated as the square root of the sum of the squares (SSRS) of the response spectra for the two different directions, and this vector ... Los Angeles Tall Buildings Structural Design Council 2006 An Alternative Procedure for Seismic Analysis and Design of Tall Buildings Located in...

Ngày tải lên: 21/07/2014, 20:20

... chronological order of FDA approval, saquinavir, ritonavir, indinavir, nelfinavir, lopinavir, atazanavir, fosamprenavir (pro-drug of amprenavir, which is no longer available), tipranavir, and darunavir ... ritonavir and one nelfinavir) The case series included more malignancies not associated with HIV or AIDS (ductal carcinoma of the breast, renal cell carcinoma, cholangiocarcinom...

Ngày tải lên: 09/08/2014, 09:20