Design of protein linkers for the controlled assembly of nanoparticles

... DESIGN OF PROTEIN LINKERS FOR THE CONTROLLED ASSEMBLY OF NANOPARTICLES CHEN HAIBIN (B ENG, XI’AN JIAOTONG UNIVERSITY, P R CHINA) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... protein forms, was investigated Chapter 1.3 Outline of the thesis This thesis is composed of eight chapters Chapter describes the motivation and defines the objecti...

Ngày tải lên: 14/09/2015, 14:08

... meet inclusion criteria of having had a medical diagnosis of Coronary Heart Disease (CHD) and being affected by major cardiovascular risk factors will be asked and screened for admission in the study ... Such appealing features have made it very attractive for some clinicians and clinical researchers who, beginning in the 90s and going on until nowadays, have sta...

Ngày tải lên: 11/08/2014, 23:23

... paper mill, there is a large steam and electricity demand at the pulp mill To simplify calculations, we decided to use only a pulp mill rather than an integrated pulp and paper mill As a result, the ... From the calculations derived in Appendix A, the energy demand for the modified pulping section of the plant is 56 MW of electricity and 267 tonnes per day...

Ngày tải lên: 26/02/2014, 14:20

... identify the structural determinants that are responsible for phosphorylation of GIRK1 by PKA, fusion proteins comprising truncated forms of the cytosolic parts of GIRK1 and the glutathione S-transferase ... GIRK1F137S) currents had been described previously [18 ] To assess the role of the S ⁄ Ts in the regulation of GIRK1 via PKA in a manner that is unbiased...

Ngày tải lên: 07/03/2014, 00:20

... equal to that of the non-depleted IMVs This indicates that YidC is required for assembly of the MscL complex (Fig 5) To investigate the role of the Sec translocon in formation of the MscL HA complex, ... of YidC had no major effect on the insertion of MscL, but formation of the pentamer was almost completely abolished under these conditions, suggest...

Ngày tải lên: 07/03/2014, 02:20

... contribute to the susceptibility of E coli model membranes to the action of AP1 An important determinant of the susceptibility of membranes to a-AMPs is the packing characteristics of the individual ... hypothesis of Tytler et al [48], it may be that insertion of the inverted wedge shape formed by the AP1 a-helix into membranes of E coli leads to the...

Ngày tải lên: 07/03/2014, 12:20

... various systems comprised 3899 and 4516 SPC molecules for the agonist and the antagonist in water, respectively, and 817 and 927 Me2SO molecules for the agonist and the antagonist, respectively, corresponding ... the binding and affinity for I-Au because of occupation of the P1 pocket Recent thermodynamic and kinetic studies of the binding of TCRs...

Ngày tải lên: 07/03/2014, 16:20

... nuclear localization for the mSMOl isoform (Fig 4) Taken together, these results consistently substantiate the hypothesis that these two structural regions are mandatory for the nuclear localization ... v) paraformaldehyde in NaCl ⁄ Pi (15 at °C) to evaluate the subcellular localization of the various isoforms Determination of the subcellular localization...

Ngày tải lên: 07/03/2014, 17:20

... 5¢-CCC CGG GCC CGA ATT CCT TTC TTT CTT TCT TTC TTT CTT TCT TTC TTT CTT TCT TTC TTT TTT TTT TTC TCG AGC CCC-3¢; antisense: 5¢-GGG GCT CGA GAA AAA AAA AAA GAA AGA AAG AAA GAA AGA AAG AAA GAA AGA AAG ... luciferase -MARCKS construct and for transient transfection with the cDNAs coding for human HuD and HuR The mouse embryonic carcinoma cell line PCC7-Mz1 is a subclone of...

Ngày tải lên: 08/03/2014, 08:20

... 1982) The elements of the vocabulary of a control language are names of PSs, and the well-formed strings of the language define just those sequences of PS applications which are allowed The user ... It follows that the generator must provide compilations of these defintions in the language of the kernel machine The implementation of the control generator...

Ngày tải lên: 08/03/2014, 18:20

... similarity with MPs of viruses from other genera Within sobemoviruses, the sequence of the SeMV MP was closest to that of the SBMV-Ark MP (32% sequence identity), and the identity with MPs of other ... Alfalfa mosaic virus Cucumber mosaic virus Cowpea mosaic virus Brome mosaic virus Tobamovirus Alfamovirus Cucumovirus Comovirus Bromovirus Percentage ident...

Ngày tải lên: 15/03/2014, 00:20

... show differential tissue-specific distribution of fabp10a and fabp10b transcripts in developing and adult zebrafish, evidence of the divergence of regulatory elements in the promoters of the fabp10a ... vesicles indicates a potential role for this protein in the early development of the zebrafish brain Tissue-specific distribution of fabp10b ge...

Ngày tải lên: 16/03/2014, 00:20

... EÆMgATP complex is not a deadend complex with respect to the binding and phos4633 Kinetic mechanism for p38 MAP kinase a A E Szafranska and K N Dalby Fig Preparation of activated p38 MAPKa and ATF2D115 ... propose, therefore, that the kinetic mechanism for p38 MAPKa should be reassigned as a partial rapidequilibrium random-order ternary-complex mechani...

Ngày tải lên: 16/03/2014, 22:20

... Glu39 in 40 out Ó FEBS 2002 of 40 DYANA models) further support the continuous C-terminal helix structure Monitoring the Phe12 fi D-Phe and Leu15 fi Aib substitution The NOE pattern of the CRH analogue ... Arg16 and Glu20 The biological impact of the Aib1 5 and D -Phe12 modifications on the synthetic CRH analogue is illustrated by the pepti...

Ngày tải lên: 17/03/2014, 10:20