Role of multidrug resistance associated protein 4 (MRP4 ABCC4) in the resistance and toxicity of oxazaphosphorines

... resistance profiles of MRP4/ABCC4 to oxazaphosphorines including CP and IF in the absence and presence of various MRP4/ABCC4 inhibitors or MRP4/ABCC4 inducers by using the MRP4/ABCC4 overexpressing HepG2 ... interesting to investigate the effect of the combination of oxazaphosphorines and -x- MRP4/ABCC4 inhibitors on cancer treatment, and to investigate the e...

Ngày tải lên: 14/09/2015, 14:06

... EFFECTS OF PLANT POLYPHENOLS AND MUTATIONAL ANALYSIS OF MULTIDRUG RESISTANCE PROTEIN (MRP4/ ABCC4) FUNCTIONS WU JUAN (B.M., Peking University) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ... by MRP4/Hep G2 cells 84 4.1 .4 Effects of plant polyphenols on GSH efflux mediated by MRP4 87 4. 2 Cloning and expression of mutant MRP4 93 4. 2.1 PCR...

Ngày tải lên: 05/10/2015, 13:53

... suggesting that CIDEC might be a target of PPARc transactivation These data suggest that CIDEC may not only be a downstream target of PPARc transactivation, but is also likely to be involved in a ... human adipocyte differentiation F Li et al mRNA in 3T3-L1 adipocytes, whereas the expression of a dominant-negative mutant of PPARc results in a decrease...

Ngày tải lên: 23/03/2014, 03:20

... The chaotrope-induced unfolding was almost fully reversible in both forms of the protein Removal of the perturbation makes the protein regain its native form The unfolding reactions of both forms ... as the major and the minor forms of the holoACP structure, on the basis of their percentage contributions (65% and 35%, respectively) to the...

Ngày tải lên: 16/03/2014, 10:20

... pumping of the agents out of the cells and their passive uptake [10,31] and (b) competition between the active pumping of the agents out of the cells and their intracellular binding to receptors and ... allowing the enhanced uptake of rhodamine dyes inhibited the efflux of these dyes from the cells The efflux of rhodamine 123 and TMRM was inhibited by NBD...

Ngày tải lên: 18/02/2014, 13:20

... Figure 39 WT rgs1D Figure 40 Figure 41 Figure 42 _ Figure 43 - Gd + Gd, 1h + Gd, 0h + Gd, 2h + Gd, 0.5h + Gd, 3h _ Figure 44 A WT rgs1D Solvent Solvent 10mM 8-Br-cAMP 10mM 8-Br-cAMP _ B WT rgs1D ... Solvent 10mM 8-Br-cAMP 10mM 8-Br-cAMP _ B WT rgs1D Figure 45 Appressorium formation on inductive membrane (%) Appressorium formation on Noninductive membrane (%) WT 89 1.5 mscL∆ 92 mscS1∆ 87...

Ngày tải lên: 14/09/2015, 09:53

... Atlanta, GA 30333 SUGGESTED CITATION Centers for Disease Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by ... Committee and the Advisory Committee for Elimination of Tuberculosis published a joint statement on the use of BCG va...

Ngày tải lên: 15/02/2014, 13:20

... bear structural similarity to the tight loop formed by L73–V78 of VpUcyt in the presence of DPC micelles Although the structural motifs adopted by the cytoplasmic domain of VpU appear to be qualitatively ... structure of the cytoplasmic domain of the human immunodeficiency virus type encoded virus protein U (Vpu) Int J Pept Protein Res 47, 297–...

Ngày tải lên: 18/02/2014, 06:20

... that the hypodermis of the body wall, which synthesizes components of the cuticle, may offer a useful target for studies into the mechanism of the development and molting process in the roundworms ... presence of increasing concentrations of inhibitors for 10 days, and the number of molting larvae was determined Molting was manifested by shedding of...

Ngày tải lên: 20/02/2014, 11:20

... Spatio-temporal distribution of cellular retinol-binding protein gene transcripts (CRBPI and CRBPII) in the developing and adult zebrafish (Danio rerio) Eur J Biochem 271, 339–348 Ohmachi T, Inoue ... Alves-Costa et al The zebrafish fabp6 gene Distribution of fabp6 gene transcripts in zebrafish embryos and larvae Fig A neighbor-joining tree sho...

Ngày tải lên: 07/03/2014, 06:20

... mussel M galloprovincialis Results Separation of different isoforms of the C -subunit In order to demonstrate the presence of different isoforms of the PKA C -subunit in mussels, the protein was ... isoforms [33] In summary, in this work we demonstrate the presence of several structurally different isoforms of the PKA C -subunit in mussel tissu...

Ngày tải lên: 07/03/2014, 06:20

... in Role of helix and C-termini in bradykinin receptors receptor signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine ... TSIfiAAA N3 38* B1wt B1RB2 B1NB2 B1CB2 B1KB2 B1KB2 ⁄ SfiV B1KB2 ⁄ QGVfiKQ B1KB2 ⁄ VCfiCV B1YB2 B1V323S 10400 5020 52 98 383 2 625 127 511 1701 182 3 17 58 2142 1 786...

Ngày tải lên: 07/03/2014, 16:20

... show differential tissue-specific distribution of fabp10a and fabp10b transcripts in developing and adult zebrafish, evidence of the divergence of regulatory elements in the promoters of the fabp10a ... vesicles indicates a potential role for this protein in the early development of the zebrafish brain Tissue-specific distribution of fabp10b ge...

Ngày tải lên: 16/03/2014, 00:20

... postinfection, we observed a marked difference between the number of CFUs of the wild-type strain and that of the PMM56 mutant strain in lungs and in the spleen (Fig 7A) Indeed, both strains ... cell envelope of M tuberculosis and to virulence [3–6] Nevertheless, their precise molecular mechanisms of action are still unknown, and the specific roles of...

Ngày tải lên: 23/03/2014, 09:20