... likely mediated by activation of the MAPK pathway and that this response is substantially independent of the JAK/STAT pathway DISCUSSION Fig STAT3 and MAPK activation by Hyper-CNTF in PC12 cells ... was obtained from Amersham International (Aylesbury, UK) X-ray films (X-OMAT-AR) were from Eastman Kodak (Rochester, NJ) Cells, cytokines and antibodies PC12 and COS-7 cells (ATCC, Manassas, VA, ... out to be virtually as effective as NGF and Hyper-IL-6 to elicit neuronal differentiation STAT3 and MAPK activation by Hyper-CNTF in PC12 cells We then asked which signal transduction pathways are...