Hydrogen sulfide, a cardioprotective agent in ischemic heart
Hydrogen sulfide, a cardioprotective agent in ischemic heart
... the accumulation of metabolites and inorganic phosphate With a substantial decline in ATP, the Na+, K+-ATPase is inhibited, resulting in a further decline of K+ and an increase in Na+ Intracellular ... stress, and cell adherence They function in a three-tier module comprising of a MAPK kinase kinase, a MAPK kinase and a MAPK The mammalian MAPK can be subdivided into five families: 42 and 44-kDa extracellular ... cardiac myocytes Journal of Pharmacology Experimental Therapeutics, 2006; 316(2):670-8 ii ABBREVIATIONS AAR area at risk BCA β-cyano-L-alanine CABG coronary artery bypass grafting CBS cystathionine...
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Hydrogen sulfide and neurogenic inflammation in a murine model of polymicrobial sepsis
... established as a novel mediator of inflammation It has been demonstrated to play a pro-inflammatory role in animal models of local and systemic inflammation, including carrageenan-induced hindpaw ... 3-mercaptopyruvate sulfurtransferase AC adenylyl cyclase AECOPD Acute exarcebation of chronic obsructive pulmonary disease ALI Acute lung injury ALT Alanine aminotransferase ANOVA Analysis of variance ... systemic inflammation and multiple organ damage caused by CLP-induced sepsis under the pro-inflammatory impact of H2S Capsazepine also delayed the onset of lethality and protected against sepsis- associated...
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báo cáo hóa học: " Japanese experience of hydrogen sulfide: the suicide craze in 2008" pptx
... associated with accidents in the sewer and mining industry The gas is not only soluble in water, but also in petroleum H2S inhibits enzymes in mitochondria by binding with Fe3+ of cytochrome oxidase ... を中心に】神経中毒 硫化水素中毒 Clinical Neuroscience 2009, 27(8):894-896 doi:10.1186/1745-6673-5-28 Cite this article as: Morii et al.: Japanese experience of hydrogen sulfide: the suicide craze in 2008 Journal of Occupational ... conditions (Table 2) The efficacy and administration method of this drug have been discussed in some Japanese language articles Here is a brief review of those findings[3] The level of Met-Hb should...
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Báo cáo y học: "Impact of obstructive sleep apnea on the occurrence of restenosis after elective percutaneous coronary intervention in ischemic heart disease" ppt
... Coronary angiography, percutaneuous coronary intervention, quantification of Restenosis Selective coronary angiography was performed following the administration of intracoronary glyceryl nitrate At ... circumflex coronary artery; RCA: Right coronary artery; PCI: Percutaneous coronary intervention; PTCA: Percutaneous transluminal coronary angioplasty; AHI: Apnea hypopnea index; CPAP: Continuous ... patients with OSA In this regard, there is only one study investigating the contribution of nocturnal hypoxemia to the development of restenosis after percutaneous coronary intervention Hayashi et al...
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Transplantation of skeletal myoblast in ischemic heart disease 1
... Figure 3.2 Figure 3.3 11 2 11 3 11 4 11 5 11 6 11 7 11 8 11 9 12 0 12 2 12 3 12 4 12 5 12 6 12 7 12 8 12 9 13 0 13 1 13 3 13 5 13 7 13 8 13 9 14 1 14 2 14 3 14 4 14 5 vii and β-gal assay 14 6 Figure 3. 31 Linear relationship ... Mechanism of myoblast transplantation Limitation of the present study Future directions Conclusion Bibliography 15 1 15 1 15 3 15 6 15 7 15 9 16 0 16 3 16 4 16 6 16 7 16 9 17 1 17 2 17 5 17 8 17 9 18 2 xv ... expression 2 .11 .1 Immunostaining for MHC 2 .11 .2 MHC expression by RT-PCR 2 .11 .2 .1 RNA preparation 2 .11 .2.2 RT-PCR Histological and immunohistological study 2 .12 .1 Staining for skeletal muscle actin, and...
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Transplantation of skeletal myoblast in ischemic heart disease 2
... less useful for treating chronic myocardial ischemia 1 .2. 2.3 .2 Intracoronary Artery Infusion Intracoronary injection allows homogeneous homing of cells into areas bordering the infarction zone It ... Suzuki et al 20 01 Species Sheep Rat Suzuki et al 20 01 Rat Jain et al 20 01 Rat Gulbins et al 20 02 Dib et al 20 02 Ghostine et al 20 02 30 days Rat Ligation Autologous SkMs Zhong et al 20 03 Dog Ligation ... NYHA improved, EF increased from 24 .3% to 32. 2% at 12 months None EF from 21 % to 29 % (2 years) EF from 28 % to 35%(1 year) to 36% (2 years) 10 21 7 x 106 67% Desmin+ Steendijk et al 20 06 CABG, allograft...
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Glial cell line drived neurotrophic factor (GDNF) family of ligands is a mitogenic agent in human glioblastoma and confers chemoresistance in a ligand specific fashion
... and Akt in both LN-229 and A1 72 human glioblastoma cell lines GDNF was however found to reduce the background activation of JNK and the A1 72 human glioblastoma cell line in a timedependent fashion ... potentiate adjuvant therapy It is likely that the chemoresistance properties are potentiated by autocrine and paracrine pathways and facilitated by mitogenic agents Local tissue invasion distinguishes ... treatment311 In the light of the evidence, we examined the modulation of MAPK and Akt signaling pathways in glioblastoma cell lines LN-229 and A1 72 human glioblastoma cell 12 lines were stimulated...
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Hydrogen sulfide produces cardioprotective effects against ischemia reperfusion injury via regulation of intracelluar PH
... value in the group of myocytes subjected to ischemia/ reperfusion injury 30 3.2 NaHS induced cardioprotection via regulation of intracellular pH 3.2.1 Effect of NaHS on pHi in the rat ventricular ... the cell viability of cardiac myocytes subjected to ischemia (30 min) /reperfusion (10 min) C, group data show the protective effects of NaHS against the cardiac myocytes injury induced by ischemia ... signaling mechanisms of H2S Moreover, researchers have recently found that pre- and post-conditioning with H2S produced cardioprotective effects against ischemic injury via regulation of protein kinase...
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The role of hydrogen sulfide in normal and ischemic heart
... Summary Ischemic heart disease is the leading cause of death in the western society and a major health problem in developing countries In the current study, the role of hydrogen sulfide (H2S) in the ... blood flow into and out of the heart A region of the heart called the sinoatrial (SA) node is capable of producing and discharging an action potential and sending the impulse across the atria ... the abnormality in H2S level is a cause or simply a consequence of these diseases There is also growing interest in understanding the role of H2S in pain appreciation Administration of either...
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Báo cáo y học: " Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects" ppt
... article as: Derwall et al.: Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic ... [31] Inhibitory effects of H2S in the presence of increased metabolism in larger mammals warrants further study Page of 10 Our results show that administration of H2S via a cardiopulmonary bypass ... Boston, MA, USA, and adhered to the principles of the Declaration of Helsinki and the Recommendations for the Care and Use of Animals Animal housing and maintenance Five female purebred Polypay sheep...
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A novel role of hydrogen sulfide in wound healing and a new approach to wound dressing in rat model
... inflammation and wound recovery after PAG administration (3) Compare the H2S releasing profiles and outcomes of S-diclofenac administration and PAG incorporated hydrogel dressing on wound healing ... microplate reader (Tecan Systems Inc.) All standards and samples were assayed in duplicate The H2S concentration of each sample was calculated according to a standard curve of NaHS (3.125−250 µM) and ... of inflammation) increased in wounded skin, and PAG administration significantly reduced MPO activity in wounded skin compared to non-treated animals Histological analysis also revealed that aggregated...
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Therapeutic effect of hydrogen sulfide in a parkinsons disease model
... NSW, Australia) Data was analyzed using PowerChrom (eDAQ, Australia) 2.15 Statistical analysis Statistical significance was assessed with one-way analysis of variance (ANOVA) followed by a post ... potential application of ADT as an H2S-releasing agent for disease treatments It was speculated that the combination of L-Dopa and H2S may have potential therapeutic value [233, 234] ACS84, which ... [155-157] As discussed above, Parkin and PINK1 are involved in the mitochondria maintenance, and mutations on Parkin and PINK1 would lead to familial PD The knockouts of parkin or pink1 in Drosophila...
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Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
... precision of therapy like the intensity-modulated radiation therapy (IMRT) and the use of heavy ions demands absolute reliability of new diagnostics and treatment planning for prostate and brain ... 14 It was used to investigate whether an intracellular MR imaging is possible and to estimate the T1 relaxivity on MR (1.5 T) Historically already in 1994 electron-spin-resonance and mass-spectrometry ... Okumura M, Mikawa M, Yokawa T, et al Evaluation of water-soluble metallofullerenes as MRI contrast agents Acad Radiol 2002; (Suppl 2): S495-S497 Tang J, Xing G, Zhao F, et al Modulation of structural...
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