Modulation of drug transport pathways by spices

... governed by the concentration gradient of the permeant across the luminal and basal membranes The rate of transport is often directly proportional to the gradient Transport of solute by passive ... project was that spices consumed as food supplements could affect oral drug bioavailability by interfering with intestinal drug transport To prove our hypothesis, a series...

Ngày tải lên: 14/09/2015, 12:37

... MODULATION OF DRUG TRANSPORT BY CITRUS FRUIT JUICES LIM SIOK LAM (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF PHARMACY NATIONAL UNIVERSITY OF ... 1.2.2.3 Lime and lemon juices 37 1.2.2.4 Other citrus fruit juices 37 1.3 Statement of purpose 38 Chapter Effects of citrus fruit juices on cytotoxicity and dr...

Ngày tải lên: 14/09/2015, 18:34

... (C), in the presence of 100 lM MPP+ (D), in the presence of 200 lM MPP+ (E), in the presence of 100 lM MPTP and 50 lM dopamine (F), in the presence of 200 lM MPTP and 50 lM dopamine (G), in the presence ... shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 lm dopamin...

Ngày tải lên: 14/02/2014, 19:20

... 116 ⁄ 1992 of the Italian Ministry of Health Focal cerebral ischemia Brain ischemia was induced by MCAo in male Wistar rats (280–320 g) by intraluminal filament, using the relatively noninvasive ... known to protect the brain against focal ischemia [35] In order to investigate the role of the endocannabinoid system in the neuroprotection afforde...

Ngày tải lên: 23/03/2014, 07:20

... < 0.05 (b) Inhibition of leukocyte adherence to the postcapillary endothelium by ALP in vivo The results show the number of leukocytes adherent to the endothelium of postcapillary synovial venules ... subsequent off-line analysis ALP in vivo Inhibition of leukocyte interaction with the postcapillary endothelium by ALP in vivo (a) Inhibition of leukocyt...

Ngày tải lên: 09/08/2014, 08:22

... materials The overarching aim is to promote the safe re-use of drug preparation and injection equipment, and to impact the large number of IDUs in San Juan who maintain personal injection syringes ... transfer of drug solution to injection syringe(s) Cleaning injection syringe IDUs in San Juan normally rinse a re-used injection syringe by drawin...

Ngày tải lên: 11/08/2014, 18:20

... modest activation of lysine hydroxylase and hydroxylysine glycosyltransferase, allowing partial glycosylation of the product This system closely mimics the post-translational system of mammalian cells ... is only partially duplicated by other Th 2type cytokines in the absence of IL-4 [16] Taken together these data suggest that the adenoX-rCB11-A9 therapy may work by inducing a po...

Ngày tải lên: 12/08/2014, 14:22

... the anesthetics benzyl alcohol, propofol, chloroform and diethyl ether reversed the resistance by acceleration of the passive transport of the drug or dye across the plasma membrane At these concentrations, ... concentrations, the anesthetics further enhanced the rate of passive drug permeation and interfered with the active export of the drug...

Ngày tải lên: 30/03/2014, 04:20

... 6847 was added, and ATP inux was recorded; after 150 s, alamethicin was added, and ATP hydrolysis by the F0F1-ATP synthase was recorded) Fmin and Fmax were subsequently recorded as detailed above ... before and after the addition of ADP (2 mm) to WT and CYPD KO mitochondria, and calculated on the basis of steady-state titration data by catr and olgm The activities of ANT and F0...

Ngày tải lên: 14/02/2014, 19:20

... Sterol homeostasis modulation by Ste20p and Cla4p M Lin et al Introduction The Rho-type GTPase Cdc42p plays a crucial role in the establishment and maintenance of cell polarity [1,2] In the ... that sterol 7254 biosynthesis may increase during formation of a mating projection [28] Furthermore, homologues of oxysterolbinding proteins, a family of proteins...

Ngày tải lên: 18/02/2014, 13:20

... arrangement by the influence of amino acids C266 and L268 These residues face the other side of this tyrosine and are members of a conserved loop (266CGLKG270) that shapes part of the FNR catalytic site ... interaction between the flavin, Y308 and the nicotinamide of NADP+ is precisely tuned by selecting amino acids that face the other side of the tyrosine...

Ngày tải lên: 18/02/2014, 17:20

... cyclin D1 gene promoter We studied the mechanism(s) underlying the inhibition of cyclin D1 gene expression by EPA and DHA by examining the effects of n-3 and n-6 PUFAs incorporation on cyclin D1 promoter ... control of SMC proliferation 4466 S Bousserouel et al (Eur J Biochem 271) Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb...

Ngày tải lên: 19/02/2014, 16:20

... suggest that the dual modulation of prothrombin activation by plactin leads to an antithrombotic state under physiological coagulating conditions Dual modulation of prothrombin activation 1st ... the N-terminus of its B-chain [19] The sequential mechanism leading to enhancement of scu-PA activation is shown in Fig 3F Dual modulation of prothrombin...

Ngày tải lên: 07/03/2014, 00:20

... tighter binding of cadmium than zinc in metallothioneins and the preference of zinc in the more flexible b-domain In addition to the already described differences in flexibility of the b-domain in MT ... reported increased metal release in the presence of oxidized glutathione (GSSG) and even slightly tighter metal binding under the in uence of reduced...

Ngày tải lên: 07/03/2014, 15:20

... In these authors’ opinions, such studies obviously represent the next logical step in the unfolding story of the modulation of the oligomeric structures of HIV-1 viral enzymes by synthetic peptides ... 75% of the total Gibbs energy [15] The importance of this four-stranded b sheet is further emphasized by the fact that all PR dimerization inhibitors d...

Ngày tải lên: 08/03/2014, 09:20