Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice

... region of < /b> SHIP-1 binds to Dok-< /b> 3 < /b> at domain B and D; the < /b> SH2 domain of < /b> Grb2 binds to 39< /b> Dok-< /b> 3 < /b> at domain D; while the < /b> region responsible for binding of < /b> Abl to Dok-< /b> 3 < /b> at B is still unknown 1.4.5 .3 < /b> Dok-< /b> 4, ... SC -37< /b> 1 SC- 728 SC- 738< /b> 3 39< /b> 41 Goat Goat Rabbit Rabbit Rabbit Rabbit R...

Ngày tải lên: 14/09/2015, 09:08

... An inhibitory adaptor regulating B cell receptor signaling 3.< /b> 1 Introduction 75 3.< /b> 2 Generation of < /b> Dok-< /b> 3 < /b> deficient mice 76 3.< /b> 3 Studying the < /b> role < /b> of < /b> Dok-< /b> 3 < /b> in < /b> B cell development 81 3.< /b> 3.1 Dok-< /b> 3 < /b> is ... FcγRIIB signaling 3.< /b> 7.2 Role < /b> of < /b> Dok-< /b> 3 < /b> in <...

Ngày tải lên: 14/09/2015, 10:44

... 28 2. 1 Fish Spawning and Maintenance 28 2. 2 Molecular Biology Techniques 28 2. 2.1 RT-PCR Molecular Cloning 28 2. 2 .2 Polymerase Chain Reaction (PCR) 29 2. 2.3 Agarose Gel Electrophoresis 29 2. 2.4 ... prior finding of possibly interacting proteins of BNIP- 2 led to the formation of research questions: Does the physical interaction of BNIP- 2 with these prote...

Ngày tải lên: 05/10/2015, 19:05

... III- 3. 8 Dok3 interacts with TRAF3 and TBK1 and is required for TBK1 binding to TRAF3 in TLR3 signalling III-80 3. 9 Dok3 binds TRAF3 and TBK1 via SH2 target motif III- 83 3.10 Dok3 does ... Dok3 binding, ABIN1 (A20-binding inhibitor of NFB) in RAW 264.7 cells upon stimulation with LPS The interaction of Dok3 and ABIN1 was then confirmed by immunoprecipitating Dok3 and immuno...

Ngày tải lên: 09/09/2015, 10:16

... counteracts the calcineurin induced affinity switch of a5b1 integrin in CHO cells, suggesting also a role for Ca2+/calmodulin- dependent molecules in regulating the affinity state of integrins on neutrophils ... Ca2+/calmodulin- dependent kinases in human neutrophils Increased [Ca2+]i is sufficient to regulate multiple intracellular signaling pathways Therefore, the ro...

Ngày tải lên: 08/03/2014, 10:20

... to the solvent, thus allowing for the binding of larger substituents (Fig 2A) The CH atoms of the substrate ring at positions and point towards the backbone of Leu248 and the side chain of Thr249, ... shown) The contacts between the edge of the dihydroxylated substrate ring and the active site pocket are probably involved in the determination of...

Ngày tải lên: 30/03/2014, 10:20

... unwavering support of my goals iv ABSTRACT Sara M McNeil ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU8 0 CTERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU DNA double strand breaks ... than that of the 16 kDa Ku8 0CTR band and the band intensity generated from Ku7 0 and Ku8 0 C antibodies, indicating a small per...

Ngày tải lên: 24/08/2014, 11:02

... polyproline sequences and interacts with profilin (Chang et al 1997) Since profilin binds to actin monomer, FH1 domains can bind the profilin-G-actin 13 Arp2/ 3 complex in border cell migration ... actin assembly In Drosophila, the Arp2/ 3 complex functions in actin dynamics together with SCAR/WAVE and WASP proteins The Drosophila Arp2/ 3 complex and SCAR/...

Ngày tải lên: 10/09/2015, 15:48

... transgenic line Establishing the role of autophagy in liver cancer 4.1 Preliminary data implicating autophagy inhibition in liver cancer 4.2 Establishing double transgenic lines with liver- specific ... as a model organism in the study of human diseases including cancers, we aim to investigate the role of autophagy in liver cancer using our establish...

Ngày tải lên: 12/10/2015, 17:35

... in raising the profile of women in management or leadership roles Early leadership theories In the 18th and 19th centuries, philosophers suggested a theory of leadership which was termed the ... although the leadership literature has played a significant role in raising the profile of women in management, further advances are required in...

Ngày tải lên: 08/10/2013, 15:56

... globalization II Review of Institution Building in the Financial Sector A Main driving forces of institution building A review of the developments of China s financial sector over the past 20 years reveals ... unique role in institution building in the financial sector They help to mitigate financial repression in China, to establish sound...

Ngày tải lên: 18/10/2013, 07:15

... Atlanta, GA 30333 SUGGESTED CITATION Centers for Disease Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by ... Committee and the Advisory Committee for Elimination of Tuberculosis published a joint statement on the use of BCG va...

Ngày tải lên: 15/02/2014, 13:20

... Reserve therefore has a strong interest in understanding issues facing community banks I THE CURRENT ROLE OF COMMUNITY BANKS The banking system in the United States has always been unique in the ... While community banks still comprise the vast majority of banks, the question arises whether their role in the banking system has declined to the point...

Ngày tải lên: 16/02/2014, 11:20

... geometry of the hinge loop after ligation Also in this case no clashes were detected at Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the ... the C-terminal and N-terminal structural regions, respectively, of the two A and B monomers of the dimeric RNase The black circle between the monom...

Ngày tải lên: 19/02/2014, 06:20

... side-chains are important for the GABA transport activity 1- Deoxymannojirimycin inhibits the GABA- uptake of GAT1 In order to gain further insight into the role of the terminal structures of the N-glycans ... N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT...

Ngày tải lên: 19/02/2014, 17:20