PINI and MEK2 regulate BPGAPI induced ERK activation and cell migration

... enhanced cell motility induced by BPGAP1 and Mek2- SD 129 Figure 4.1 A schematic model of Mek2 acting as a scaffold to promote the binding between Pin1 and BPGAP1 and suppresses BPGAP1 -induced acute Erk ... diverse cellular responses: cell growth and differentiation, gene expression, mitosis, cell motility, metabolism, cell survival and apoptosis, and embryogenesi...

Ngày tải lên: 14/09/2015, 08:47

... 17b-Estradiol Inhibits PGE2-Induced Cell Migration in Human LoVo Colon Cancer Cells In the present study, we examined the effects of PGE2 on the migration ability in human LoVo colon cancer cells ... against PGE2-induced progression in colon cancer remains unclear In the present study, we examined the effects of 17b-estradiol on PGE2-induced cellular...

Ngày tải lên: 10/08/2014, 10:20

... CSF-1-induced ERK activation by cAMP is perhaps surprising given the suppression of tyrosine phosphorylation noted 4145 cAMP modulates CSF-1R signalling N J Wilson et al A B C D E F Fig cAMP inhibits ... CSF-1R-dependent tyrosine phosphorylation Results cAMP augments CSF-1-induced differentiation of M1/WT cells We have previously established a model of CSF-1induced...

Ngày tải lên: 16/03/2014, 22:20

... neuronal death FEBS J Teixeiro E & Daniels MA (2009) ERK and cell death: ERK location and T cell selection FEBS J Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation ... ERK- mediated cell death: sustained and sequestered activity ROS as mediators of ERK- induced cell death In the majority of the studies rela...

Ngày tải lên: 29/03/2014, 08:20

... considered and the conditions of cadmium exposure [31,32] 42 Cadmium entry into cells is required for sustained ERK activation and subsequent cell death Cadmium has long been shown to accumulate in cells ... the sustained activation of ERK following cadmium poisoning [33,38] In conclusion, these data strongly suggest that ROS production following cadmium poisonin...

Ngày tải lên: 29/03/2014, 08:20

... of AR in the HAT-induced biphasic ERK activation was investigated using an antiAR neutralizing antibody The HAT-induced initial ERK activation (5 after stimulation with HAT) was inhibited by a ... epithelium increases in bronchial asthmatic patients [10] These observations suggest that HAT might mediate airway in ammation by PAR-2 activation In addition to airway in am...

Ngày tải lên: 30/03/2014, 11:20

... not inhibit the activation of PAK1 by LPA in A2058 cells PAK1 activation is required for LPA-induced FAK phosphorylation and motility LPA has been shown to increase phosphorylation of FAK in human ... cells, cells were pretreated with either tyrosine kinase inhibitor, genistein, or MAP kinase inhibitor, PD98059 Inhibition of tyrosine kinase by genist...

Ngày tải lên: 30/03/2014, 13:20

... predominant cell types involved in pulmonary fibrosis are fibroblasts and myofibroblasts, and the damaged epithelium can activate transformation of fibroblasts to myofibroblasts or Page of 14 (page ... infiltration and apoptosis depend on apoptosis signal-regulated kinase < /b> pathway Crit Care Med 2005, 33:1913-1921 Yaekashiwa M, Nakayama S, Ohnuma K, Sakai T, Abe T, Satoh K, M...

Ngày tải lên: 13/08/2014, 11:22

... chemokines in organs distal to the lung, such as liver and kidney • Ventilator-induced endothelial activation and inflammation in both the lung and distal organs may be crucial factors in the pathogenesis ... possibly via α-adrenergic activation [40,42,43] Therefore, the systemic endothelial activation and inflammation caused by ventilator-induced...

Ngày tải lên: 13/08/2014, 19:20

... mPTP-opening induced by rBAX To gain insight into the existence of putative mitochondrial lipid microdomains in vivo, we evaluated the inducing effect of rBAX on opening of the mPTP in kidney ... glycosphingolipid fractions, obtained from the same amount of mitochondrial protein, were loaded and developed with sulfuric acid (unspecific) and resorcinol (ganglioside -specific stain) By i...

Ngày tải lên: 07/03/2014, 05:20

... that Cas utilizes Nck2 to regulate cell polarization and Cdc42 activity during cell migration in response to wound healing Results Cas is required for the polarization of migrating cells To examine ... durhealing [1] The effects of Cas on Cdc42 during wound healing were evaluated by 3503 Cas ⁄ Nck2 regulates cell polarity A CasKo CasWt K...

Ngày tải lên: 23/03/2014, 03:20

... that sustained 24 Fig Model of ERK1 ⁄ in life and death Both survival and death signals can activate ERK1 ⁄ The mechanisms involved in such differential ERK1 ⁄ activation and how ERK1 ⁄ interacts ... often linked to an activation of the ERK1 ⁄ pathway ROS-induced ERK1 ⁄ activation has been demonstrated in a wide variety of cells, including neurons [22] Oxidants induce n...

Ngày tải lên: 29/03/2014, 08:20

... and lead to Ras-GRP1 recruitment to that location Recent work has demonstrated that in T cells, PLCc1 activation leads to activation of Ras-GRP1 and its recruitment to the Golgi and lymphocyte ... attractive to hypothesize that the differential compartmentalization of Ras ⁄ ERK pathways provides the thymocyte with the ability to distinguish between positive and negative selectin...

Ngày tải lên: 29/03/2014, 08:20

... its PKA activity Finally we tested the effect of H-89, a known inhibitor of PKA, on the expression of both the proglucagon gene promoter and the Cdx-2 gene promoter in the PKA active GLUTag cell ... al Activation of Cdx-2 expression by cAMP Fig Comparison of the effect of H-89 on expression of the proglucagon and Cdx-2 gene promoter...

Ngày tải lên: 30/03/2014, 16:20

... shown to induce Akt activation in multiple cell types, including some human GBM cells [29-31] In this study, we investigated PI3K -Akt activation following irradiation in multiple GBM cell lines, ... signaling is the serine/threonine kinase Akt (also known as PKB) There are three closely related Akt isoforms in mammalian cells, including Akt1 (PKBα), Akt2 (PKBβ), Akt3...

Ngày tải lên: 09/08/2014, 10:20