Development of direct asymmetric aldol reactions mediated by primary amino acid derived organocatalysts exploring DNA cleaving activities of varacin b and varacin c

... Direct Asymmetric Vinylogous Reactions of Furanones and Phthalide Derivatives with Bifunctional and Trifunctional Organocatalysts Luo Jie (BSc, Zhejiang ... development of direct enantioselective vinylogous reaction of furanones and phthalide derivatives with bifunctional and trifunctional organocatalysis Chapter presents a brief historical background and ... Analytical data of vinylogous mannich adducts 103 Chapter Highly Diastereoselective and Enantioselective Direct Vinylogous Michael Addition of Phthalide Derivatives 4.1 Introduction 118 4.2 Vinylogous...

... arrangement by the influence of amino acids C266 and L268 These residues face the other side of this tyrosine and are members of a conserved loop (266CGLKG270) that shapes part of the FNR catalytic site ... interaction between the flavin, Y308 and the nicotinamide of NADP+ is precisely tuned by selecting amino acids that face the other side of the tyrosine phenol ring The specific volumes of the above-mentioned ... decrease in the catalytic efficiency of C266M and C266AL268A, respectively The correlation between the catalytic efficiency changes caused by the mutations and the different amino acid physicochemical...

... evaluate the therapeutic potential of expression vectors carrying the "A" fragment of the diphtheria toxin (DT -A) gene under the control of the H19 regulatory sequences in an ovarian carcinoma ... expression profiling allows an individualized DNA-base approach to cancer therapy The therapeutic potential of the DTA -H19 vector was tested in a rat animal tumor model for colorectal liver metastases ... effective antitumor agents Various gene therapy strategies for the treatment of ovarian cancer are currently under development and aim towards maximal treatment efficacy and minimal adverse effects...

... an approach for targeted therapy of bladder carcinoma by driving the DTA expression under the control of IGF2-P4 and H19 regulatory sequences To evaluate the possible use of IGF2-P4 and H19 regulatory ... therapy is an attractive approach Based on early studies of our group and others, the transcriptional regulatory sequences of the H19 and IGF2 genes emerged as candidates for cancer targeted therapy ... area of the malignant tissue of each bladder was determined by ImagePro Plus software Another healthy mice were used as control The total tumor area of each bladder was determined and the mean...

... the direct effect of adaptive abilities on health state utilities without controlling for mental health, and finally we checked if after controlling for mental health the direct effect of adaptive ... compensations for adaptation can be made List of abbreviations CAT: Cognitive Adaptation Theory; HRQL: Health Related Quality of Life; SF36: MCS Short-Form 36 Mental Component Scale; SF-36: PCS Short-Form ... public is often explained by adaptation [1,14] The results of this study show that adaptive abilities are indeed related to utilities, but that this effect is fully mediated by mental health for the...

... ANTI- TUMOR PROPERTIES OF LACTOBACILLI ARE MEDIATED BY IMMUNO- MODULATION AND DIRECT CYTOTOXICITY CAI SHIRONG B.Sc (Hons), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... the anti- tumor properties of LGG and compare it with that of other lactobacillus strains The study is divided into main areas: I Immuno- modulation by lactobacilli: To study the receptors and ... tumor growth in C3H mice [69] Aside from anti- tumor properties, lactobacilli also showed potential anti- metastatic properties as demonstrated by inhibition of lung and lymph node metastases by...

... method, which can transmit the view of forks’ environment in term of force feedback information, and we named it as observe-by-wire system The essential components of an OBW system are distance sensors ... Rossetter, Ian A Coe, J Christian Gerdes “Handwheel Force Feedback for Lanekeeping Assistance: Combined Dynamics and Stability,” American Society of Mechanical Engineers - Journal of Dynamic Systems, ... experiments are conducted by using this simulation and the haptic interface Fig The haptic interface is developed for the OBW system A fork system and working environment and control algorithm are...

... errors of seven subjects with OBW mode and without OBW mode From the research that has been carried out, we can conclude that: The concept of obsever -by- wire is given and a systematic study of observe- by- wire ... regardless to the height of masts, vehicle’s roof as well as intensity of illumination Therefore, the drive could also reduced risk of damaging the load and the warehouse by activating the OBW mode ... different sensitivity of each subject This paper has only been able to touch on novel technical solution for problems of forklift’s visuality and main features of an observe- by- wire system as well...

... method, which can transmit the view of forks’ environment in term of force feedback information, and we named it as observe-by-wire system The essential components of an OBW system are distance sensors ... Rossetter, Ian A Coe, J Christian Gerdes “Handwheel Force Feedback for Lanekeeping Assistance: Combined Dynamics and Stability,” American Society of Mechanical Engineers - Journal of Dynamic Systems, ... experiments are conducted by using this simulation and the haptic interface Fig The haptic interface is developed for the OBW system A fork system and working environment and control algorithm are...

... method, which can transmit the view of forks’ environment in term of force feedback information, and we named it as observe-by-wire system The essential components of an OBW system are distance sensors ... Rossetter, Ian A Coe, J Christian Gerdes “Handwheel Force Feedback for Lanekeeping Assistance: Combined Dynamics and Stability,” American Society of Mechanical Engineers - Journal of Dynamic Systems, ... motor distance information measured from an array of four sensors which are mounted on the left fork G : is the constant gain used to change the feedback force magnitude The need of constant gain...

... purify CDK4 Y17 kinases from HeLa cell extracts, and found that the cellular phosphorylation of CDK4 on Y17 is mediated by Src family kinases Results Detection of CDK4 Y17 phosphorylation and kinase ... that Y17 phosphorylation is mediated by Src family kinases is completely novel and it is interesting to note how this fits in with the previously published data CDK4 phosphorylation on Y17 is considered ... Roger PP & Coulonval K (2006) Regulated activating Thr172 phosphorylation of cyclin- Phosphorylation of CDK4 by Src family kinases dependent kinase 4( CDK4): its relationship with cyclins and CDK...

... tool for nations to regions in terms of developing climate change scenarios Developing climate change scenarios for small areas of Vietnam Based on software MAGICC / SCENGEN, we have built climate ... form of decades of the 21st century However, within the scope of this paper, we only introduce climate change scenarios that are summarized in the four main seasons in Vietnam Table Calculating ... data In combination with the observed data, SCENGEN can generate climate scenarios for any regions and any time period in the 21st century The baseline climate data used in the model is the period...

... protons into the matrix, bypassing F0 F1-ATPsynthase [6] The dotted line shows the result of the modeling after estimation of the unknown parameters The con- Modeling of ANT ditions of the described ... novel kinetic assay of mitochondrial ATPADP exchange rate mediated by the ANT Biophys J 96, 24902504 Metelkin E, Goryanin I & Demin O (2006) Mathematical modeling of mitochondrial adenine nucleotide ... in the same concentration range as in (A) Inset: a representative experiment showing the effect of the addition of cATR (in the concentrations indicated in the inset gure, in nM) on DWm, as indicated...