Activation of c h and c f bonds by cyclopentadienyl iridium complexes

... Cp*Ir(CO) (H) (p -C6 F4 CF3) OC F Ir F H F CF3 F 26 Cp*Ir(CO)(COOH)(p -C6 F4 CHO) OC F Ir F O OH F C F O H xii 27 Cp*Ir(CO)(COOH)(p -C6 F4 NO2) OC F Ir F O F OH NO2 F 28 Cp*Ir(CO) (H) [2,4 -C6 F3 (CN)2] OC NC Ir F H F CN F ... 14a = Rh 14b Cp*Ir(CO)(η2 -C6 F6 ) Ir CO F F F F F F x 16 [Cp*Ir (C6 F5 )(μ-CO)]2 O Ir Ir F F F O F F F F F F F 17 Cp*Ir(CO) (C6 F5 )Cl OC F Ir F Cl F F F 18a Cp*Ir(CO)(COOH)(p -C6 F4 CN) 18b Cp*Ir(CO)(COOMe)(p -C6 F4 CN) ... addition (Scheme 1.9) OC PEt3 PEt3 OC Fe N2 + HC H Fe CH OC C OC PEt3 Re2(CO)10 + CH PEt3 PhC CH CPh C hv (CO)4Re Re(CO)4 H H RhL4Cl + HC C C CH L L Rh H L C C C L C L Rh L L 2+ Cl- L L = PMe3 Scheme...

Tài liệu Báo cáo khoa học: Myristoylation of the dual-speciﬁcity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf

... 1. 2 Myristoylation was necessary for JSP1-induced activation of JNK 0.8 0.6 0.4 0.2 JSP1-wt JSP1-G2A JSP1-CS Fig JSP1 phosphatase activity was not dependent on myristoylation Recombinant JSP1-wt, ... regulator of the JNK signaling pathway [20, 21] Since myristoylation determined the subcellular localization of JSP1, we asked whether abrogation of myristoylation would also affect JSP1-induced JNK activation ... on the identiﬁcation of physiological substrates of JSP1, to reveal the mechanism underlying its effects on JNK signaling and 2470 whether this is linked to the observed triggering of apoptosis...

Báo cáo khoa học: Acute activation of Erk1/Erk2 and protein kinase B/akt proceed by independent pathways in multiple cell types ppt

... the involvement of PtdIns3K in Erk activation was the A20 B -cell line, which is explained by the role of PtdIns3K in activating Btk and PLCc, and subsequently activation of Erks [33] One of the ... Woodgett J & Dedhar S (1998) Phosphoinositide-3-OH kinasedependent regulation of glycogen synthase kinase and protein kinase B ⁄ AKT by the integrin-linked kinase Proc Natl Acad Sci USA 95, 11211–11216 ... dominant in determining cytokinedependent survival of cells Thus, we compared the apoptosis of the hemopoietic cells in the presence of PtdIns3K and MEK inhibitors to show that inhibition of...

báo cáo hóa học: " Aspirin-triggered lipoxin A4 attenuates LPSinduced pro-inflammatory responses by inhibiting activation of NF-B and MAPKs in BV-2 microglial cells" pptx

... as: Wang et al.: Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NFB and MAPKs in BV-2 microglial cells Journal of Neuroinflammation 2011 ... thereby enhancing excitotoxicity [41] IL-1b and TNF-a also drive self-propagating cycles of microglial activation and neuroinflammation by inducing activation of NF-B, cytokine generation and ... signal-regulated kinase; IL: interleukin; iNOS: inducible nitric oxide synthase; IκB: inhibitor of κB; JNK: c-jun N-terminal kinase; LPS: lipopolysaccharide; LX: lipoxin; LXA4: lipoxin A4; MAPK: mitogen-activated...

Báo cáo khoa hoc:" VEGF receptors on PC12 cells mediate transient activation of ERK1/2 and Akt: comparison of nerve growth factor and vascular endothelial growth factor" doc

... demonstrated that VEGF1 65 induced transient activation of ERK1/2 and Akt after In contrast, NGF produced a stronger and persistent phosphorylation of ERK1/2 and Akt than VEGF1 65 much more pronounced ... Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells Comparison of the effects of nerve growth factor and epidermal growth factor ... effect on PC12 cell proliferation and neurite formation One reason might be endogenous VEGF- expression of proliferating PC12 cells which is downregulated only 48 h after induction of differentiation...

Báo cáo y học: " Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B" pps

... signaling pathway To determine the role of NTHi-induced p38 MAPK and NF-kappa B activations in NTHi-induced COX-2 and PGE2 expression, the effects of p38 MAPK inhibitors SB203580 and SB202190 and NF-kappa ... MAPK inhibitors and NF-kappa B inhibitor The findings in the present study clearly demonstrate that the activation of p38 MAPK and NF-kappa B is involved in the regulation of COX-2 and PGE2 in ... induces COX-2 and PGE2 expression in a p38 MAPK and NF-kappa B-dependent manner through TLR2 in lung epithelial cells in vitro and lung tissues in vivo The full understanding of the role of endogenous...

Báo cáo y học: "High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury" docx

... surfactant-depleted lung injury) for both groups consisted mainly of macrophages The proportion of neutrophils in the first BAL fluid was ...

Understanding cofactor f420 dependent mechanism(s) in the activation of bicycle nitroimidazoles and in the physiology of mycobacterium tuberculosis

... reduction of the cofactor F420H2 is the active form of the cofactor that is utilized by Ddn (Figure 1.3) The physiological role of both cofactor F420 and the activating enzyme Ddn in Mtb is unknown ... described in this thesis Before detailing the objectives of the thesis in section 1.6, the following is a brief description of the ten compounds in the pipeline 15 A B Figure 1.2 The Global Pipeline ... developed Binding affinity of PA-824 to Ddn was monitored through intrinsic fluorescence quenching of the protein facilitating an enzymatic turnover-independent assessment of affinity The results...

Tài liệu ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 docx

... Page of 51 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION NUMBER ... Page of 51 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION NUMBER ... Page of 51 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION NUMBER...

Tài liệu Báo cáo khoa học: Identiﬁcation of b-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay docx

... vector MS fragmentations of entries A and B are shown in the lower panel CYP93E1 has 24-hydroxylase activities for both b-amyrin and sophoradiol substrates b-amyrin and sophoradiol hydroxylase ... production of not only ﬂavonoid but also of triterpene saponins is induced by elicitation as mentioned above, triterpene hydroxylase is one possible function of CYP93E1 Feeding of b-amyrin and sophoradiol ... would be improved by in situ supply of the substrate through coexpression with b-amyrin synthase In our previous studies, more than 10 mg of b-amyrin was produced by 1-L culture of yeast transformant...

Báo cáo khoa học: Small heat shock protein Hsp27 prevents heat-induced aggregation of F-actin by forming soluble complexes with denatured actin docx

... complexes of small HSP with denatured actin Fig Formation of the complexes of denatured actin with Hsp273 D as studied by DLS (A) F -actin (0.5 mgÆmL)1) was heated at a constant rate of C°Æmin)1 ... analysis of the complexes of Hsp273 D with thermally denatured actin The complexes were obtained by heating of F -actin (0.5 mgÆmL)1) to 75 °C at a constant rate of C°Æmin)1 in the presence of 0.1 ... case of F -actin, is presented as soluble and relatively small complexes formed by sHSPs with denatured actin molecules obtained during the heating of F -actin In conclusion, the analysis of the...

Báo cáo khóa học: Membrane transport of fatty acylcarnitine and free L-carnitine by rat liver microsomes pot

... detectable levels in liver microsomes [4], so at present it is not clear how inward and outward transport of fatty acylcarnitine and L-carnitine, respectively, across the ER membrane are facilitated ... Isolation of microsomes from rat liver way envisaged in Fig there must additionally be a means whereby the L-carnitine product can escape from the ER and there must be a supply of ER luminal free ... process at 10 °C of nmolÆ min)1Æmg)1 with a Km of 0.53 mM (the rate of exchange transport was much faster) [36] Even relative to total Ó FEBS 2004 Transport of carnitine and acylcarnitine (Eur...

AN IMPACT EVALUATION OF EDUCATION, HEALTH, AND WATER SUPPLY INVESTMENTS BY THE BOLIVIAN SOCIAL INVESTMENT FUND pptx

... Lavy and others 1996, Mwabu and others 1993), and drinking water (Brockerhoff and Derose 1996, Lee and others 1997) The main conclusions of the study are as follows Although the social fund improved ... Because the worst-off and best-off schools were excluded from the randomization and the sample, the study’s findings on the impacts of the sif cannot be generalized to all schools 246 the world bank ... because of financial constraints Thus by the time of the follow-up survey some clinics had received an interven- Newman and others 253 tion and some had not Thanks to the financing from the German...

Báo cáo khoa học: Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b pptx

... Journal compilation ª 2006 FEBS Modulation of Ca2+ entry by TRPM4b R Fliegert et al A B Fig Ca2+ activation and localization of TRPM4b Activation of TRPM4b by Ca2+ was analyzed in patch clamp ... 707 Modulation of Ca2+ entry by TRPM4b R Fliegert et al A B Fig Ca2+ release and Ca2+ entry induced by ionomycin in TRPM4b- expressing HEK-293 cells The cells were loaded with Fura2 ⁄ AM, and [Ca2+] i ... Modulation of Ca2+ entry by TRPM4b R Fliegert et al phosphorylation by protein kinase C, and binding of Ca2+ calmodulin and phosphatidylinositol 4,5-bisphosphate [8,9] Nilius et al observed Ca2+- dependent...

Báo cáo khoa học: Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D doc

... Proteolysis of CT within hepatic endosomes at acidic pH We next examined the ability of hepatic endosomes to degrade CT (Fig 2) The luminal and membrane- bound distribution of endosomal CT-degrading ... 2005 FEBS 4387 Endosomal proteolysis of cholera toxin by cathepsin D pH Intermediate peptide peaks were only observed at pH in addition to the undegraded subunits which had decreased in peak height ... compared the rate of hydrolysis of the individual CT-A and CT-B subunits by cathepsin D at pH 4, followed by nonreducing SDS ⁄ PAGE and Coomassie Blue staining (Fig 7B) Pure cathepsin D was found...

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Từ khóa: 63 confusing scope and activation of member new and delete local activation of cdmp 1 and its receptors in olf activation of rnase h activation of t lymphocytes and other signaling events in hematopoietic cells prevent moderate trauma induced activation of cascade systems and coagulation road maps to the activation of ras mapk and pi3k akt erk1 2 to the activation of ap 1 and nf il 6 but not of nf kb 10 8 analysis of variance table and an f test of the regression model diseases of the stomach and intestines are handled by a specialist in which system how is the development of childrens oral and written language supported by childrens literature evolving opportunities for management of agricultural landscapes and ecosystem health sustainability by opportunity enhanced mismatch mutation analysis simultaneous detection of point mutations and large scale rearrangements by cap the selective determination of sulfates sulfonates and phosphates in urine by capillary electrophoresis mass spectrometry mechanisms of calcium associated exocytosis of striatal dopamine and dopa release studied by in vivo microdialysis modulation of epithelial function and local immune system by probiotics mechanisms involved Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thống Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt nam Nghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấp Biện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọ Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Quản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninh Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ long Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùng Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chế Nghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúng Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tin Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khí Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIX Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt nam TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ