local activation of cdmp 1 and its receptors in olf

... viscous time units), showing an LC2 state at Re = 2700 and (a) Λ = 1. 739, (b) Λ = 1. 728 and (c) Λ = 1. 716 10 1 Fig 5.32 Hot-film data (time series over minute and corresponding the amplitude of the FFT ... vertical lines indicate the Hopf frequencies of the three most dangerous modes of the basic state at Re = 2600, as determined by Lopez et al 20 01, where ωH1 = 0 .16 92, ωH2 = 0 .11 35 and ωH3 = 0. 218 1 14 4 ... and Huassling (19 82), Lugt and Abbound (19 87), Neitzel (19 88), Lopez (19 90), Brown and Lopez (19 90), Tsitverblit (19 93), Sørensen and Christensen (19 95), and Gelfgat et al (19 96) Lopez (19 90) depicted...

Ngày tải lên: 14/09/2015, 14:02

... Cathepsin Ba Papaina 0 .17 0.05 0.35 0 .15 0.30 0 .15 33 13 36 15 > 10 0 > 10 0 1. 4 0.4 0. 31 10 > 10 00 1. 1 20 11 4.8 3.7 0.57 12 3.2 1. 6 0. 011 0.0 016 a [13 ] b 1. 4 0.7 0.2 3.5 0.6 0.6 0.3 ... SD [nM] 10 4 ã kdiss [s )1] 10 )6 ã kass [M )1 s )1] Cathepsin F Cathepsin K Cathepsin V Cathepsin S Cathepsin H Cathepsin C Cathepsin X Papain Cathepsin La Legumainb Cathepsin Ba Papaina 0 .17 0.05 ... slow binding inhibitor of the cathepsins, characterized by kass values in the range of 10 6 )10 7 m )1, and high kdiss values in the range of 10 )3 to 10 )4 for the tightly inhibited cathepsins F, K and...

Ngày tải lên: 19/02/2014, 17:20

... IL -10 IL -12 IL -13 IL -17 G-CSF GM-CSF MCP -1 MIP -1 IFN-γ TNF-α + LMP-420 (1 µM) 15 , 829 ± 75 24 ± 582 ± 54 7±3 16 , 512 ± 19 0 26 ± 17 ,16 0 ± 2 21 1,963 ± 17 51 ± 44 ± 80 ± 2,8 61 ± 98 93 ± 2, 714 ± 13 2 ... 2, 714 ± 13 2 19 ,554 ± 63 424 ± 7,628 ± 11 2 10 ,670 ± 2 71 18 ± 419 ± 13 3 1 17,249 ± 10 3 24 ± 17 ,575 ± 262 1, 766 ± 62 76 ± 33 ± 56 ± 4,794 ± 803 63 ± 14 3 ± 19 ,12 7 ± 520 262 ± 654 ± Percent Inhibition ... http://www.aidsrestherapy.com/content/3 /1/ 8 report of 12 cases of reactivation of latent M Tb in patients in California being treated with TNF antagonists, 11 of the patients were being treated with infliximab [13 ] Since infliximab...

Ngày tải lên: 10/08/2014, 05:20

... 8,879.37 11 ,12 1.66 1. 25 He et al Journal of Biomedical Science 2 011 , 18 :22 http://www.jbiomedsci.com/content /18 /1/ 22 Page of 10 Figure Regulation of miR -1 and miR -13 3a by IPost MiR -1 and miR -13 3a ... rno-miR -1, NR 03 211 6 .1; rno-mir -13 3a, NR 0 318 79 .1) and AMOs (AMO -1 and AMO -13 3a) were synthesized by Jima Inc (Shanghai, China) The sequences of miRNA mimics and AMOs are showed in Table Mimic and ... miR -1 and miR -13 3a were down-regulated in MI [14 ] MiR -1 and miR -13 3 produced opposing effects on apoptosis induced by H2O2 [15 ] MiR-320 was down-regulated, while miR- 21, miR -14 6b and miR-4 91 were...

Ngày tải lên: 10/08/2014, 05:21

... 14 54 ± CCRT K4

Ngày tải lên: 12/08/2014, 04:21

... 14 54 ± CCRT K4

Ngày tải lên: 12/08/2014, 04:21

... complexity in Drosophila Nature 2003, 426(6968):849-53 Page 13 of 15 (page number not for citation purposes) Algorithms for Molecular Biology 2007, 2 :13 10 11 12 13 14 15 16 17 18 19 20 21 22 23 ... 0.052 0 .13 2.6 1. 7 1. 2 1. 6 3.8 2.9 3.4 2.8 3.6 1. 7 Median 8.62E-04 5 .1 Median 0 .19 6 4.4 Median 0 .11 28 2.6 Comparison of minimal p-values and best found cutoffs for bicoid PWM calculated (i) in regulatory ... 0.00025 6.54E-06 0. 012 0.0044 0. 013 0.00026 5.8E-06 0. 010 0.0033 0. 012 3.6E-05 4.34E-07 1. 00 1. 01 0.99 0.99 1. 13 1. 10 1. 34 1. 04 7 .10 7 .13 Comparison of p-values calculated for the Markov(0) model by...

Ngày tải lên: 12/08/2014, 17:20

... 4.3 Results 10 1 4.4 Discussion 11 2 References 11 5 CHAPTER BAICALIN REDUCES MITOCHONDRIAL DAMAGE STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS IN 11 7 Abstract 11 8 5 .1 Introduction 11 9 5.2 Materials ... haemotoxylin staining The intact Langerhan Islets explain the increase in plasma and pancreatic insulin contents despite the administration of STZ Scale bars indicate 10 0µm 10 Figure 4 .1 The ROS ... endocrine role of the pancreas in metabolism and the existence of insulin were not fully clarified until 19 21 Sir Frederick Grant Banting and Charles Herbert Best repeated the work of Von Mering and...

Ngày tải lên: 12/09/2015, 10:58

... DESCRIPTION OF EXPERIMENT Fig 2 .1 Schematic drawing of the overall experimental setup 23 CHAPTER DESCRIPTION OF EXPERIMENT Fig 2.2 Schematic drawing of the confined cylinder setup On top of the cylinder, ... cylinder wall is too thick to allow efficient heat exchange between the fluid inside the cylinder and its surroundings, there is a gradual rise in the temperature of the fluid, resulting in an increase ... crosssectional) viewing of the flow structure, was illuminated using a thin laser sheet (about 1. 5mm) produced by directing a 5W Argon ion laser beam through a cylindrical lens (see Fig 2 .1) In all cases,...

Ngày tải lên: 14/09/2015, 14:02

... 7.4323 × 10 -5 -7 .11 61 × 10 -3 0.53774 -0. 516 56 16 0, 400 (t = 0. 01) (0 .18 1, 1. 956) (0.763, 0.800) (0.2 31, 2.038) (0.3 31, 2.2 81) 60, 15 0 (t = 0.05) (Lopez and Shen, 19 99) 12 0,300 (t = 0. 01) (Lopez and ... -7.0842 × 10 -3 0.53006 -0. 510 90 90, 225 (t = 0.025) (0 .17 8, 1. 956) (0.767, 0.800) (0.233, 2.033) (0.333, 2.278) 7.3326 × 10 -5 -7 .10 17 × 10 -3 0.534 71 -0. 513 78 12 0, 300 (t = 0. 01) (0 .17 5, 1. 958) (0.758, ... values and locations of three local maxima and minima of ψ and η at H/R = 2.5 and Re = 2494 with constant rotating speed The finite differential results by Lopez and Shen (19 99) are also included in...

Ngày tải lên: 14/09/2015, 14:02

... geometry into a spiral trajectory as can be seen in Fig 4 .11 (b) Further increased in eccentricity to ε/R = 0 .10 and 0.20 produced similar results (see Figs 4 .11 (c) and 4 .11 (d)), but with increasing ... operating at 20,000 steps/rev with an adjustable speed of up to 240 rpm (Ω = 25 .1 rad/s), and an error of less than 0 .1% The working fluid was a mixture of glycerin and water (about 80% of glycerin ... bottom wall Fig 4 .12 Vortex structures obtained using identical flow conditions as in Figs 4 .11 (b) and 4 .11 (d) Here, some background dye has been introduced in the flow domain prior to the experiment...

Ngày tải lên: 14/09/2015, 14:02

... time units), showing an LC1 state at Re = 2700 and (a) Λ = 1. 716 and (b) Λ = 1. 757 (a) 10 minutes 0.2 0.08 Amplitude Hot-film output 0 .1 0.0 -0 .1 -0.2 20 40 0.04 0.00 60 0.29 t (s) f (b) 15 minutes ... series over minute and corresponding the amplitude of FFT results) showing the evolution to an LC1 state at Λ =1. 733 taken (a) 10 minutes, (b) 20 minutes, and (c) 25 minutes after starting gradually ... shown in the figure At Λ = 1. 693 at Re = 2745, LC1 was the mode that emerged following an impulsive start from rest By increasing Λ in quasi-steady increments from Λ = 1. 716 to 1. 739 to 1. 762 to 1. 78,...

Ngày tải lên: 14/09/2015, 14:02

... A in the power at ωn and ωf are shown in Fig 6 .11 12 1 CHAPTER QUENCHING OF UNSTEADY VORTEX BREAKDOWN Fig 6.9 (a) Phase portraits in the neighborhood of the 2 :1 resonance for QP at ωf /ω0 ≈ 0 .19 65 ... and v have odd parity To avoid including the origin in the collocation mesh, an odd number of GaussLobatto points in r is used and the equations are solved only in the interval [0, 1] Following ... boundary layer increase in amplitude and decrease in wavelength 13 1 CHAPTER QUENCHING OF UNSTEADY VORTEX BREAKDOWN Fig 6 .18 Computed streamlines of LCF over one forcing period 2π/ωf (time increases...

Ngày tải lên: 14/09/2015, 14:02

... steady and very much like that in the A = basic state shown in Fig 7 .1 140 CHAPTER HARMONICALLY FORCING ON A STEADY SWIRLING FLOW (a) ωf = 0 .17 1 t=0 4.49 8.97 13 .46 17 .95 22.44 26.92 31. 41 35.90 ... modes of the basic state at Re = 2600, as determined by Lopez et al 20 01, where ωH1 = 0 .16 92, ωH2 = 0 .11 35 and ωH3 = 0. 218 1 Hence, it is conjectured that these other spikes in Fig 7.5 are 1: 1 resonances ... stability 14 2 CHAPTER HARMONICALLY FORCING ON A STEADY SWIRLING FLOW analysis by Lopez et al (20 01) The three vertical dotted lines in Fig 7.5 correspond to ωf = ω0 = 0 .16 92, ωf = 1 = 0 .11 35, and...

Ngày tải lên: 14/09/2015, 14:02

... our understanding of the flow physics in the confined cylindrical container with one rotating endwall, there are still some issues that need to be addressed and explored The following are recommendation ... swirling flow”, Physics of Fluids, Vol 18 , No 10 410 6, October 2006 J.M Lopez, Y.D Cui, F Marques and T T Lim, “Quenching of vortex breakdown oscillations via harmonic modulation”, Journal of Fluid ... T.T Lim and F Marques “Harmonically forced enclosed swirling flow”, submitted to Physics of Fluids, 2008 15 9 PUBLICATIONS 16 0 ACHIEVEMENT LIST OF RELATED ACHIEVEMENT Y.D Cui, Winner of Andrew...

Ngày tải lên: 14/09/2015, 14:02

... Cosmetics and the ‘Picts’ Conclusion 10 2 10 4 11 2 11 5 12 1 12 6 13 5 13 9 Hair and Head Introduction Gendering the Head Colours and Humours Colour, Texture, Climate and Inheritance Periwigs and the ... (15 28 -15 86), Samuel Tissot (17 28 -17 97) and Johann Caspar Lavater (17 41- 18 01) were Swiss, Cesare Ripa (15 60 -16 45) and Bernardino Ramazzini (16 33 -17 14) were Italian, and Henrick van Deventer (16 51- 1724) ... pages 16 leaves = 32 pages 18 leaves = 36 pages (4o) (8o) (12 o) (16 o) (18 o) Currency shilling (1s) = 12 pence (12 d) I pound ( 1) = 20 shillings (20s) I guinea = 21 shillings (21s., or 1 1s) Introduction...

Ngày tải lên: 18/11/2015, 09:55

... proinflammatory cytokines Genes Dev 15 , 14 19 14 26, doi :10 .11 01/ gad.8885 01 Ip YT & Davis RJ (19 98) Signal transduction by the c-Jun N-terminal kinase (JNK)—from in ammation to development Curr Opin ... 297, 10 18 10 23, doi :10 .11 26/science .10 68873297 ⁄ 5583 ⁄ 10 18 [pii] 11 Hornberg JJ, Bruggeman FJ, Binder B, Geest CR, de VaateAJ, Lankelma J, Heinrich R & Westerhoff HV (2005) Principles behind ... 408 .19 344 .19 268.23 382.27 439.29 Myr-Gly Asn Gly 579.26 465. 21 515 .26 4 01. 21 MH+ MH+- 846.48 636.37 700.37 Asn Lys 2 61. 16 14 7 .11 CH3SOH 782.47 b3 439.29 y2 2 61. 16 y5CH SOH y3 515 .26 408 .19 %...

Ngày tải lên: 16/02/2014, 14:20

... 2, pUC19 and 10 mM DTT; lane 3, pUC19 and lM FeCl3; lane 4, pUC19, 10 mM DTT, and lM FeCl3; lane 5, pUC19, 10 mM DTT, lM FeCl3, and 50 lgÆmL )1 rBcp2; lane 6, pUC19, 10 mM DTT, lM FeCl3, and 50 ... pernix APE2278 [10 ] and Pyrococcus horikoshii PH1 217 [11 ,12 ] have A H2O 1- Cys Prx 1- Cys Prx H2O2 Sp OH 722 Identification of the bcp2 gene encoding putative peroxiredoxin The analysis of the complete ... plasmid and a virus Mol Microbiol 34, 217 –226 29 Bradford M (19 76) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding...

Ngày tải lên: 07/03/2014, 12:20

... HIP -1 interacts with its paralog HIP1-R, subunits of clathrin-associated adaptor protein (AP) complex AP2A1 and AP2A2, clathrin heavy chain (CLH1), and clathrin heavy chain (CLH2), clathrin light ... Conclusions HIP -1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor of HIPPI, and the wild-type N-terminal Htt, which interacts ... or death ligand In addition, the expression of BLOC1S2 is increased in some tumors [34] Information on the interacting partners of HIPPI such as HIP -1, Homer 1c, BAR and apoptin indicates that...

Ngày tải lên: 23/03/2014, 07:20

... in Table Table Experimental design for RSM approach Coded variables X3 X1 X2 0 0 -1. 414 2 0 1. 414 2 0 1 -1 -1 -1 -1 -1 -1 -1 -1 0 -1. 414 2 0 1. 414 2 -1. 414 2 0 10 -1 1 11 0 1. 414 2 12 -1 -1 -1 13 1. 414 2 ... 15 .3 15 .9 15 .3 15 .9 15 .8 16 .9 16 .1 16.8 16 .4 16 .5 day after 13 .8 13 .7 13 .9 13 .9 13 .9 14 .9 15 .1 15.4 15 .5 15 .6 15 .3 16 .5 15 .7 16 .5 HRY, % 20.2058 15 . 916 2 16 .0557 31. 5667 37.2008 29. 514 5 29.5 714 ... 24 .1 17.7 16 .1 55oC 23.4 18 .3 16 o 10 55 C 11 o 50 C 12 o 50 C 13 o 45 C 14 o 45 C 24.7 26.3 23.5 25.5 23.5 25.7 24.3 23.7 22.9 23 24 .1 18 .1 17.9 17 .8 18 .6 18 .4 18 .7 17 .8 17 .8 18 .2 17 .5 19 15 .2...

Ngày tải lên: 21/06/2014, 06:20