Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 1
Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 1
... Role of Superoxide anion in Cancer 55 PROSTATE CANCER 1. 6 .1 1.6.2 1. 6.3 AIM OF STUDY MATERIALS 2 .1. 1 2 .1. 2 2 .1. 3 2 .1. 4 2.2 GROWTH-FACTOR REGULATION OF CELL SURVIVAL 3 .1. 1 3 .1. 2 3 .1. 3 3 .1. 4 3 .1. 5 ... Bad-dependent 11 6 RSK1 is the Bad kinase activated by EGF in LNCaP cells 12 1 iv 3 .1. 8 3 .1. 9 3 .1. 10 3.2 Role of ErbB receptors in EGF- and serum-mediated survival of LNCaP cells 13 0 Bax ... apoptosis in LNCaP cells 13 8 Serum promotes cell survival in LY-treated LNCaP cells via inhibition of Bad and Bax translocation .14 1 REACTIVE OXYGEN SPECIES REGULATION OF CELL SURVIVAL 3.2 .1 3.2.2...
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Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 2
... SERUM-MEDIATED SURVIVAL IS INDEPENDENT OF MEKERK- AND PI3K-AKT -INDEPENDENT PATHWAY IN LNCAP CELLS Although both EGF and serum inhibited LY-induced apoptosis in LNCaP cells, analysis of survival signaling involved ... PI3K-AKT -INDEPENDENT SURVIVAL PATHWAY(S) IN LNCAP CELLS The PI3K-Akt pathway has been proposed to be the major survival pathway in LNCaP cells due to PTEN inactivation in this PCa cell line (Lin et ... supporting the essential role of O2·− in regulation of LNCaP cells sensitivity to apoptosis by LY This is in line with other recent findings that have demonstrated that an increase in intracellular...
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Investigating the superoxide mediated survival pathway in the prostate cancer cell line LNCaP
... result in cell death The delicate redox balance is kept in check, and is often the deciding factor in determining cell fate in these cancer cells 1.6 PROSTATE CANCER Prostate cancer, the cancerous ... classified under the extrinsic and intrinsic pathway The extrinsic pathway involves the direct transduction of an external signal that activates apoptosis The intrinsic pathway is mediated by the mitochondria, ... of the proteins are designated and the bold lines define the BH domains ‘TM’ marks the hydrophobic transmembrane domain Bcl-2 proteins play an important role in determining cell fate and survival, ...
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Báo cáo khoa học: Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast ppt
... analysis of Lsm1 p showing the importance of residues proposed to be involved in RNA binding and complex formation, and of the C-terminal region for the func- Lsm1 and -8 domains involved in localization ... N- and ⁄ or C-terminal domains, exchanged the central Sm domains or, in the case of Lsm8 p, made point mutations in putative RNA-binding residues We investigated the cellular localization of GFPtagged ... in 5–20% of cells under stress conditions (Fig 5B), suggesting that the N-terminal domain of Lsm1 p is sufficient in combination with the Sm and C-terminal domains of Lsm8 p (i.e presumably in the...
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An Analysis of Business Administration Students Interest in the area of production and Operations pot
... Lima, Dorelland P and Andrade, Raphael J C.: An Analysis os Business Administration Students Interest in the Area of Production and Operations Journal of Operations and Supply Chain Management ... Costa, Francisco J., Lima, Dorelland P and Andrade, Raphael J C.: An Analysis os Business Administration Students Interest in the Area of Production and Operations 90 Journal of Operations and Supply ... Costa, Francisco J., Lima, Dorelland P and Andrade, Raphael J C.: An Analysis os Business Administration Students Interest in the Area of Production and Operations 96 Journal of Operations and Supply...
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báo cáo hóa học:" Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter" pptx
... al.: Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor ... resulted in finding a total of 42 genes common to both (Additional file 10) In order to begin to understand the significance of the genes common to the three microarray studies in the ovary, we then ... the prolactin receptor which is localized to granulosa cells as well as other cell types in the rat ovary [46] Prolactin receptor expression in rat granulosa cells is increased by treatment of...
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Báo cáo y học: "Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren’s syndrome" pptx
... daily at the time of analysis After developing parotid gland enlargement, lymphoma of the parotid gland was excluded by partial parotidectomy and histological examination After approval by the ... typically present in sera of patients with SS [18] and was also detected in the saliva or in salivary gland biopsies [19] of these patients In this regard, Martin et al described two salivary ... is inline with the assumption that plasma and memory B cells accumulate in the parotid gland but cannot clarify the origin of these cells Whatever the primary aberration in the induction of the...
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Báo cáo y học: " Molecular analysis of HBV genotypes and subgenotypes in the Central-East region of Tunisia" potx
... al.: Molecular analysis of HBV genotypes and subgenotypes in the Central-East region of Tunisia Virology Journal 2010 7:302 Submit your next manuscript to BioMed Central and take full advantage of: ... NH and OB conceived of the study, participated in its design, and in drafting the manuscript HT and JB participated in the study design and coordination and in discussing manuscript NH, NBF and ... suggested the predominance of this new subgenotype in the region [23,28] Subgenotype D1 is Page of predominant in the Eastern part of Africa; Saudy et al described it in Egypt [29] Our region geographically...
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Báo cáo y học: " Analysis of repetitive DNA distribution patterns in the Tribolium castaneum genome" pptx
... comparisons, analysis of these regions indicates a noticeable reduction in the rate of recombination in regions containing a high density of repetitive DNA, supporting our hypothesis that these regions ... Density distribution of repetitive DNA on each chromosome of T castaneum Density and distribution of repetitive DNA on each chromosome of T castaneum The total length (kb) of repetitive DNA in each ... if the regions accumulating repetitive DNA are derived from heterochromatin, then they might contain fewer genes than the repetitive DNA- poor intervals To test this hypothesis, the density of...
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FUNCTION AND REGULATION OF CALCIUM INDEPENDENT PHOSPHOLIPASE a2 IN THE ATTENUATION OF PAIN IN MICE
... sometimes 2.1 Orofacial pain Orofacial pain is defined as pain within the structures of the oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders ... revealed that pain is one of the main reasons that patients look for medical attention and that the lifetime prevalence of pain indications such as back pain, chest pain, headache and joint pain is around ... neuropathic pain in mice, further highlighting the involvement of DHA and its metabolites in mediating neuroinflammation and pain (Yacoubian and Serhan, 2007; Nakamoto et al., 2010; Xu et al., 2013) Pain...
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Distribution and role of calcium independent phospholipase a2 in the brain
... is the cessation of blood flow to the brain and disruption of metabolic demand During early stages of ischemia (within min), inositolcontaining glycerophospholipids are the main source of the increase ... define the physiological role of sPLA2 and ascertain its contribution in the inflammatory process 1.2 cPLA2 isoforms The cPLA2 family consists of six intracellular enzymes, cPLA2α, cPLA2β, cPLA2γ, ... class of phospholipase A2 (PLA2) that does not require calcium for its activity is the cytosolic calcium- independent PLA2 (iPLA2) In brain tissues, the basal expression and activity of iPLA2 is...
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Molecular analysis of maternal diabetes induced changes in the developing neural tube
... in e A III LV E B dc dc e vtw vtw E C vt dt D Fig Thickness of Ventral Telencephalon Wall (µm) 300 250 * 200 150 100 50 Fig Control Diabetic vt dt vt vt A B Fig % of BrdU-cells in Ventral ... vt B e A Fold of induction 3.5 ** 2.5 1.5 0.5 Control Diabetic B 333bp C Fig dc dc III vt A vt B LV A Fig dc e dc III vt vt LV A Fig dt B III e e e dc vt LV A Fig 10 B A Fold of induction 1.5 ... TGF-ß l TGF-ß l III III E F TNF-α III G Fig 17 TNF-α G III H Lectin TGF-ß1 A B C Lectin TNF-α III D Fig 18 TGF-ß1+Lectin TNF-α+Lectin III III E F tm III htms III htm A Fig 19 B 50 Mean Cell numbers/mm...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... to bind lipid compounds within the different endolysosomal compartments [23] In this study, we examined whether iron loading of the liver epithelial cell line HepG2 in uenced the expression of ... stress, cell growth and lipid metabolism in the iron loaded HepG2 The results of the study revealed a new link between iron loading and lipid accumulation, leading to upregulation of CD1d molecules ... background staining (thin lines) Cells were then acquired in a FACScalibur and analyzed using CELLQUEST (A) Histograms show the expression of the molecules studied in HepG2 cells cultured in the absence...
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Báo cáo khoa học: Role of peroxidase inhibition by insulin in the bovine thyroid cell proliferation mechanism pdf
... responsible for the decrease of thyroid hormone biosynthesis in primary cultures in the presence of insulin In addition, our data suggest that insulin stimulates cell division, in bovine thyroid cultures, ... significant increase in concentration of the peroxidase inhibitor by the action of insulin, during 48 h, in thyroid primary cultures with 0.1% fetal bovine serum, totally depleted of the hormone, 48 ... results, without discarding the anti-apoptotic effect of insulin [24], demonstrate that both insulin and the peroxidase inhibitor, in the absence of TSH, stimulate cell growth of thyroid cultures Conversely,...
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Báo cáo sinh học: " Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line" docx
... that anti-RSV IgG incubation induced the removal and re-appearance of intracellular viral pro- Figure Confocal laser scanning image of intracellular RSV proteins Confocal laser scanning image of ... HEp-2 cells, anti-RSV IgG was added, and cell viability was determined at 2, 24, 48, and 72 h of incubation Sterile 0.2% ethylenediamine tetra acetate (EDTA) in 0.9% saline was added to each cell ... times in sucrose medium permeabilized and fixed, in acetone and methanol Confocal laser scanning was used to obtain images of intracellular viral proteins visualized as described in Figure Page of...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ