Role of promyelocytic leukemia (PML) and small ubiquitin like modifier (SUMO) proteins in alternative lengthening of telomeres

... modifications of a protein may also involve the attachment of other proteins or peptides, such as ubiquitin and the small ubiquitin- like modifier (SUMO) Subsets of a pool of proteins may be modified ... according to the cellular conditions and microenvironment as part of the cellular response and regulatory processes 1.1.1 Small Ubiquitin- like Modifier...

Ngày tải lên: 11/09/2015, 10:18

... depending on the differentiation direction and degree of maturation 1.2 Acute Promyelocytic Leukemia (APL) Acute promyelocytic leukemia (APL) accounts for 10 – 15 % of acute myeloid leukemia (AML) and ... 3.3.2 Anti-proliferative activity of curcumin and analogs on leukemic non-APL cell lines 91 3.3.3 Anti-proliferative activity of curcumin and...

Ngày tải lên: 11/09/2015, 14:20

... CcTopII, CcPCNA and CcUbc9 are all present at meiotic prophase in Meiosis and Ubc9 C cinereus and that each of CcLim15, CcTopII, CcPCNA and CcRad51 has the potential to interact with CcUbc9 Moreover, ... in meiosis In C cinereus, however, because CcPCNA and CcUbc9 exist together in meiotic nuclei, 3526 the interaction between CcPCNA and CcUbc9 and sumoylation may occur at...

Ngày tải lên: 07/03/2014, 09:20

... and network- based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression Rotem Ben-Hamo1 and Sol Efroni1,* The Mina and Everard ... over pathway behavior and may serve as a potential therapeutic target for Glioblastoma patients Drug target analysis Over the past 25...

Ngày tải lên: 11/08/2014, 12:21

... specificity of anti -HCV antibody responses in patients suffering from chronic HCV infection The specificity of anti -HCV antibody responses in patients suffering from chronic HCV infection A The ... using recombinant HCV core, NS3, NS4B or NS5A proteins, which represent the major immunogenic proteins of HCV (see below) There was some faint staining in...

Ngày tải lên: 12/08/2014, 04:21

... plasma cytokines after flagellin administration Cytokines were quantified by ELISA in plasma at baseline (time 0), at one, three and six hours after μg flagellin, and at one and three hours after ... expressed in mouse organs in vivo, that flagellin elicits prototypical innate immune responses in these organs, and that it also activates apoptotic signaling, pred...

Ngày tải lên: 13/08/2014, 21:21

... innovation Small firms are the great innovators in some industries, while large firms are the great innovators in others Moreover, small and large businesses interact in innovative activity The ... businesses There is no clear evidence that small businesses are more effective innovators Further, the innovations of both small businesses and large busi...

Ngày tải lên: 06/03/2014, 19:20

... activity of HL-60 Cells Utilizing the induced differentiation of HL-60 promyelocytic leukemia cells as a model of myeloid maturation, we examined the expression and location of Rac and PAK The interaction ... cells induced with ATRA Induction of Rac and PAK HL-60 cells were treated with lM ATRA for a week, and Rac and PAK were assayed in both cytoso...

Ngày tải lên: 31/03/2014, 15:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... activation of Aur-A and induces monopolar spindle in NB4-R2 cells (A) VX-680 inhibited phosphorylation of AurA at Thr288 in NB4-R2 cel...

Ngày tải lên: 18/06/2014, 19:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In...

Ngày tải lên: 20/06/2014, 03:20

... that p 21/ waf1 and cyclin D2 are complexed together in HTLV -1 infected cells Cell cycle analysis of cyclin D2 and p 21/ waf1 p 21/ waf1 has been previously described as an assembly factor for cyclin ... Cyc D2 CDK2 + CycE + p 21/ waf1 (WT, 10 0ng) D) CDK4 + Cyc D2 CDK2 + CycE B) CDK4 + CycD2 + p16/INK4A CDK4 + CycD2 + p 21/ waf1 (mut) CDK4 + CycD2 + p 21/...

Ngày tải lên: 13/08/2014, 13:20

... Shizuoka and the lower rank three: Okinawa, Miyazaki and Nagasaki Japan consists of 47 prefectures) by using statistical data on the size of the enterprise and prefectural income (typical index that ... The Ministry of Health, Labour and Welfare) This means that SMEs have played an important and constant role in employment and have a significant role in s...

Ngày tải lên: 01/11/2014, 22:05

... cleaving lamins [39] and membrane blebbing by targeting proteins such as Rho-associated kinase (ROCK1), p- 21 activated kinase (PAK) and gelsolin [40-42] 1. 2 .1. 2 Inhibitors of apoptosis The IAP ... DISC [11 8] and results in the autocatalytic activation of the initiator caspases [11 9] in accordance with the induced proximity model Activated caspase-8/ -10 in...

Ngày tải lên: 11/09/2015, 10:14

... mitochondrial staining (A) Corresponding histogram of the mitochondrial aggregation (B) n =2 90 LY30 and TRAIL treatment engages the mitochondrial apoptotic pathway The release of apoptogenic factors ... treatment alone was unable to induce the activation of any of the caspases investigated and exposure of HeLa cells to LY30 resulted in minimal caspase activat...

Ngày tải lên: 11/09/2015, 10:15