Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... .14 1. 1.2.3 Radiation 18 1. 1.3 Mechanisms for preventing genomic instability 20 1. 1.3 .1 Poly (ADP- ribose) polymerase (PARP -1) 21 1 .1. 3 .1. 1 Role of PARP -1 at the telomeres 24 1. 1.4 ... 1. 1.4 Copper metabolism and disease 27 1. 1.4 .1 PARP -1 and Copper metabolism .29 1. 1.5 1. 2 1. 3 1. 4 Genomic Instability 1. 1 .1. 1 Telomere mediated...
Ngày tải lên: 11/09/2015, 10:18
... prevents excessive SSBs arising during BER or as a result of direct DNA damage Results Cross-linking of BER proteins during repair of damaged DNA Although it has previously been shown that PARP-1 binds ... for binding of XRCC1 and Polb to damaged DNA C Fig Involvement of PARP-1 in BER in human cell extracts (A) A uracil-containing (left panel), or the corresponding con...
Ngày tải lên: 23/03/2014, 13:20
... comparisons (Table 3) PARP-1 modulates microglial trophic factor release Activated microglia can also release, in addition to neurotoxic agents, several cytokines and trophic factors that PARP-1 inhibition ... article as: Kauppinen et al.: Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid b Journal of Neuroinflammation 2011 8:152 Submit your next manuscr...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo y học: "Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line" pptx
... that the heat shock response is negatively modulated by PARP-1 activation in fibroblasts; therefore siRNA mediated PARP-1 inhibition would lead to augmentation of the heat shock response Material ... H, Salzman AL, Szabo C: Peroxynitritemediated DNA strand breakage activates poly- adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macroph...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: " Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line." pptx
... that the heat shock response is negatively modulated by PARP-1 activation in fibroblasts; therefore siRNA mediated PARP-1 inhibition would lead to augmentation of the heat shock response Material ... H, Salzman AL, Szabo C: Peroxynitritemediated DNA strand breakage activates poly- adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macroph...
Ngày tải lên: 11/08/2014, 06:22
Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... fruits PARP involvement during oxidative stress- induced developmental changes in D discoideum To determine the role of PARP in oxidative stressinduced developmental changes, D discoideum cells were ... Rajawat et al PARP in Dictyostelium discoideum development 20 microns Fig Effect of PARP inhibition during oxidative stress- induced developmental changes in...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo y học: "Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury" doc
... Histopathologic findings and acute lung injury (ALI) scores The ventilator-induced lung injury (VILI) group (c) showed typical findings of lung injury, scores such as intra-alveolar exudates, hyaline membrane ... pathophysiology of ventilator-induced lung injury (VILI) are necessary In the VILI model of normal mice lung, injurious mechanical ventilation strategy overact...
Ngày tải lên: 13/08/2014, 11:22
Báo cáo y học: " The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury" ppsx
... Kim HY, Jung KH, Kang EH, Lee SY, Suh IB, Shin C, Shim JJ, In KH, Yoo SH, Kang KH: Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury Crit ... be clinically relevant, is frequently necessary to induce appropriate lung injury Competing interests The authors declare that they have no competing interests References Kim J...
Ngày tải lên: 13/08/2014, 11:23
Tài liệu Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle pptx
... below) within the known members of the PARP family Adjacent to the ANK domain is another protein interaction motif, the sterile alphamodule The C-terminus of tankyrase displays homology to the PARP-1 ... variants of the human PARG have been described, giving rise to PARG isoforms targeted either to the nucleus or to the cytoplasm [47] Overexpression studies revealed th...
Ngày tải lên: 20/02/2014, 01:20
Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... Colosia AD, Donahue JP, Lin YZ, Hawiger J: Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization ... stress-activated protein kinases, also called cJun NH2-terminal kinases (JNKs); and the p38 MAPKs [13] The JNK pathway is of interest because of its capacity to phosphorylat...
Ngày tải lên: 09/08/2014, 07:20
Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... over-expression of p21WAF1 inhibits DNMT1 73 3 .1. 1.7 TSA -mediated induction of p21WAF1 results in inhibition of 76 DNMT1 3 .1. 1.8 TSA -mediated induction of p21WAF1 is independent of p53 85 3 .1. 2 Transcriptional ... between DNMT1 and p21WAF1 in the 63 cell cycle 3 .1. 1 .1 3 .1. 1.2 DNMT1 expression in the cell cycle 63 WAF1 in DNA 67 p21WAF1 68 Tran...
Ngày tải lên: 14/09/2015, 14:13
Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... requires protein translocation to the nucleus Although functional analyses of individual domains have not been addressed, the global context of the domain analyses allows us to draw a more general ... 0.75 are shown Black geometrical shapes are additional domains, as indicated ANOGA, Anopheles gambiae; ASHGOS, Ashbya gossypii; BRARE, Brachydanio rerio; CANDGLA, Candi...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
... and PAI-1 on the rate of thrombin/ PAI-1 complex formation For various combinations of kon and koff for the thrombin/ TM interaction, the concentration of all reactants and intermediates was calculated ... PAI-1 The rate of thrombin inhibition by 1.5 lM PAI-1 was measured in the presence of increasing concentrations (0–800 nM) of solulin Solulin lacks...
Ngày tải lên: 23/03/2014, 17:21
Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx
... that the F-11 cells not only express the rat VRL-1, but also the mouse VRL-1 and that the mouse variant is derived from the F-11 parental cell line N18TG2 This finding is of interest when VRL-1 ... A, B and D of F-11 cells again separated into two bands The slower migrating band always corresponded to the rat brain control, and the faster migr...
Ngày tải lên: 31/03/2014, 07:20