poly adp ribose polymerase critical arbiter of necrosis
Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... (ADP- ribose) polymerase and its cleavage in apoptosis J Biol Chem 273, 33533–33539 Hoger T, de Murcia MJ & de Murcia G (1999) PARP-2, a novel mammalian DNA damage-dependent poly( ADPribose) polymerase ... therapeutic potential of poly( ADP- ribose) polymerase inhibitors Pharmacol Rev 54, 375–429 Palomba L, Sestili P, Cattabeni F, Azzi A & Cantoni O (1996) Prevention of necrosis and activation of apoptosis ... inhibitors of poly( ADPribose) polymerase ⁄ PARP1 and PARP2 identified using a cell-based screen in yeast Cancer Res 61, 4175–4183 Kono Y & Fridovich I (1983) Isolation and characterization of the...
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Báo cáo y học: "Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury" doc
... automodification reaction of poly (ADP- ribose) polymerase J Biol Chem 2001, 276:47664-47670 Hassa PO, Hottiger MO: The functional role of poly( ADPribose )polymerase as novel coactivator of NF-kappaB in ... TS: Poly( ADP- ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB Diabetes 2004, 53:2960-2967 Szabo C, Dawson VL: Role of poly( ADP- ribose) ... dysfunction: the role of poly( ADPribose) polymerase activation Nat Med 2001, 7:108-113 21 Hirano S: Migratory responses of PMN after intraperitoneal and intratracheal administration of lipopolysaccharide...
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Báo cáo y học: " The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury" ppsx
... Suh IB, Shin C, Shim JJ, In KH, Yoo SH, Kang KH: Inflammatory and transcriptional roles of poly (ADP- ribose) polymerase in ventilator-induced lung injury Crit Care 2008, 12:R108 Vaneker M, Halbertsma ... Matthay MA: Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies Chest 2006, 130:19061914 Page of (page number not for citation ... Critical Care Vol 12 No Vaneker et al diseased lungs, normal lungs are relatively insusceptible to the detrimental effects of mechanical ventilation [3] To investigate...
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Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... regulation, transcription and replication 20 1.1.3.1 Poly (ADP- ribose) polymerase (PARP-1) Human poly (ADP- ribose) polymerase (PARP-1), a key player of the BER pathway, is a 113 kDa enzyme encoded ... another poly (ADP- ribose) polymerase that has been shown to have a role at the telomeres is It is a telomere specific member of the PARP family, that interacts with and prevents binding of TRF1 ... Khaw AK, Low GK, Jayapal M, Bhattacharjee RN, Akira S, Balajee AS, Hande MP (2005) Lack of poly (ADP- ribose) polymerase- 1 gene product enhances cellular sensitivity to arsenite Cancer Res.; 65(23):10977-83...
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Báo cáo khoa học: Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts pot
... antibodies raised against poly( ADP- ribose) polymers, and we found that bound proteins undergo substantial poly( ADP- ribosyl)ation Interestingly, the peak of poly( ADP- ribosyl)ation at of incubation using ... significant formation of poly( ADP- ribose) polymers in the absence of PARP-1 We thus conclude that the critical event in an in vitro BER reaction is poly( ADP- ribosyl)ation and dissociation of PARP-1, rather ... Involvement of poly( ADP- ribose) polymerase in base excision repair Biochimie 81, 69–75 D’Amours D, Desnoyers S, D’Silva I & Poirier GG (1999) Poly( ADP- ribosyl)ation reactions in the regulation of nuclear...
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báo cáo hóa học: " Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid b" pot
... Immunostaining for poly( ADP- ribose) , the enzymatic product of PARP-1, showed poly( ADP- ribose) production within 60 minutes of Ab addition, blocked by PJ34 There was no poly( ADP- ribose) signal in ... (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib Arch Neurol 2008, 65:896-905 14 Ha HC, Hester LD, Snyder SH: Poly( ADP- ribose) polymerase- 1 dependence of stress-induced ... Eyupoglu IY, Nitsch R: Regulation of microglial expression of integrins by poly( ADP- ribose) polymerase- 1 Nat Cell Biol 2001, 3:1035-1042 Kauppinen et al Journal of Neuroinflammation 2011, 8:152...
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Báo cáo y học: "Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line" pptx
... Sala A: Poly( ADP- ribose) Polymerase Is a B-MYB Coactivator J Biol Chem 2000, 275:10692-6 Anderson MG, Scoggin KE, Simbulan-Rosenthal CM, Steadman JA: Identification of poly( ADP- ribose) polymerase ... therapeutic potential of poly( ADP- ribose) polymerase inhibitors Pharmacol Rev 2002, 54:375-429 Mota RA, Hernandez-Espinosa D, Galbis-Martinez L, et al: Poly( ADP- ribose) polymerase- 1 inhibition ... Hottiger MO: A role of poly (ADP- ribose) polymerase in NFkappaB transcriptional activation Biol Chem 1999, 380:953-9 38 Kannan P, Yu Y, Wankhade S, Tainsky MA: PolyADP -ribose polymerase is a coactivator...
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Báo cáo y học: " Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line." pptx
... Sala A: Poly( ADP- ribose) Polymerase Is a B-MYB Coactivator J Biol Chem 2000, 275:10692-6 Anderson MG, Scoggin KE, Simbulan-Rosenthal CM, Steadman JA: Identification of poly( ADP- ribose) polymerase ... therapeutic potential of poly( ADP- ribose) polymerase inhibitors Pharmacol Rev 2002, 54:375-429 Mota RA, Hernandez-Espinosa D, Galbis-Martinez L, et al: Poly( ADP- ribose) polymerase- 1 inhibition ... Hottiger MO: A role of poly (ADP- ribose) polymerase in NFkappaB transcriptional activation Biol Chem 1999, 380:953-9 38 Kannan P, Yu Y, Wankhade S, Tainsky MA: PolyADP -ribose polymerase is a coactivator...
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Tài liệu Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle pptx
... size Poly( ADP- ribose) polymerase family, member [PARP-1, ADPRT, ADPRT1, PARP, PPOL, pADPRT-1] Poly( ADP- ribose) polymerase family, member [PARP-2, NAD+ poly( ADP- ribose) polymerase- 2] Poly( ADP- ribose) ... polymerase- 2] Poly( ADP- ribose) polymerase family, member [PARP-3, NAD+ poly( ADP- ribose) polymerase- 3] 1q41-q42 1014 aa (113 kDa) Poly( ADP- ribose) polymerase family, member [PARP4, ADPRTL1, PARPL, PH5P, ... PARP5B, PARP5C, TANK2, TNKL] TCDD-inducible poly( ADP- ribose) polymerase [PARP-7] Poly (ADP- ribose) polymerase family, member 10 [PARP-10] Poly( ADP- ribose) glycohydrolase [PARG] 13q11 143 8p23.1...
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Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt
... Control, 16 Hz eADPR for β-NAD + ADPR + cADPR Ado ADP eADPR for β-NAD + ADPR + cADPR Ado ADP AMP AMP ATP ATP cADPR, 16 Hz cADPR, 16 Hz eADPR for cADPR (1 nM) ADP eADPR for cADPR (1 nM) ADP Ado 25 ... no EFS eADPR for β-NAD + ADPR + cADPR eADPR for β-NAD + ADPR + cADPR Ado ADP eADPR for cADPR (1 nM) eADPR for cADPR (1 nM) ADP ATP Ado AMP 10 AMP cADPR, no EFS cADPR, no EFS 12 25 LU ADP 14 16 ... + ADPR + cADPR Ado ATP AMP β-NAD + ADPR + cADPR ST Ado β-NAD + ADPR + cADPR 100 LU ADP AMP ATP AMP ATP ST Ado ADP ADP Ado ADP AMP ATP ST, TTX ST, TTX β-NAD + ADPR + cADPR Ado ADP AMP β-NAD + ADPR...
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Báo cáo Y học: The DNA-polymerase inhibiting activity of poly(b-L-malic acid) in nuclear extract during the cell cycle of Physarum polycephalum pot
... a and e [13], and DNA polymerase d [14] were consistent with the recovery of > 95% of DNA polymerase a and > 75% of the other DNA polymerases in the extract Standard DNA polymerase activity and ... inhibition of purified DNA polymerase a by poly( b-Lmalate) in the nuclear extract (d) The activity was measured as a function of added amounts of DNA polymerase a in the standard DNA polymerase ... The arrow refers to the equivalence of the added DNA polymerase activity and the inhibitory activity Photoaffinity labeling of DNA polymerases Labeling of DNA polymerases was carried out in a 20-lL...
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Báo cáo y học: "Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model" pot
... partial arterial oxygen pressure; PAR: poly( ADP ribose) ; PARP: poly- ADP ribose polymerase; PCR: polymerase chain reaction; RT-PCR: reverse transcription polymerase chain reaction; Qs/Qt: pulmonary ... role of poly( ADP- ribose) polymerase activation J Pharmacol Exp Ther 2005, 315:812-820 31 McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD: Ischemic nitric oxide and poly (ADP- ribose) polymerase- 1 ... K, Pacher P, Zsengeller Z, Szabo C, Traber DL: Inhibition of poly (ADP- ribose) polymerase attenuates acute lung injury in an ovine model of sepsis Shock 2004, 21:126-133 Murakami K, Bjertnaes LJ,...
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Tài liệu CCNA v2.0 Review Critical Concepts of the 640-802 CCNA Exam ppt
... the "End of Life" milestone End of Life/Last Date of Support After this date, the software release is no longer officially supported by CSE and is removed from CCO Note: Cisco IOS software releases ... Layer address IP v4 Addresses Class Number of Networks First Binary Bits Numerical Range Number of Hosts Number of per Network Network Octets Number of Hosts Octets A 0xxx – 126* 126 16.5 million ... research use only Subnetting Number of networks: 2s – 2, where s = number of bits in the subnet (masked) field Number of hosts per subnet: 2r – 2, where r = number of host (non-masked) bits R + S...
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Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... region of the Fe(III) species, spectra of the Asp40 mutants were essentially similar to that of the wild-type protein Additionally, spin states of the Fe(III), Fe(II) and Fe(II)-CO complexes of Asp40 ... structure of Ec DOS PAS [17] As the structure of the cyanide-bound complex of FixL is similar to that of its oxygen-bound complex [10], a cyanide binding study should facilitate elucidation of the ... component of a denatured form The redox state of haem is related to the PDE activity of Ec DOS, since it is a haem redox-sensing enzyme [2,3] Thus, it is important to determine the redox potentials of...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... analysis of the stoichiometry of the NO-forming reaction disclosed a three-electron process, with decomposition of the N-hydroxyarginine intermediate consuming only 0.5 equivalents of NADPH per mol of ... of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 catalysis came from experiments with metalloporphyrin models [5,6,77] Of ... of the crystal structure of NDO as well as spectroscopic data provide a rationale for the catalytic mechanism of this class of enzymes Naphthalene 1,2dioxygenase is a heterohexamer composed of...
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Tài liệu A CRITICAL EDITION OF YEATS''''S A VISION (1925) pdf
... quarter consists of six phases, or of two sets of three In every case the first phase of each set 25 24 can be described as a manifestation of power, the second of a code or arrangement of powers, ... by means of the AS and Sleeps covered a period of more than seven years (from 24 Oct 1917 to 27 Nov 1923) My count of the number of sessions is less exact than that of the total number of pages, ... arrow Out of the up and down, the wagon wheel Of beauty's cruelty and wisdom's chatter— Out of that raving tide—is drawn betwixt Deformity of body and of mind AHERNE Were not our beds far off I'd...
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Critical evaluation of diagnostic aids for the detection of oral cancer docx
... potential areas of loss of autofluorescence that might be indicative of cytologic and/or molecular changes indicative of premalignancy Nineteen of 20 tumors demonstrated loss of autofluorescence ... al., Critical evaluation of diagnostic aids for the , Oral Oncol (2007), doi:10.1016/j.oraloncology.2007.06.011 ARTICLE IN PRESS Critical evaluation of diagnostic aids for the detection of oral ... al., Critical evaluation of diagnostic aids for the , Oral Oncol (2007), doi:10.1016/j.oraloncology.2007.06.011 ARTICLE IN PRESS Critical evaluation of diagnostic aids for the detection of oral...
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Chart of Accounts: A Critical Element of the Public Financial Management Framework potx
... developing a chart of accounts Introduction1 The chart of accounts (COA) is often considered—in particular, by non-accountants— obscure, if not esoteric, and is often a neglected element of a country’s ... hierarchical structures of groups of classifications of information requirements (see Diagram for an example of a hierarchical structure) Each classification group is often called a segment and ... independently of the date of payment or receipt One of the broad objectives of the reform process was that central government general accounts would reflect the model in the French chart of accounts...
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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
... absence of ester synthase activity In recombinant yeast, the concentration of Adxp, but not of Adrp, controls SCC activity Fig The final levels of accumulated steroids are independent of Datf2 ... levels of expression of various proteins (Adxp, Adrp, CYP11A1) involved in the reaction can also affect the efficiency of cholesterol side chain cleavage Indeed, it is apparent that the expression of ... influence of ergosta-5-eneol availability and electron carrier expression level on the production of pregnenolone and progesterone, and we also determined the localization of the components of the...
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The Critical Period of American History docx
... of "West Florida to the Great Lakes, had passed from the hands of France into those of England at the peace of 1763; and by the Quebec Act of 1774 England had declared the southern boundary of ... the part of the Americans the treaty of Paris was one of the most brilliant triumphs in the whole history of modern diplomacy Had the affair been managed by men of ordinary ability, some of the ... reference to the amount of taxes paid by different parts CHAPTER II 41 of the state The senate of New York, in direct imitation of the House of Lords, was made a supreme court of errors On the other...
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