Regulation of NMDA receptors by serine proteases tissue plasminogen activator (tPA) and plasminogen plasmin

... treatment of ischemic stroke, a pathophysiological condition in which NMDA receptors are implicated 1.7 Tissue- type Plasminogen Activator (tPA) 1.7.1 tPA and stroke Tissue- type plasminogen activator (tPA) ... Thrombin 1.6.3.4 Tissue- type plasminogen activator (tPA) 22 23 23 24 25 26 27 27 27 29 30 30 30 32 1.7 Tissue- type Plasminogen Activator (tP...

Ngày tải lên: 11/09/2015, 10:18

... is likely that the caMEKK1-induced increases in NF-κB and RAR activity are mediated by hyperactivation of p300 Effect of caMEKK1 and ectopic p300 on Sox9 activity (a) Chondroactivity cytes were ... effect of TNF-α on Sox9 activity Finally, the sensitivity of Sox9 to atRA was reduced by caMEKK1 expression Thus, the activity state of p300, the common co-factor a...

Ngày tải lên: 09/08/2014, 10:22

... integrated iron moiety and that NO+ from SNP is responsible for its effect on ferritin synthesis Moreover, acute regulation of ferritin synthesis by NO+ is accomplished by a rapid mobilization of polysome-free ... Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site A study of iron uptake and ferro-oxidase...

Ngày tải lên: 07/03/2014, 12:20

... IRF -3 responsive, including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-specific counterpart [16] The two isoforms ... ArgII expression was inhibited by MG- 132 [20], suggesting indirectly an involvement of NF-jB in ArgII regulation Our study is thus the first direct demonstration...

Ngày tải lên: 07/03/2014, 21:20

... of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) FOREWORD We would like to present to you our study on the Regulation of Interest Rate by the State Bank ... many bankers at the conference have given voice to the regulation on Page of 20 International Finance Regulation of Interest Rate by...

Ngày tải lên: 15/03/2014, 01:20

... role of each telomerase subunit in enzyme activity, we used downregulation of telomerase by inducing differentiation of HL-60 cells, and up -regulation of telomerase by stimulating proliferation of ... inhibition of TEP1 function by high concentrations of antisense oligonucleotides, telomerase activity was dramatically diminished Alternatively, hTR and hTERT ma...

Ngày tải lên: 17/03/2014, 23:20

... (GDI) that bind to the GDP bound form of Gia and inhibit the exchange of GDP-bound for GTP-bound Ga [73–75] These signaling partners of G proteins might also be involved in the regulation of microtubule ... MT with GTP cap G γ No Effect GDPTubulin Effectors Promotion of MT assembly by G γ GTP-Tubulin γ-Tub Fig Model for the regulation of microtubule (MT) assembl...

Ngày tải lên: 30/03/2014, 10:20

... shared by Sec14p and Sfh proteins assumes functional significance because some of the Sec14 homologues (namely Sfh2 and Sfh4), when overexpressed, complemented the sec14-related growth and secretory ... could substitute for Sec14p in its role as a regulator of phospholipid biosynthesis Under conditions where Sec14p is nonfunctional and the CDP-choline pathway for Pt...

Ngày tải lên: 30/03/2014, 15:20

... suggest that proteolytic processing is a general mechanism for the negative regulation of STAT protein function (Fig 4) Truncated forms of Stat3 , Stat5 a, Stat5 b and Stat6 , generated by the proteolytic ... cells Proteolytic regulation of Stat5 and Stat3 in mature human neutrophils Stat3 and Stat5 isoforms have been identified in differentiated human perip...

Ngày tải lên: 30/03/2014, 15:20

... of leptin and progesterone on FAAH activity and expression (A) Effect of leptin on the activity of FAAH in human U937 and CHP100 cells and on the protein content and the mRNA of FAAH in U937 cells ... triggered by leptin or progesterone in immune cells are missing in neuronal cells On the other hand, it is also possible that silencers of FA...

Ngày tải lên: 30/03/2014, 15:20

... a splice variant of As -rel1 The nucleotide sequence encoding RHD of As -rel1 is completely identical with that of As -rel2 [15], indicating the possibility that As -rel1 and As -rel2 are splice variants ... As -rel1 and As -rel2 are splice variants (A) Schematic representation of the structures of the As -rel genome and mRNAs of As -rel1 and As -rel2 (B) Genome sequence...

Ngày tải lên: 30/03/2014, 20:20

... recruitment to the FeLV-945 LTR might interfere with CBP availability and thereby alter the regulation of CBP- responsive genes Such alteration might then contribute to altered hematopoiesis and consequent ... regulated by CBP in a manner dependent on the presence of the 21-bp triplication (Figure 7) These results indicated that the interaction between c-My...

Ngày tải lên: 18/06/2014, 22:20

... recruitment to the FeLV-945 LTR might interfere with CBP availability and thereby alter the regulation of CBP- responsive genes Such alteration might then contribute to altered hematopoiesis and consequent ... regulated by CBP in a manner dependent on the presence of the 21-bp triplication (Figure 7) These results indicated that the interaction between c-My...

Ngày tải lên: 20/06/2014, 04:20

... http://www.josr-online.com/content/5/1/37 the detailed mechanism of the temporal and spatial regulation of Osx for bone formation and homeostatic regulation of skeletal system The need to develop novel drugs that stimulate bone formation ... as: Zhang, Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Os...

Ngày tải lên: 20/06/2014, 04:20