Modulation of west nile virus capsid protein and viral RNA interaction through phosphorylation 5

... (19 85) Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins Virology 1 45, ... localisation of C protein could indirectly prevent premature C protein and RNA association, although direct regulation of C protein and RNA interaction wa...

Ngày tải lên: 11/09/2015, 10:05

... West Nile virus capsid protein attenuates its interaction with viral RNA 14 th International Congress of Virology, Istanbul Cheong, Y.K and Ng M.L (2008) West Nile Virus capsid protein and RNA interaction ... Introduction………………………………………………….……… .1 1.2 West Nile virus epidemiology………………… …………….………… 1. 3 Virus morphology…………………………………………….………….4 1....

Ngày tải lên: 11/09/2015, 10:04

... A-sense RNA UTR+C R RNA 1F RNA 1R RNA 2F RNA 2R RNA 3F RNA 3R RNA 4F RNA 4R RNA 5F RNA 5R RNA 6F RNA 6R RNA 7F RNA 7R RNA 8F RNA 8R RNA 9F RNA 9R RNA 10F RNA 10R RNA 11F RNA 11R RNA 12F RNA 12R A-sense ... Appendix 3B | Materials and methods 32 Table 2- 3 List of the names of primers used and its purpose No 10 11 12 13 14 15 16 17 1...

Ngày tải lên: 11/09/2015, 10:04

... most often Fragment 13 and 14 are anti-sense fragments of Fragments and 12 This suggests that C protein binding sites on the WNV RNA are found in the regions of - 2 934 and 96 13 - 11057 of the ... of myc-C protein and synthesized viral RNA in BHK cells (A) Visualization of myc-C protein and transfected viral RNA in BHK cells with fluorescence microscopy...

Ngày tải lên: 11/09/2015, 10:05

... histidine-tagged C (His-C) protein (Lane 3) |Results 105 5.3 Phosphorylation of the West Nile virus (WNV) capsid (C) protein 5.3.1 West Nile virus (WNV) capsid (C) protein is a phosphoprotein In order ... transfected 293FT 48 hr 55 kDa 43 kDa 34 kDa 26 kDa 17 kDa 55 kDa 43 kDa 34 kDa 26 kDa 17 kDa 22 125 5.5 Phosphorylation of West Nile virus (WNV) ca...

Ngày tải lên: 11/09/2015, 10:05

... injections of the vaccine completely protected mice from a lethal WNV challenge, even when given in the absence of any adjuvant The relatively low production costs of the DIII-C-AP205 vaccine, ... uses thereof 2007 doi: 10.1186/1743-422X-7-146 Cite this article as: Spohn et al., A VLP-based vaccine targeting domain III of the West Nile virus E pro...

Ngày tải lên: 12/08/2014, 04:20

... study was limited in its scope, the results indicate that WNV strain IS-98-ST1 is suitable as viral model for West Nile encephalitis in the Old World The Israeli strain IS-98-ST1 that caused the ... the fact that an Israeli WNV strain was introduced in New York City in 1999 [4] The murine model of WNV-associated encephalitis has been wid...

Ngày tải lên: 18/06/2014, 22:20

... Ben Yahia S, Ladjimi A, et al Chorioretinal involvement in patients with West Nile virus infection Ophthalmology 2004;111:2065-70 Garg S, Jampol LM Systemic and intraocular manifestations of West ... routine evaluation of patients with clinically suspected WNV infection References Hayes EB, Gubler DJ West Nile virus: epidemiology and clinical features of an emerging epide...

Ngày tải lên: 08/08/2014, 17:20

... root inflammation of the cauda equina, thus a diagnosis of West Nile virus acute flaccid paralysis was made The patient was discharged home after 10 days in the hospital Following discharge she ... forms of West Nile virus neuroinvasive disease, most cases of acute flaccid paralysis occur in healthy, non-elderly individuals [9,17,18], although advanced age may be...

Ngày tải lên: 10/08/2014, 23:20

... ultra-structural studies Results and Discussion West Nile (Sarafend) virus-induced changes in infected cells at late stage infection At the late stages of West Nile (Sarafend) virus infection in Vero ... Journal of Nanobiotechnology 2004, 2:6 http://www.jnanobiotechnology.com/content/2/1/6 Figure height scan of West Nile virus-infected Vero cells at 24 h p.i (a) AFM1 (a)...

Ngày tải lên: 11/08/2014, 00:22

... as: Mainali et al.: The natural history of West Nile virus infection presenting with West Nile virus meningoencephalitis in a man with a prolonged illness: a case report Journal of Medical Case ... progression of WNND Case presentation A 56-year-old African-American man with a history of hypertension and chronic hepatitis C vi...

Ngày tải lên: 11/08/2014, 00:23

... residental and migratory birds [23] In conclusion, this first serological survey of West Nile virus in Gabonese human populations shows widespread circulation of this virus Further investigations are ... Transmission dynamics and changing epidemiology of West Nile virus Anim Health Res Rev 2008, 9:71-86 Mathiot CC, Georges AJ, Deubel V: Comparative analysis of...

Ngày tải lên: 12/08/2014, 04:20

... similar to a strain isolated during an outbreak in Israel during 1998 [4] and was considered to be the dominant variant circulating through North America until 2002 During that year, a variant arose ... 5'-CCTTGGAGCAGTGCTGGAAGTA-3' (1636–1657) 5'-CGGCTCATACATAAGCGCGAT-3' (5085–5105) 5'-TTCCACAAAGGTCGAGCTAGG-3' (5514–5534) 5'-CCATCTGCAGTGACAGCAGCTA-3' (5950–5971) 5'-TGTTCCCTTCAGCTGCAACTT...

Ngày tải lên: 12/08/2014, 04:21

... similar to a strain isolated during an outbreak in Israel during 1998 [4] and was considered to be the dominant variant circulating through North America until 2002 During that year, a variant arose ... 5'-CCTTGGAGCAGTGCTGGAAGTA-3' (1636–1657) 5'-CGGCTCATACATAAGCGCGAT-3' (5085–5105) 5'-TTCCACAAAGGTCGAGCTAGG-3' (5514–5534) 5'-CCATCTGCAGTGACAGCAGCTA-3' (5950–5971) 5'-TGTTCCCTTCAGCTGCAACTT...

Ngày tải lên: 12/08/2014, 04:22