Investigation of complement protein c1q implications for its protective roles against systemic lupus erythematosus

... normal population of DCs in healthy individuals 1.3 Systemic Lupus Erythematosus (SLE) 1.3.1 General overview Systemic lupus erythematosus (SLE) or lupus is a multi-factorial systemic autoimmune ... 1.4.2 1.4.2.1 The complement pathways 15 1.4.2.2 C1q in complement- mediated inflammation and defense against pathogens 15 1.4.3 Other roles of C1q 18 C1q product...

Ngày tải lên: 11/09/2015, 10:05

... ribosomal P proteins in systemic lupus erythematosus Am J Med 1991, 90:54-62 Isshi K, Hirohata S: Association of anti-ribosomal P protein antibodies with neuropsychiatric systemic lupus erythematosus ... sequence of ribosomal P protein (anti-PC22) and those to the ribosomal P protein epitopes other than the C-terminal 22-amino acid sequence (anti-PEX.C22) in...

Ngày tải lên: 09/08/2014, 10:20

... are the C-type lectin receptors (CTLRs) The CTLRs comprise a family of evolutionarily conserved proteins containing one or more C-type lectin domains, and may bind carbohydrate moieties in a calcium-dependent ... proinflammatory cytokines, and increased ability to promote increased proliferation and activation of allogeneic control T cells [21] In the present study,...

Ngày tải lên: 09/08/2014, 13:22

... of TGFb and RA in SLE patients suggests that at least the latter mechanism is defective, either because there are too many memory T cells or they are refractory to RA inhibition Interestingly, ... population that is expanded in SLE patients corresponds to either activated T cells or to “ex-Treg” that have lost their suppressive activity Further analyses, including the...

Ngày tải lên: 12/08/2014, 17:22

... noninvasive evaluation of coronary atherosclerosis and myocardial perfusion abnormalities, and enables the assessment of statin influence on coronary artery structural changes and heart function ... of Table Persistent and exercise-induced myocardial perfusion defects in SLE patients from placebo group and atorvastatin group at randomization and after one...

Ngày tải lên: 12/08/2014, 17:22

... interaction of ATP with hGK, with possible implications for the positive kinetic cooperativity with respect to Glc Results ATP binding at active site of human glucokinase (WT) hGK and WT GST–hGK enzymes ... steady-state kinetic analyses are also compatible with conformational control of GK catalytic activity by the binding of (Mg )ATP, with...

Ngày tải lên: 06/03/2014, 00:20

... E.T., and Holmes, J., 2008, Investigation of organic chemicals potentially responsible for mortality and intersex in fish of the North Fork of the Shenandoah River, Virginia, during spring of 2007: ... liter (pg/L) Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the...

Ngày tải lên: 14/02/2014, 08:20

... (2007) Effect of hypoxia on gene expression of bone marrowderived mesenchymal stem cells and mononuclear cells Stem Cells 25, 1166–1177 Li L, Zhang S, Zhang Y, Yu B, Xu Y & Guan Z (2009) Paracrine ... the secretion of IL-1b and TNF-a, suggesting that the roles of these factors in the paracrine effects of MSCs are negligible However, hypoxia ⁄ SD also enhanc...

Ngày tải lên: 18/02/2014, 04:20

... China’s Holdings of U.S Securities: Implications for the U.S Economy Table Top 10 Foreign Holders of U.S.Treasury Securities as of September 2012 Total Foreign Holdings ($ billions) Country Holdings ... Service 16 China’s Holdings of U.S Securities: Implications for the U.S Economy holdings of U.S assets The initial effect could be a sudden and la...

Ngày tải lên: 20/02/2014, 20:20

... Both transitions to latent and substrate forms were strongly but differently influenced by the amino-acid composition of the shutter region Surprisingly, we found that substitution of Lys335 to ... investigate the importance of the shutter region for the unique types of RCL insertion in PAI-1, we have now undertaken a number of substitutions in...

Ngày tải lên: 22/02/2014, 07:20

... Institutional and Structural Problems of China's Foreign Exchange and Implications for the New Exchange Rate Regime', China: an Internatinal Journal, Vol 4, No 1, p 26 30 NOTES The data for NEER and REER ... exchange rate policy and the mechanisms which have been developed to support these preferences Section draws the main implications of the conduct of exchang...

Ngày tải lên: 07/03/2014, 18:20

... GLUT8 in testis, the nature of its sorting, and the interaction of its Nterminal dileucine motif with the various AP subunits The [DE]XXXL[LI] signal of GLUT8 has been shown to bind to the b2-adaptin ... some of these discrepancies in order to (a) identify the subcellular localization of GLUT8 in testis, (b) elucidate the role of APs in...

Ngày tải lên: 16/03/2014, 02:20

... interact with a ubiquitin precursor UbC1 through their first UBA domain, resulting in the hydrolysis of UbC1 by an unidentified ubiquitin C-terminal hydrolase (UCH) The recruitment of UbC1 to the UCH appears ... with UbC1 before its hydrolysis in yeast cells; (b) NUB1 might directly interact with ubiquitin monomer units before or after the hydrolysis of...

Ngày tải lên: 23/03/2014, 12:20

... writing of the manuscript FMM participated in designing the study and the writing of the manuscript DFS participated in designing the study, coordinating the study and the writing of the manuscript ... thank the staff of the NIH, Clinical Center, Dowling Clinic, Department of Transfusion Medicine, Clinical Center, NIH for collecting the cells and the Cell...

Ngày tải lên: 18/06/2014, 16:20