Phospholipid signaling pathways triggered by the antigen receptors in t lymphocytes
... responses triggered by the activation of the TCR, it is therefore of crucial importance to understand the multi-step signaling cascade triggered by the TCR activation During the last few years it has ... degradation of the pseudosubstrate resulting in release of autoinhibitory interactions between the regulatory and kinase domains of the enzyme The activation of...
Ngày tải lên: 11/09/2015, 09:05
... I 1. 1 INTRODUCTION 1. 1 .1 Complement proteins and nomenclature 1. 1.2 Activation of the complement cascade 1. 1.2 .1 The classical pathway 1. 1.2.2 The alternative pathway 1. 1.2.3 The mannan-binding ... ligand C5a 11 1. 1.5.3 Complement 5a receptor (C5aR) 13 1. 1.5.4 Role of C5a in diseases 1. 2 The complement system 16 Important downstream events triggered...
Ngày tải lên: 14/09/2015, 21:55
... in the case of hOR1D2, only in two out of four experiments Other olfactory receptors, such as mOR167-4, mOR199 -1, M 71, M72 and mOR2 41- 1 B C D E Fig The C-terminus of OR2AG1 interacts with MUPP1 ... (19 99) The organization of INAD -signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling Cell Ca...
Ngày tải lên: 18/02/2014, 13:20
Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
... between the EGFR and the androgen receptor in prostate carcinoma cells [50] The interplay between decorin and the EGFR is further underscored by osteosarcoma cells which escape the decorin-suppressing ... enhancing its binding to chordin [71] The latter, in turn, leads to BMP-4 inactivation by the chordin– twisted gastrulation complex [71] Lumican signaling in ce...
Ngày tải lên: 15/03/2014, 23:20
Báo cáo y học: "Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients" docx
... pro-inflammatory cytokines by cells of the innate immune system could also favour the recruitment of lymphocytes into the lamina propria and epithelium, contributing to full expression of the ... regulatory role for the former strain IL-10 plays an important role in regulating the inflammatory cascade in the intestinal mucosa by its action on antigen-presenting...
Ngày tải lên: 11/08/2014, 08:22
Tài liệu Báo cáo khoa học: Shaped by the environment – adaptation in plants Meeting report based on the presentations at the FEBS Workshop ‘Adaptation Potential in Plants’ 2009 (Vienna, Austria) pdf
... result of global climate change The presentations at the FEBS Workshop Adaptation Potential in Plants covered a broad range of topics concerning adaptation, including the control of genomic variability, ... variation is important in the adaptation of Arabidopsis to different winter climates [32] To determine whether the variation in vernalization response is an...
Ngày tải lên: 18/02/2014, 11:20
Báo cáo khoa học: Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells doc
... the early < /b> signaling < /b> events < /b> induced < /b> by < /b> SEB in human PBMCs to determine the pathway inter-connectors We hypothesized that Effects of < /b> SEB on < /b> human PBMCs such signaling < /b> inter-connectors can be effectively ... partial inhibitory effect < /b> on < /b> JNK activation (Table 1) MAPK inhibitor < /b> PD98059 had a negligible effect < /b>...
Ngày tải lên: 30/03/2014, 04:20
accomplishment of largescaled inspection by the government inspectorate in the implementation of social policies
... inspection by the Government Inspectorate in the implementation of social policies Determining the content of inspection Approving the content of inspection by the leaders of the Government Inspectorate ... large-scaled inspection by the Government Inspectorate in the implementation of social policies 3.2 Scope of research...
Ngày tải lên: 19/07/2014, 08:52
Báo cáo y học: "Ethnomedical survey of plants used by the Orang Asli in Kampung Bawong, Perak, West Malaysia" docx
... which are used in Kampung Bawong (Table 1) Most of these species grow in the wild naturally and their medicinal properties are crucial in traditional medicine of the Orang Asli Majority of the species ... time by the ethnic group Conclusions This current ethnomedical field survey carried out among the Orang Asli living in the Kampung Bawong region...
Ngày tải lên: 10/08/2014, 09:20
Báo cáo y học: " Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes" pptx
... characterize their phenotype after cytokine stimulation Cells were first incubated for 30 minutes with FCS before staining to avoid non specific fixation of the antibodies To assess the purity of ... of these molecules was analyzed first on resting cells and then on cytokine-activated cells To mimic inflammation, we chose to analyze the effect on the AECII phenotype of...
Ngày tải lên: 12/08/2014, 13:22
Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... activation was Src- and Shc-dependent and resulted in enhanced expression of the uPA gene and, to a lesser extent, of the MMP-9 gene (data not shown) Disruption of cell–cell adhesion by calcium chelation ... leading to the uPA gene However, the nature of these signaling events has remained largely unknown Because both disruption of E-cadherin- depen...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt
... suggest that in the resting state of the transporter the nonhomologous C-terminal segments of TAP1 and TAP2, and not the core NBDs, determine the distinct nucleotide binding properties of the two polypeptides ... the b11strands (Fig 1A) of TAP1 and TAP2 are directly involved in the distinct nucleotide binding and function of the N...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... that the inhibitory effect of NAMI-A on c-myc gene expression may have occurred by suppressing ERK1/2 activation and activity elicited by PMA-generated signals Unlike the ras gene family, mutations ... relationship between the inhibitory effect of NAMI-A on ERK1/2 activation and NAMI-A- induced down regulation of c-myc gene expression NAMI-A inhibits...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... for the endogenous kinase in the association with Grx4p, whereas a similar amount of the S25 8A mutant (lane 3) failed to bind Grx4p, as shown by a signal comparable to the background level (lane ... phosphorylation states of Sch9p, as already demonstrated [21] Next, we investigated whether Bud32p is a substrate of Sch9p The HA-tagged Sch9p was immunoprecipi...
Ngày tải lên: 07/03/2014, 04:20