Elucidating the genetic basis of severe obesity learning from the experiments of nature

... ELUCIDATING THE GENETIC BASIS OF SEVERE OBESITY: LEARNING FROM THE EXPERIMENTS OF NATURE DR LEE YUNG SENG MBBS, MMED (PAED MED), MRCP (UK), MRCPCH, FAMS A THESIS SUBMITTED FOR THE DEGREE OF ... supported the role of genes in the pathogenesis of human obesity However, obesity has a wide phenotypic variability, ranging from the mildly overweight to...

Ngày tải lên: 11/09/2015, 09:02

... reflect the effects of large numbers of genetic variants of relatively small effect and, therefore, that genetic dissection of such traits will require investigation of samples of considerable size ... important form of corroboration of the role of a given gene in contributing to complex behavioral traits Demonstrations of the importance of pleiotropy in the genet...

Ngày tải lên: 06/08/2014, 19:21

... with A and B genome [3] Several studies aimed at identifying the wild diploid ancestors of A hypogaea The wild species A duranensis and A ipaënsis appeared to be the best candidates for the A and ... diploid AA and A ipaënsis KG30076 diploid BB), a tetraploid AABB amphidiploid (A ipaënsis × A duranensis)4X, hereafter called AiAd and a cultivated tetraploid A...

Ngày tải lên: 12/08/2014, 03:21

... loci in the Chinese, Malay and Asian-Indians in Singapore Presented at the inaugural Asian Association for the Study of Diabetes in Osaka, Japan (20 09) TABLE OF CONTENTS 10 11 12 13 14 15 16 17 Acknowledgements ... Malay and Asian-Indian populations in Singapore We also examined their associations with traits that appear to be involved in the pathogenesis of t...

Ngày tải lên: 14/09/2015, 08:48

... 100-fold and the lifespan of the complex by 10-fold, as judged by koff The physiological chaperone cycle probably consists of the rapid binding of the N-terminus of the partner, regardless of whether ... NaCl The values presented are the average of at least three independent experiments Complex NarJ NarG( 1–28) NarJT NarG( 1–28) NarJ NarG( 1–15) NarJT NarG(...

Ngày tải lên: 16/02/2014, 14:20

... questions within the scope of the Christian Faith The function of the age of the Councils was the formulation and definition of Christian dogma upon the admitted basis of the revelation of Jesus Christ ... The Basis of Early Christian Theism, by inconsistent hyphenation of the word stand-point has been retained Greek has been transliterated and...

Ngày tải lên: 21/02/2014, 08:20

... or NMR structural analyses and the construction of artificial libraries allow constructive selection and functionalization not only of antibody fragments, but also of small, nonantibody proteins ... demonstrating the utility of the grafting of functional peptides with randomized edge sequences for optimizing the orientation of the grafted peptide on a scaffold p...

Ngày tải lên: 06/03/2014, 11:20

... hypophosphatasia, (b) infantile hypophosphatasia, (c) childhood hypophosphatasia, (d) adult hypophosphatasia and (e) odonto hypophosphatasia [1–4] Perinatal and infantile forms of hypophosphatasia are ... Molecular basis of perinatal form of hypophosphatasia N Numa et al Hypophosphatasia is caused by various mutations of the tissue-nonspecific alkaline pho...

Ngày tải lên: 07/03/2014, 05:20

... rows The first step of the evaluation process is to fill in the cells with the semantic roles the given suffix can code in the context of the verb We consider the clusters correct, if the corresponding ... source in the environment of movement verbs Both cases having the same semantic role, the decision between them is determined by the semantics of the corr...

Ngày tải lên: 08/03/2014, 03:20

... data, the Penn Treebank (Marcus et al., 1993), so as to abstract from a particular POS tagger and to provide an upper bound In another experiment, parsing is done on the basis of the words alone ... POS as input for the combined chunking and functiontagging task depends on the amount of training data available The absolute performance of words depends on the...

Ngày tải lên: 08/03/2014, 07:20

... discussion The median ranks of the strong associations for all models are plotted in Figure The means show the same pattern, but give a less clear indication of the number of associations that ... from corpus limitations rather than from the model itself Conclusions and future research In this paper, we explored three types of basic approaches to the prediction...

Ngày tải lên: 08/03/2014, 21:20

... examine the effect of the APOH promoter SNPs on plasma b2GPI levels; and (d) to determine the cross-species conservation of the APOH promoter sequence To identify regions of the APOH promoter that ... quantitative change at the protein level Whether the APOH promoter SNPs ()643T>C and )1219G>A) could influence the promoter activity by either the former or...

Ngày tải lên: 15/03/2014, 10:20

... and likeness; and let him have dominion over the fishes of the sea, and the fowls of the air, and the beasts, and the whole earth, and every creeping creature that creepeth upon the earth.” And ... understand the laws of moral nature the principles of Ethics—more thoroughly than most of their predecessors did, and they have modified their treatme...

Ngày tải lên: 15/03/2014, 13:20