Elucidating the genetic basis of severe obesity learning from the experiments of nature
Elucidating the genetic basis of severe obesity learning from the experiments of nature
... ELUCIDATING THE GENETIC BASIS OF SEVERE OBESITY: LEARNING FROM THE EXPERIMENTS OF NATURE DR LEE YUNG SENG MBBS, MMED (PAED MED), MRCP (UK), MRCPCH, FAMS A THESIS SUBMITTED FOR THE DEGREE OF ... supported the role of genes in the pathogenesis of human obesity However, obesity has a wide phenotypic variability, ranging from the mildly overweight to the morbidly obese, as well as the spectrum of ... account of our contribution to this field of obesity research, not only in the discovery of novel MC4R mutations causing monogenic human obesity, but also the role of genetic variants of POMC...
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Báo cáo sinh học: "The complex genetic basis of simple behavio" ppt
... reflect the effects of large numbers of genetic variants of relatively small effect and, therefore, that genetic dissection of such traits will require investigation of samples of considerable size ... important form of corroboration of the role of a given gene in contributing to complex behavioral traits Demonstrations of the importance of pleiotropy in the genetic regulation of behavioral ... that a universal feature of complex behavior may be the contribution of numerous genetic variants of small effect may influence experimental design in human genetic studies of behavioral traits Furthermore,...
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báo cáo khoa học: " Genetic mapping of wild introgressions into cultivated peanut: a way toward enlarging the genetic basis of a recent allotetraploid" docx
... with A and B genome [3] Several studies aimed at identifying the wild diploid ancestors of A hypogaea The wild species A duranensis and A ipaënsis appeared to be the best candidates for the A and ... diploid AA and A ipaënsis KG30076 diploid BB), a tetraploid AABB amphidiploid (A ipaënsis × A duranensis)4X, hereafter called AiAd and a cultivated tetraploid AABB variety (Fleur 11), was used ... the genome-wide analysis of the transmission of chromatin between wild and cultivated species of the genus Arachis However, the wild parents used to create the amphidiploid (A batizocoi, A cardenasii...
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The genetic basis of type 2 diabetes in a multi ethnic population in singapore
... loci in the Chinese, Malay and Asian-Indians in Singapore Presented at the inaugural Asian Association for the Study of Diabetes in Osaka, Japan (20 09) TABLE OF CONTENTS 10 11 12 13 14 15 16 17 Acknowledgements ... Malay and Asian-Indian populations in Singapore We also examined their associations with traits that appear to be involved in the pathogenesis of type diabetes; namely obesity, insulin resistance ... be of interest to examine this in our multi- ethnic population 23 AIMS The overall objective of this thesis is to examine the genetic basis of type diabetes in the Chinese, Malay and Asian-Indian...
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Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
... 100-fold and the lifespan of the complex by 10-fold, as judged by koff The physiological chaperone cycle probably consists of the rapid binding of the N-terminus of the partner, regardless of whether ... NaCl The values presented are the average of at least three independent experiments Complex NarJ NarG( 1–28) NarJT NarG( 1–28) NarJ NarG( 1–15) NarJT NarG( 1–15) NarJT NarG( 1–15) (At pH 8.0) NarJ NarG( 1–15) ... NarH and NarI subunits [4] Here we addressed the question of the structure adopted by the N-terminus of NarG during the recognition process At first, we synthesized two peptides [NarG( 1–15) and NarG( 1–28)]...
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Tài liệu The Basis of Early Christian Theism ppt
... questions within the scope of the Christian Faith The function of the age of the Councils was the formulation and definition of Christian dogma upon the admitted basis of the revelation of Jesus Christ ... The Basis of Early Christian Theism, by inconsistent hyphenation of the word stand-point has been retained Greek has been transliterated and placed inside {}.] THE BASIS OF EARLY CHRISTIAN THEISM ... because of their rejection of the gods of Greece and Rome; of immorality, because of the secrecy and mystery of their meetings, and cannibalism, because of their doctrine of the partaking of the...
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Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
... or NMR structural analyses and the construction of artificial libraries allow constructive selection and functionalization not only of antibody fragments, but also of small, nonantibody proteins ... demonstrating the utility of the grafting of functional peptides with randomized edge sequences for optimizing the orientation of the grafted peptide on a scaffold protein In addition, when the ... library constructed from only Tyr, Ser, Asp, and Ala, and X-ray structural analysis demonstrated the importance of Tyr residues [38] The construction of more restricted libraries from only Tyr and...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
... hypophosphatasia, (b) infantile hypophosphatasia, (c) childhood hypophosphatasia, (d) adult hypophosphatasia and (e) odonto hypophosphatasia [1–4] Perinatal and infantile forms of hypophosphatasia are ... Molecular basis of perinatal form of hypophosphatasia N Numa et al Hypophosphatasia is caused by various mutations of the tissue-nonspecific alkaline phosphatase (TNSALP) gene (EC ... Replacement of valine at position of 406 with alanine was reported in a patient diagnosed with perinatal hypophosphatasia who was a compound heterozygote for this mutation and A9 9T [20] The valine...
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Báo cáo khoa học: "Clustering Hungarian Verbs on the Basis of Complementation Patterns" pot
... rows The first step of the evaluation process is to fill in the cells with the semantic roles the given suffix can code in the context of the verb We consider the clusters correct, if the corresponding ... source in the environment of movement verbs Both cases having the same semantic role, the decision between them is determined by the semantics of the corresponding NP These cases code an other semantic ... contain many of the most frequent verbs and yet are characterized by strong inter-cluster coherence due to the method used The three clusters absorbed one third of the 71 categorized verbs The...
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Báo cáo khoa học: "Shallow parsing on the basis of words only: A case study" pptx
... data, the Penn Treebank (Marcus et al., 1993), so as to abstract from a particular POS tagger and to provide an upper bound In another experiment, parsing is done on the basis of the words alone ... POS as input for the combined chunking and functiontagging task depends on the amount of training data available The absolute performance of words depends on the treatment of rare words The additional ... performance of a plain words input representation with that of a gold-standard POS one In the second we introduce a variant of the word-based task that deals with low-frequency words The last paragraph...
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Báo cáo khoa học: "Predicting Strong Associations on the Basis of Corpus Data" pdf
... discussion The median ranks of the strong associations for all models are plotted in Figure The means show the same pattern, but give a less clear indication of the number of associations that ... from corpus limitations rather than from the model itself Conclusions and future research In this paper, we explored three types of basic approaches to the prediction of strong associations to ... classification of asymmetric associations They show the chi-square metric to be a robust classifier of associations as either symmetric or asymmetric, while a measure based on conditional probabilities...
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Báo cáo khoa học: Functional and genetic characterization of the promoter region of apolipoprotein H (b2-glycoprotein I) ppt
... examine the effect of the APOH promoter SNPs on plasma b2GPI levels; and (d) to determine the cross-species conservation of the APOH promoter sequence To identify regions of the APOH promoter that ... quantitative change at the protein level Whether the APOH promoter SNPs ()643T>C and )1219G>A) could influence the promoter activity by either the former or latter methods is beyond the scope of in vitro ... highlighted as evolutionary conserved regions (pink rectangles at the top of the graphs) The horizontal axis represents positions in the base genome (human) and the vertical axis represents the...
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MORAL PRINCIPLES AND MEDICAL PRACTICE, THE BASIS OF MEDICAL JURISPRUDENC potx
... and likeness; and let him have dominion over the fishes of the sea, and the fowls of the air, and the beasts, and the whole earth, and every creeping creature that creepeth upon the earth.” And ... understand the laws of moral nature the principles of Ethics—more thoroughly than most of their predecessors did, and they have modified their treatment so as to conform it to these rules of morality ... course of lectures the science of MEDICAL JURISPRUDENCE It is the characteristic of science to trace results to their causes The science of Jurisprudence investigates the causes or principles of...
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Từ khóa: genetic basis of coeliac diseasegenetic basis of celiac diseaseunderstanding the molecular basis of celiac disease what genetic studies revealthe basis of bills of exchangebiological basis of geneticthe basis of corpus databiological basis of genetic engineeringgenetic diseases of the eye pdfthe chemical basis of life worksheet answersdiscuss briefly the nature origin and the basis of public international lawnature origin and the basis of public international lawthe chemical basis of life chapter 2 test your knowledge answersthe chemical basis of life chapter 2 study guide answersthe chemical basis of life chapter 2 quizthe chemical basis of life chapter 2 study guideBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ