edox regulation of akt phosphorylation in PTEN mouse embryonic fibroblasts

... maintenance of the hyperphosphorylated Akt observed in MEFPTEN-/- cells In the current project, the PTEN- independent pathways involved in the regulation of Akt phosphorylation by O2.- in MEFPTEN-/- ... of intracellular level of O2.- in MEFPTEN-/- cells results in a decrease in the phosphorylation level of the otherwise hyperphosphorylated Akt kinase In...

Ngày tải lên: 10/09/2015, 15:52

... exchanger- 1 (NHE1) 1. 1 .1 NHE1 isoforms and NHE1 structure 1. 1.2 Regulation of NHE1 1. 1.3 Physiological function of NHE1 1. 1.4 Role of NHE1 in cancer progression 11 ... formation of Hsp90/Akt/NHE1 complex in MCF10AT1 12 4 3.3.3 Akt regulates NHE1 protein expression in MCF10CA1a 13 1 3.3.4 NHE1 interacts with Akt in MCF10CA1a and not MCF10CA1h 13 4 3.3.5...

Ngày tải lên: 10/09/2015, 09:29

... N-terminal domain of HRI and in an insert region in the protein kinase domain of HRI (63) Heme, in the presence of iron, binds to α and β globin chains in ratio of 1:2:2, respectively In response to iron ... Palam REGULATION OF CHOP TRANSLATION IN RESPONE TO eIF2 PHOSPHORYLATION AND ITS ROLE IN CELL FATE In response to different en...

Ngày tải lên: 24/08/2014, 12:32

... and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... start sites initiating biosynthesis of the 88, 77, 74 and 63 kDa iPLA2c isoforms Instead, based on current information about iPLA2c and its splici...

Ngày tải lên: 19/02/2014, 16:20

... restriction to Lck accessing certain tyrosine residues of the protein chain Our studies have determined the efficiency of phosphorylation of each of the six f ITAM tyrosines by PTK Lck, from which ... vitro phosphorylation by Lck, confirmed tyrosine 1N to be the first phosphorylated Differences arising in the order of phosphorylation of the sub...

Ngày tải lên: 08/03/2014, 02:20

... Three -modular kinetic analysis of effects of Cd2+ and Cu2+ ions on oxidative phosphorylation Bimodulular kinetic analysis of the effects of Cd2+ and Cu2+ ions on oxidative phosphorylation To determine ... Effect of Cd2+ and Cu2+ ions on the kinetics of the CoQ-reducing and CoQoxidizing modules Effect of Cd2+ on the kinetics of the CoQ-ox...

Ngày tải lên: 16/03/2014, 02:20

... (forward, 5¢-AAG GCT TAC CAC GAG CAG CTA TCA-3¢; reverse, 5¢-ACA GGC CAT GTA CTT TCC GTG TCT-3¢) and tobacco (forward, 5¢-ATG AGA GAG TGC ATA TCG AT-3¢; reverse, 5¢-TTC ACT GAA GGT GTT GAA-3¢) a- tubulinspecific ... VGCfEVY switch in regulating the expression of a zinc finger protein transcription factor isolated from Arabidopsis thaliana (AtZFP11) in both Arabidopsis and tobac...

Ngày tải lên: 16/03/2014, 06:20

... arrangement of mitochondria in the cells, in the changes in the kinetics of regulation of mitochondrial respiration by exogenous ADP and ATP, and in the direct channelling of endogenous ADP and ATP ... the observed decrease in the apparent Km for exogenous adenine nucleotides in the regulation of respiration of permeabilized bers with intac...

Ngày tải lên: 16/03/2014, 22:20

... of glycogen in the intact liver in vivo Second, during infusion of [1-1 3C ]glucose, label incorporation was observed not only into the C1 of glycogen but also the C6 , which can only occur by label ... a mechanism can lead to increases in labeling of glycogen C6 even in the presence of decreased activity of the indirect pathway, provided that the increas...

Ngày tải lên: 17/03/2014, 17:20

... upregulated during CD8+ T lymphocyte differentiation To investigate if defined microRNA profiles can be associated with CD8+ T cell differentiation status, the relative expression levels of the microRNAs ... preferentially during early memory differentiation Interestingly, not all members are regulated concomitantly, indicating a differential intra-cluster regulation in...

Ngày tải lên: 18/06/2014, 19:20

... upregulated during CD8+ T lymphocyte differentiation To investigate if defined microRNA profiles can be associated with CD8+ T cell differentiation status, the relative expression levels of the microRNAs ... preferentially during early memory differentiation Interestingly, not all members are regulated concomitantly, indicating a differential intra-cluster regulation...

Ngày tải lên: 20/06/2014, 03:20

... role in growth- rate regulation increasing growth rates in all four nutrient-limiting conditions Transcripts that were up- and downregulated with growth rate were similar to those found in the ... a protein kinase that is important in the control of eukaryotic cell growth [19] Further emphasizing the importance of TOR in growth- rate control, the study found that...

Ngày tải lên: 06/08/2014, 18:21

... 5'-AGC CGG AAG GTT ATT GTG GTA GT-3' mTLR4 lower 5'-TGC CGT TTC TTG TTC TTC CTC T- 3' mTLR6 upper 5'-ATA CCA CCG TTC TCC ATT T- 3' mTLR6 lower 5'-GAC GTG CTC TAT CAT CAG TG-3' FACS sorting, by using ... inflamed joint activated and memory T cells can pass endothelial barriers TLR ligands can activate T cells independent of antigenic specificity release of inflammatory cytoki...

Ngày tải lên: 09/08/2014, 01:23

... complexes in yeast: mining large scale protein- protein interaction screens Bioinformatics 2003, 19:1901-1908 Manke T, Bringas R, Vingron M: Correlating protein- DNA and protein- protein interaction ... Detailed1view of the main clusters in the network linking annotated protein complexes and regulons Detailed view of the main clusters in the network linking annotated prot...

Ngày tải lên: 09/08/2014, 20:20

... article as: Schuler et al.: Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana BMC Plant Biology ... incorporated into the GSEA tool of GeneTrail as individually defined categories Contrary to the GeneTrail- predefined categories the genes of MapM...

Ngày tải lên: 11/08/2014, 11:20