The functional investigation of forkhead factor FOXQ1 in hum

The functional investigation of forkhead factor FOXQ1 in human breast and colon cancers

... THE FUNCTIONAL INVESTIGATION OF FORKHEAD FACTOR FOXQ1 IN HUMAN BREAST AND COLON CANCERS QIAO YUANYUAN MRes, Newcastle University, UK A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... that FOXQ1 has potential therapeutic significance against breast cancer progression and invasion In this study, the functional role of FOXQ1 was investi...

Ngày tải lên : 10/09/2015, 15:51

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The information content of risk factor disclosures in quarterly reports

... providing increased discretion to managers in this scenario Information Content of Quarterly Reports Research on the information content of quarterly reports investigates whether there is broad informational ... contain updates to those Risk Factors (including the addition of new Risk Factors facing the firm) Thus, while disclosures in the 10-K filing s...

Ngày tải lên : 30/09/2015, 16:44

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Understanding the functional roles of intrinsic protein disorder in NFkB transcription factors

... verified intrinsically disordered regions[46] 1.3.3 Functional Conservation of Intrinsic Protein Disorder The functional importance of intrinsically disordered proteins and protein regions raises the ... Role of Intrinsic Protein Disorder in Cell Signaling In the context of cell signaling, intrinsically disordered proteins and regions have been associated w...

Ngày tải lên : 12/10/2015, 17:35

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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx

... evaluation of heme dynamics in cultured cells Role of heme metabolism in cellular heme content Regulatory role of free heme in expression of HO-1 To evaluate the contribution of heme synthesis and ... HO-1 protein was also induced by the treatment with HO-2 siRNA in HepG2 cells These results indicate that the down-regulation of HO-2 expression is...

Ngày tải lên : 19/02/2014, 05:20

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Báo cáo khoa học: Functional analysis of disease-causing mutations in human galactokinase potx

... group of GHMP kinases in which proton transfer does not play a major role in the rate determining step of catalysis That ﬁve of the 10 disease-causing mutations resulted in insoluble protein in ... play a major role in the rate-determining step of catalysis Several of the disease-causing mutations are not soluble following induction in E coli Although all the mut...

Ngày tải lên : 08/03/2014, 02:20

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Báo cáo khoa học: Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase pot

... Timson Disease-causing mutations in human GALE Fig Crosslinking of wild-type and disease-causing mutants of UDP-galactose 4-epimerase (GALE) Crosslinking was carried out with N-(3dimethylaminopropyl)-N¢-ethylcarbodiimide ... during puriﬁcation Kinetic analysis of disease-causing mutations The steady-state kinetic parameters of each of the nine disease-causing m...

Ngày tải lên : 23/03/2014, 11:20

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Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf

... components The profile was similar to that induced by a combination of IL-1/TNF, which might indicate the involvement of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by ... multiple MMP mRNAs by S aureus in human dermal and synovial fibroblasts Multiple MMP mRNA profile in dermal and synovial fibroblasts in respo...

Ngày tải lên : 09/08/2014, 08:23

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Báo cáo y học: "The economic burden of inpatient paediatric care in Kenya: household and provider costs for treatment of pneumonia, malaria and meningitis" ppsx

... predominantly based on inexpensive first line drugs and in most sites laboratories conducted only basic aspects of CSF analysis, and very rarely any imaging investigations For malaria and pneumonia ... facility type and significantly increase the body of data available in Kenya These costs can be interpreted as approximate values for disease specific treatment costs...

Ngày tải lên : 13/08/2014, 11:22

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Báo cáo y học: " The economic impact of chronic fatigue syndrome in Georgia: direct and indirect costs" pptx

... conceiving of the idea to measure direct and indirect costs related to CFS and for his role as CDC’s principal investigator of the study, Dr Martin Meltzer of CDC for his review of the manuscript, and ... state This study is a first step in using cost-effectiveness analyses to identify the economic impact of CFS and may assist in future research by direct...

Ngày tải lên : 13/08/2014, 11:22

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Investigating the Biosynthetic Pathway of Polyacetylenic Natural Products in Fistulina hepatica and Echinacea purpurea

... Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Investigating the Biosynthetic Pathway of Polyacetylenic Natural Products in Fistulina hepatica and Echinacea purpurea For the ... Polyacetylenic Natural Products in Fistulina hepatica and Echinacea purpurea Major Professor: Robert E Minto Polyacetylenic natu...

Ngày tải lên : 24/08/2014, 11:28

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Biochemical identification and functional characterization of microrna target interactions in growth control and cancer transformation

... characterizations of miRNA -target interactions involved in growth control and cancer transformation I used biochemical immunoprecipitation against Drosophila Ago1 (Ago1-IP) to isolate and purify Ago1/miRNA/mRNA ... protein (green) and GW182 (blue) GW182 proteins contain an N-terminal AGO-binding domain, which provides multiple binding sites for Argonaute proteins and...

Ngày tải lên : 09/09/2015, 10:17

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Báo cáo y học: "Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage" potx

... chondrocytes within the cartilage matrix Besides quantifying the relative percentage of CD166+ chondrocytes by immunofluorescence, analyzing the zonal distribution of these cells within the matrix of ... protocol by Ozbey and colleagues [21] (see Materials and methods) Interestingly, the distribution of the CD166+ cells in OA and normal samples was not uniform bu...

Ngày tải lên : 12/08/2014, 15:23

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Tài liệu Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007 ppt

... E.T., and Holmes, J., 2008, Investigation of organic chemicals potentially responsible for mortality and intersex in fish of the North Fork of the Shenandoah River, Virginia, during spring of 2007: ... liter (pg/L) Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the...

Ngày tải lên : 14/02/2014, 08:20

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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf

... bonds involving Gly372 in factor VIIa especially in the vicinity of the S1 pocket [11 ,34 ], in the rst part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8 ,35 ], ... Ser 333 (185), connects activation loops and and supports the activation domain by stabilizing Ala369(221A) and the Cys340(191)Cys368(...

Ngày tải lên : 18/02/2014, 08:20

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