Modeling of tumor growth and optimization of therapeutic protocol design

... status and achievements of mathematical modeling of both avascular and vascular tumor growth It included the models of avascular tumors, multicellu- 18 2.1 Mathematical modeling of cancer growth ... ﬁeld of modeling of avascular tumor growth has been quoted extensively and form the basis for most of the future works According to Burton (1966), the tumor growth decrease happens because of the ... the fundamentals of cancer growth and unique features of a given therapy and its protocols 1.1.1 Role of process systems engineering in cancer therapy Mathematical modeling and simulation is...

Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps

... the ultimate goal of evaluating and optimizing therapeutic intervention within the contexts of these models [11] In this report we describe a kinetic model of tumor transport in the craniospinal ... of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one compartment may threaten tumor ... levels of N-cadherin were seen in astrocytic tumors that had disseminated via the CSF [28] The values of kshed and kadh may in part be functions of the status of proteins such as the cadherins in tumors...

báo cáo khoa học: " Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-a" doc

... al.: Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-a Journal of Experimental & Clinical Cancer Research 2011 30:22 Figure 10 Effects of UTI and ... in breast cancer and the effects of ulinastatin on its expression level Chin J Biol 2009, 22:548-551 10 Gong Y, Sun X, Huo L: Expression of cell adhesion molecules, CIM 4s and Ecadherin, and ... UTI and TAX on the weight and restraining rate of breast tumor xenografts in nude mice Figure Effects of UTI and TAX on IL-8 mRNA levels in MDAMB-231 cells Figure Effects of UTI and TAX on transplanted...

Expression and editing of MicroRNA 376 cluster in human glioblastomas role in tumor growth and invasion

... EXPRESSION AND EDITING OF MICRORNA- 376 CLUSTER IN HUMAN GLIOBLASTOMAS: ROLE IN TUMOR GROWTH AND INVASION YUKTI CHOUDHURY (B.Sc., NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... Analysis of Adenosine-to-Inosine editing of miR376 cluster in gliomas 63 Introduction and aims 63 3.2 Editing analysis of primary miRNAs in gliomas 3.3 Editing analysis of primary miRNAs in glioma ... site-specific editing Similarity of structures and location of editing sites in coding sequences of Gabra-3 and GluR-B, and non-coding sequences of pri-miR-376c and pri-miR-376a2 Adapted from (Wahlstedt and...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... 4641 Therapeutic aspects of VEGF in brain diseases M Shibuya which to rapidly and efﬁciently suppress vascular leaks during the clinical course of brain diseases or during the treatment of brain ... Shibuya Therapeutic aspects of VEGF in brain diseases [3] The BBB mainly consists of a strong interaction between vascular endothelial cells and astrocytes, and the tight junctions of vascular endothelial ... tissues in the body, and the risk of edema to brain functions should be carefully considered Brain edema may increase pressure in the cranial cavity and brain tissue, resulting in suppression of blood...

Báo cáo khoa học: Quantitative modeling of triacylglycerol homeostasis in yeast – metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth potx

... sources or Triacylglycerol mobilization in yeast as sinks for internal ﬂuxes From a biological point of view, they allow the cell to dispose of excess metabolites by storing them in an inert form When ... inoculation of cells into fresh culture medium; and, most importantly, (c) yields a quantitative description of the utilization of TAG depots for the production of membrane lipids in order to initiate ... one-third of the rate calculated when lipolysis takes place, supporting the predominant role of TAG to provide precursors for phospholipid synthesis during the initiation of cellular growth However,...

Multilevel modeling of the influence of surface transport peculiarities on growth, shaping, and doping of si nanowires

... function The second equation of the system describes the NW axial growth due to bulk diffusion of silicon atoms from the surface to the catalyst/NW interface Here, h is the height of the NW and ... manner, the output ﬂux is the number of adatoms leaving the given region of the surface (due to the surface transport) , per one MC time step and per unit of the boundary length The surface transport ... shell growth, a sharp decrease in the surface concentration, and the corresponding slowdown of the axial growth As a result of such ﬂuctuations in the input ﬂux and the surface coverage during the...

báo cáo khoa học: "Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice" doc

... have examined the effects of manipulating Egr-1 in tumors Overexpression of Egr-1 delivered via adenovirus resulted in reduced tumor growth and diminished expression of angiogenic factors in a mouse ... slower growth in Egr-1- /- mice Mig has previously been shown to slow the growth of tumors in various models In a mouse model of Burkitt's lymphoma, intra-tumoral injection of Mig protein results in ... alteration in Mig or in tumor growth in Egr-1- /- mice, a finding that highlights the importance of the choice of model system when examining tumor/ stromal interactions http://www.jhoonline.org/content/2/1/7...

MODELING OF OPENCAST MINES USING SURPAC AND ITS OPTIMIZATION

... MODELING OF OPENCAST MINES USING SURPAC AND ITS OPTIMIZATION THESIS IS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF BACHELOR OF TECHNOLOGY IN MINING ... entitled Modeling of opencast mines using Surpac and its optimization submitted by Mr Harshit Agrawal (Roll No-108MN048) in partial fulfillment of the requirements for the award of Bachelor of Technology ... evolvement of new software’s incorporating geostatistics based modeling of pit like solid modeling, 3D block modeling, etc and development of various optimization algorithm like branch and bound...

modeling growth and stability of nanoporous materials

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Modeling and optimization of the forward osmosis process parameters selection, flux prediction and process applications

... aspects of fulfilling the main objective of this thesis 18 CHAPTER ONE – INTRODUCTION RESEARCH OBJECTIVES Modeling and Optimization of the FO Process: Parameters Selection, Flux Prediction and Process ... this thesis seeks to suggest the use of the forward osmosis (FO) process for the low cost production of clean drinking water and an alternative technology for the treatment of wastewater The FO process ... solution and for scaling-up of the FO process The challenge of predicting flux for the FO process effectively and accurately is the selection of an accurate model suitable for a wide range of testing...

Some extensions to reliability modeling and optimization of networked systems

... the reliability modeling and optimization of some networked systems The reliability of a system is usually dependent on the structure of the system and the resources spent on the maintenance and ... As many of today’s systems are large and complicated, the reliability analysis of such systems has drawn much attention, see Cook and RamirezMarquez (2009), Yeh and Lin (2009) and Huang and Xu ... some networked systems and study the related optimization problems The reliability of a system is usually dependent on the structure of the system and the resources spent on the maintenance and...

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