Predicting in vivo anti hepatofibrotic drug efficacy based on in vitro high content analysis

... high in vivo efficacy before animal testing is conducted In this project, we show that by integrating the high- content analysis and application-specific statistical analysis, we can build a high- throughput ... changes in fibrotic markers from in vitro culture 3.3.3 An in vivo anti- fibrotic drug efficacy index ranks drugs based on their in vivo effect...

Ngày tải lên: 10/09/2015, 15:48

... target variable of the GDT protocol in this study, because this variable can be easily obtained and continuously measured with the arterial waveform analysis method in a busy intraoperative setting ... more invasive and complicated than autocalibrated arterial waveform analysis because frequent manual recalibrations are required [28] and an artificial indicator limits th...

Ngày tải lên: 13/08/2014, 20:21

... hyperbolas If two solutions exist, both locations are remembered and one is later discarded based on information from other kernels On some occasions, there is no closed form solution to f(xk,l )/c ... long as both true and estimated error is large, in which case the estimates are heavily downweighted in the fusion process CONCLUSION This paper, based on analysis of the Cram´ r-Rao...

Ngày tải lên: 22/06/2014, 23:20

... FAULT DIAGNOSIS OF PERMANENT MAGNET SYNCHRONOUS MOTOR BASED ON MECHANICAL AND MAGNETIC CHARACTERISTIC ANALYSES YU YINQUAN A THESIS SUBMITTED FOR THE DEGREEM OF DOCTOR OF PHILOSOPHY ... COMPUTATION OF UNBALANCED MAGNETIC PULL AND MECHANICAL UNBALANCED FORCE IN MOTOR 64 5.1 Fundamental theory of electromagnetic force calculation 64 5.2 Introduction of...

Ngày tải lên: 16/09/2015, 12:06

... tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and nonDMARD efficacy in collagen antibody-induced arthritis Arthritis Research & Therapy 2010, 12:R105 ... instance, the non-DMARD antiinflammatory COX-2 inhibitors (a type of NSAID) routinely demonstrate efficacy in a variety of rodent arthritis models, as determined by...

Ngày tải lên: 12/08/2014, 14:21

... contributed to the design of the experiments and analysis of the data KAK contributed to the acquisition and interpretation of data RWM contributed to the conception of the studies and the critical ... with the gfp gene driven by the synthetic E/L promoter (black arrow in the bottom line) The resulting virus was designated VV Δ F2L-gfp and contained a...

Ngày tải lên: 20/06/2014, 01:20

... determine the effectiveness of the measures put in place Challenges to TB/HIV care Initiating ART in HIV infected TB patients The clinical care of HIV infected TB patients and in particular the ... ART) and the burden of TB in PLHIV Tuberculosis is appropriately gaining increasing importance to the HIV community The 'Three I's' have also gained increasing imp...

Ngày tải lên: 20/06/2014, 08:20

... any, hypersensitivity reactions in young children have been published in recent years Acetaminophen seems to cause a similar spectrum of clinical hypersensitivity reactions in a proportion of young ... than years of age,9–12 and 2% in young atopic children attending a general allergy clinic.13 An increased rate of NSAID hypersensitivity was observed with increasing age in this...

Ngày tải lên: 08/08/2014, 21:20

... show/NCT00811954?term=ACTG+5257&rank=3] doi:10.1186/1742-6405-8-14 Cite this article as: Chu et al.: Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis ... compared to the Nightingale et al placebo arm Comparison of direct and adjusted indirect comparison methods The effi...

Ngày tải lên: 10/08/2014, 05:22

... concentration of drug, the final efficacy may be significantly affected by the hormone status of the patient Most likely, β-estradiol acts by modifying intracellular levels of the active form of D4T ... separately and in combination As seen in Figure 5, in the absence of D4T susceptibility, the enhancement effect of β-estradiol in the presence of D4T is a...

Ngày tải lên: 13/08/2014, 05:21

... clinical data concerning the individual patient, particularly information relating to biomarkers However, translational integration of this large amount of information into one risk assessment is a ... can hardly be repeated with distinct cohorts Whereas the predictive power of any single variable including tumour size was limited, integration of molecular information into a u...

Ngày tải lên: 13/08/2014, 16:20

... targeting the NF-κB cascade may be promising in the treatment of asthma 1.1.5 Therapeutic strategies in the treatment of asthma exacerbation There are currently some drugs for the treatment of rhinovirus- induced ... with the residues in other site of the surface These conserved sites have been shown to be the binding sites of the receptors and t...

Ngày tải lên: 09/09/2015, 11:16

... Arylaminoalcohol 4-aminoquinolines 8-aminoquinolines Artemisinin drugs (Sesquiterpene lactone) Biguanides Diaminopyrimidines Antimalarial drug Quinine (Cinchona alkaloids) Quinidine Mefloquine ... arylaminoalcohol, 4-aminoquinolines, 8amionquinolines, sesquiterpene lactone (artemisinin), biguanides, diaminopyrimidines, sulfonamides, hydroxynaphthoquinone, and antibiotics Quinine and qui...

Ngày tải lên: 22/09/2015, 15:17

... matrine, supporting the further development of this novel delivery system for cancer therapy Materials and Methods Preparation of RGD-modified long circulating liposome (LCL) loading matrine (RGD-M-LCL) ... when the liposomes were reconstitutes in solvent Because matrine is a strongly hydrophilic and weakly alkaline drug, the encapsulation efficiency of liposomes for...

Ngày tải lên: 26/10/2012, 08:57

... precision of therapy like the intensity-modulated radiation therapy (IMRT) and the use of heavy ions demands absolute reliability of new diagnostics and treatment planning for prostate and brain ... 14 It was used to investigate whether an intracellular MR imaging is possible and to estimate the T1 relaxivity on MR (1.5 T) Historically already in 1994 electron-spin-resonance...

Ngày tải lên: 26/10/2012, 09:07