REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK ERK IN CELL DYNAMICS

... multi-domain protein, consisting of N-terminal SAM domain, C-terminal START domain and the catalytic RhoGAP domain This allows for its interaction with diverse cellular proteins, including FAK, Tensins ... light chain phosphatase (MLCP) to inactivate it and hence ensuring phosphorylation of myosin by myosin light chain kinase (MLCK) This leads to actin-myosin cross-linking, trig...

Ngày tải lên: 10/09/2015, 09:29

... Phase and G2/M Checkpoints: In the budding yeast, DNA damage surveillance mechanisms operate in G1, S and G2 phases These are the G1 DNA damage checkpoint, the S phase replication and DNA damage checkpoints, ... REGULATION OF SPINDLE BEHAVIOR BY DNA REPLICATION AND DAMAGE CHECKPOINTS IN BUDDING YEAST SAURABH RAJENDRA NIRANTAR (B.Tech.(Hons)...

Ngày tải lên: 14/09/2015, 14:03

... occurs on the transcriptional or on the translational level, the system of combined transcription translation was decoupled The inuence on the transcriptional level was investigated by in vitro transcription ... dissociation constants were derived for the inhibition of the protein expression by CSP using two models In the most simple model the inhibitio...

Ngày tải lên: 07/03/2014, 21:20

... IRF -3 responsive, including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-specific counterpart [16] The two isoforms ... ArgII expression was inhibited by MG- 132 [20], suggesting indirectly an involvement of NF-jB in ArgII regulation Our study is thus the first direct demonstration...

Ngày tải lên: 07/03/2014, 21:20

... shared by Sec14p and Sfh proteins assumes functional significance because some of the Sec14 homologues (namely Sfh2 and Sfh4), when overexpressed, complemented the sec14-related growth and secretory ... could substitute for Sec14p in its role as a regulator of phospholipid biosynthesis Under conditions where Sec14p is nonfunctional and the CDP-choline pathway for Pt...

Ngày tải lên: 30/03/2014, 15:20

... suggest that proteolytic processing is a general mechanism for the negative regulation of STAT protein function (Fig 4) Truncated forms of Stat3 , Stat5 a, Stat5 b and Stat6 , generated by the proteolytic ... cells Proteolytic regulation of Stat5 and Stat3 in mature human neutrophils Stat3 and Stat5 isoforms have been identified in differentiated human perip...

Ngày tải lên: 30/03/2014, 15:20

... recruitment to the FeLV-945 LTR might interfere with CBP availability and thereby alter the regulation of CBP- responsive genes Such alteration might then contribute to altered hematopoiesis and consequent ... regulated by CBP in a manner dependent on the presence of the 21-bp triplication (Figure 7) These results indicated that the interaction between c-My...

Ngày tải lên: 18/06/2014, 22:20

... recruitment to the FeLV-945 LTR might interfere with CBP availability and thereby alter the regulation of CBP- responsive genes Such alteration might then contribute to altered hematopoiesis and consequent ... regulated by CBP in a manner dependent on the presence of the 21-bp triplication (Figure 7) These results indicated that the interaction between c-My...

Ngày tải lên: 20/06/2014, 04:20

... is likely that the caMEKK1-induced increases in NF-κB and RAR activity are mediated by hyperactivation of p300 Effect of caMEKK1 and ectopic p300 on Sox9 activity (a) Chondroactivity cytes were ... effect of TNF-α on Sox9 activity Finally, the sensitivity of Sox9 to atRA was reduced by caMEKK1 expression Thus, the activity state of p300, the common co-factor a...

Ngày tải lên: 09/08/2014, 10:22

... treatment of ischemic stroke, a pathophysiological condition in which NMDA receptors are implicated 1.7 Tissue- type Plasminogen Activator (tPA) 1.7.1 tPA and stroke Tissue- type plasminogen activator (tPA) ... Thrombin 1.6.3.4 Tissue- type plasminogen activator (tPA) 22 23 23 24 25 26 27 27 27 29 30 30 30 32 1.7 Tissue- type Plasminogen Activator (tP...

Ngày tải lên: 11/09/2015, 10:18

... integrated iron moiety and that NO+ from SNP is responsible for its effect on ferritin synthesis Moreover, acute regulation of ferritin synthesis by NO+ is accomplished by a rapid mobilization of polysome-free ... Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site A study of iron uptake and ferro-oxidase...

Ngày tải lên: 07/03/2014, 12:20

... of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) FOREWORD We would like to present to you our study on the Regulation of Interest Rate by the State Bank ... many bankers at the conference have given voice to the regulation on Page of 20 International Finance Regulation of Interest Rate by...

Ngày tải lên: 15/03/2014, 01:20

... detection of AFB in sputum samples of patients with pulmonary tuberculosis in tertiary healthcare facilities which have a large number of cases and financial constraints Ethical Approval The study was ... (TB) laboratory investigations in tertiary healthcare facilities which have a large number of cases and financial constraints The present study aimed to re-eval...

Ngày tải lên: 15/03/2014, 03:20

... that lactate production in strain FI9078 was mediated by the enzyme encoded by the ldhB gene As expected, the enzyme produced by strain MG1363 was encoded by the ldh gene LDHB (ldhB gene product) ... Val253 and Ile254 in LDHB) The histidine and arginine residues directly involved in catalysis are identical in the two enzymes, and NADH binding is...

Ngày tải lên: 16/03/2014, 05:20