Probabilistic verification and analysis of biopathway dynamics

... PROBABILISTIC VERIFICATION AND ANALYSIS OF BIOPATHWAY DYNAMICS SUCHEENDRA KUMAR PALANIAPPAN (B.Eng, PESIT, India) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN ... natural and succinct model to work with Consequently, our work concerns the analysis of DBN models of biopathways from a model checking point of view Specifically, we first consider the prob...

Ngày tải lên: 10/09/2015, 09:25

... implemented in a series of software tools, to provide verification and analysis support for Web service composition Key words: Web Service, Web Service Composition, Service Orchestration, Service Choreography, ... verification of Web service composition from the perspective of Web service orchestration A challenge to verify Web service composition is...

Ngày tải lên: 10/09/2015, 09:21

... Real-time imaging and analysis of differences in cadmium dynamics in rice cultivars (Oryza sativa) using positron-emitting 107Cd tracer Satoru Ishikawa1*§, Nobuo ... to grains in typical rice cultivars that differed in grain Cd concentrations We used positron-emitting 107Cd tracer and an innovative imaging technique, the positron-emitting tr...

Ngày tải lên: 11/08/2014, 11:21

... skin and brain cortex (Feng et al., 20 07; Wang et al., 20 05; Stambolic et al., 20 01; Trotman and Pandolfi, 20 03; Singh et al., 20 02; Tang and Eng, 20 06a, 20 06b) AKT phosphorylation of MDM2 (AKT-MDM2) ... (CI41) and mouse hippocampal 12 neurons (Gottlieb et al., 20 02; Su et al., 20 03; Wang et al., 20 05; Ogawara et al., 20 02; Zhou et al., 20 01; Singh et al.,...

Ngày tải lên: 11/09/2015, 16:05

... Sections 3. 3 and 3. 4 Finally, novel systemic behaviors of the system are inferred and predicted from the simulation results (Sections 3. 5 and 3. 6) 34 3. 2 Formulation of kinetic models Figure 3- 1 Kinetic ... p 53] n1 k [ p 53] v3 = j3n1 + [ p 53] n1 v4 = k [PIP 2] k {[PIPT ] − [PIP3]} = j + [PIP 2] j + [PIPT ] − [PIP3] vm = k m [PTEN ][PIP 3] j m + [PIP3] (3- 3) k [ p 5...

Ngày tải lên: 11/09/2015, 16:05

... damped oscillations of p53 and MDM2 protein levels in cell populations of mouse fibroblasts and human breast cancer epithelial MCF-7 cells, following 5Gy of IR The dynamics of the p53-MDM2 oscillator ... populations of human wild-type and Bloom’s syndrome patients’ fibroblast, following induction of DNA damage either by 20 J/m2 of UV radiation or 2.5 Gy of ionizing rad...

Ngày tải lên: 11/09/2015, 16:05

... (uM) 1 .5 1. 75 0.2 0. 25 0 .5 0. 75 0 .5 1. 25 [AKTT] (uM) 0. 75 1 .5 1. 75 1 .5 1. 75 120 350 D C 110 300 100 90 250 80 200 0. 25 0 .5 0. 75 1. 25 [AKTT] (uM) 1 .5 1. 75 70 0. 25 1. 25 [AKTT] (uM) Figure 5- 24 Oscillation ... Analog and digital forms of p53 oscillations Digital [TP53] 5. 7.2 [p53] uM Analog Tim e Figure 5- 20 Schematic illustration of analog an...

Ngày tải lên: 11/09/2015, 16:05

... 53 55 57 59 61 63 65 67 69 71 73 75 77 79 Figure 6- 1B Percentage length of each exonic region relative to its flanking intronic region To illustrate the fact that the exonic region of the dystrophin ... in Figure 6- 1 121 1,000,000 N u m b e r o f b a s e p a irs 100,000 10,000 1,000 100 10 1 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 Exon 43 45 47 49 51 53 55 57 59 61 63...

Ngày tải lên: 11/09/2015, 16:05

... 0 .7 0 .7 0 .7 0.6 0.6 0.6 0.5 0.5 0.5 0.4 0.4 0.4 0.3 0.3 0.3 0.2 0.2 0.2 0.1 0.1 0 90 92 94 96 98 100 102 104 106 108 0.1 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 19 20 21 22 23 24 25 26 27 ... only 17% of target sites of (+) AONs had one or more clusters, they were manifested in 52% of target sites of (++) AONs Set B also exhibited similar trends: 71 %, 70 % and...

Ngày tải lên: 11/09/2015, 16:05

... systematically in place of current trial -and- error means, which could reduce the cost and waiting time of therapy In conclusion, the use of models has greatly aided in the understanding of the two intracellular ... dynamics between the two steady states of the system leads to the understanding of how cells regulate the switch between cell survival and death Interestingly,...

Ngày tải lên: 11/09/2015, 16:05

... specific and other known or unknown details of the regulation of p53 and AKT In particular, different forms of p53 are ignored to reduce the number of variables and unknown mechanistic and kinetic ... genetic diseases Examples of such 163 genes are beta-globin gene in thalassemia (Suwanmanee et al., 2002; Gorman et al., 2000; Sazani and Kole, 2003; Dominski and Kole, 199...

Ngày tải lên: 11/09/2015, 16:05

... system A system- level understanding of the biological process and elucidating of the systems behaviors can then be obtained from the insights of such analyses The dynamics of two intracellular processes ... not a standalone process Analyses show that dynamics of co-transcriptional binding accessibilities of AON target sites could statistically correlate with efficacy and...

Ngày tải lên: 11/09/2015, 16:05

... of International Business and Cooperation, 2009 [17] Ministry of Energy and Mining Renewable Energy in Serbia Ministry of Energy and Mining, 2009 [18] Statistical Office of the Republic of Serbia ... Republic of Serbia Strategy of development of energy industry of Republic of Serbia until 2015, draft report, 2005 [6] EPS – Electric Power Industry...

Ngày tải lên: 05/09/2013, 16:10

... the company size and the characteristics of the career Web sites Each of the Fortune 100 companies’ Web sites was visited to determine the content of the corporate career Web sites Table shows ... Number of Companies 19 20 24 12 A Content Analysis of Fortune 100 Career Web Sites In this section, we analyze e-recruiting practices of the Fortune...

Ngày tải lên: 24/10/2013, 08:20

... quan mạng truyền hình cáp, đo kiểm đánh giá can nhiễu mạng truyền hình cáp, tình hình triển khai truyền hình cáp cấc tỉnh duyên hải phía bắc Việt Nam Nghiên cứu ảnh hƣởng can nhiễu mạng truyền hình ... nhận xét mạng A 2.1 Truyền hình cáp EG B 2.2 Truyền hình cáp ALPHA C 2.3 Truyền hình cáp Minh Trí D 2.4 Truyền hình cáp Thá...

Ngày tải lên: 26/11/2013, 20:44