multi scale analysis of angiogenic dynamics and therapy

... conception and design, acquisition of data, and analysis and interpretation of data; 2) have been involved in drafting the manuscript; and 3) have read and given approval of the final version of the ... results of the Cox regression analysis (Table 2), where both univariate and multivariate analysis indicated a null association with history of injection drug use Time-updated analysis of current ... Table Of the 269 ALIVE participants, 100% had a history of injection drug use (by design), while only 37% (475/1,301) of WIHS participants and 14% (99/696) of MACS participants had such a Page of...

Ngày tải lên: 10/08/2014, 05:20

... to 61.2% of the original patient total Of the total number of patients who entered in each quarter of 2005, at the end of the study period (after 12, 11, 10 and quarters for waves 1, 2, and respectively), ... apply in the case of GIPAP and include (a) flexibility in terms of organizing and delivering care where needed; (b) scale economies; (c) country links, enabling delivery of care and assistance in ... Institutions to be offered treatment and enroll onto the program Note TMF has an agreement with each of the GIPAP physicians and Institutions in all countries it operates A Memorandum of Understanding (MOU)...

Ngày tải lên: 11/08/2014, 14:21

... and coordinated the study, participated in data cleaning and data analysis, and was the lead author on this paper ED, LS and SM contributed to data analysis and writing of the manuscript MK and ... guidelines, and two TDF-based FDCs Three of these were approved through Waning et al Globalization and Health 2010, 6:9 http://www.globalizationandhealth.com/content/6/1/9 Page of 19 Volu ume of ARV ... Market dynamics for three-in-one FDC ARVs The market dynamics of FDC versions of ARVs are indicative of market efficiency over the past several years, at least using typical measures of competition...

Ngày tải lên: 11/08/2014, 14:21

... regulating the expression of a diverse set of genes in many different tissues and stages of development Here, we present the results of our first large -scale analysis of the REDfly CRMs to define ... assessment of alignment of simulated non-coding sequences [47] We assessed both the conservation of the CRM sequences themselves and the conservation of sequences up to kb to each side of the CRM and ... andthroughtheproperties ofCRMs), REDfly analysisscores Additionalandconservation andultra-conservedinformationdata of of and 17 Acknowledgements 18 We thank Casey Bergman and Mathieu Blanchette for comments...

Ngày tải lên: 14/08/2014, 07:21

... VERIFICATION AND ANALYSIS OF BIOPATHWAY DYNAMICS SUCHEENDRA KUMAR PALANIAPPAN (B.Eng, PESIT, India) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN COMPUTER SCIENCE SCHOOL OF COMPUTING ... Clarke and Emerson [101] and Quellie and Sifakis [102] Model checking has been widely used in domains of embedded systems, software engineering etc., to find critical bugs in hardware and software ... interested in the dynamics of these pathways Figure 3.2(a) shows a simple network consisting of reactions: a pair of reversible reactions and one irreversible reaction The dynamics of such a network...

Ngày tải lên: 10/09/2015, 09:25

... 2000; Momand et al., 2000; Bond et al., 2005; Piette et al., 1997; Momand and Zambetti, 1997; JuvenGershon and Oren, 1999; Moll and Petrenko, 2003; Iwakuma and Lozano, 2003; Alarcon-Vargas and Ronai, ... most cell types (Nicholson and Anderson, 2002; Kandel and Hay, 1999; Franke et al., 2003; Coffer and Woodgett, 1991; Jones et al., 1999; Bellacosa et al., 1993; Brazil and Hemmings, 2001; Datta ... 13 and 14; edges 15 and 16; edges 15, 17 and 18; edges 19, 16 and 14; edges 20 and 21) Moreover, active caspases further upregulate the activation of more caspases by inducing the release of...

Ngày tải lên: 11/09/2015, 16:05

... Basal induction of MDM2 Degradation of MDM2 Degradation of MDM2a Hill coefficient of p53-dependent production of PTEN Hill coefficient of p53-dependent production of MDM2 Sum of [PIP2] and [PIP3] ... constant of p53-dependent production of PTEN Phosphorylation of PIP2 Michaelis constant of phosphorylation of PIP2 PTEN dephosphorylation of PIP3 Michaelis constant of PTEN dephosphorylation of PIP3 ... rate of MDM2 degradation; v12 : rate of MDM2a degradation 37 To minimize the number of kinetic equations in Model M1, kinetic equations are not assigned to AKT and PIP2 Instead, dynamics of AKT and...

Ngày tải lên: 11/09/2015, 16:05

... damped oscillations of p53 and MDM2 protein levels in cell populations of mouse fibroblasts and human breast cancer epithelial MCF-7 cells, following 5Gy of IR The dynamics of the p53-MDM2 oscillator ... populations of human wild-type and Bloom’s syndrome patients’ fibroblast, following induction of DNA damage either by 20 J/m2 of UV radiation or 2.5 Gy of ionizing radiation (IR) ... following: periods of oscillation are to hrs; peaks of MDM2 oscillations lag behind p53 peak for 1.5 to 2.5 hrs; periods of oscillations decrease with increasing IR intensity; and peaks of p53 pulses...

Ngày tải lên: 11/09/2015, 16:05

... Oscillation profiles of p53 and MDM2a as functions of [AKTT] at four representative values of ρ Using Model M4, oscillation profiles of p53 and MDM2a are determined for the range of [AKTT] (the ... Section 2.3 of Chapter 99 5.6.2 Analysis of the Apoptotic Model For the purpose of analysis, as well as based on experimental observations (Adams and Cory, 2001; Cory and Adams, 2002; Danial and Korsmeyer, ... regulation of pro-apoptotic and pro-survival genes by p53 and AKT Kinetic model in which the regulation of pro-apoptotic BAX and BAD proteins and prosurvival BCL-2 and BCL-XL proteins by p53 and AKT...

Ngày tải lên: 11/09/2015, 16:05

... large size of the gene and large numbers of exons, co-transcriptional splicing is an effective way to limit the number of possible splice sites and thereby decrease the probabilities of incorrect ... intronic regions, the percentage of the length of an exon relative to the total length of its flanking intronic regions is plotted Most of the exons constitute less than 1% of their intronic lengths ... domain, many choices of exons can be skipped depending on the position of the mutations in DMD patients, of which more than 75% of DMD patients would benefit from the skipping of these exons (Aartsma-Rus...

Ngày tải lên: 11/09/2015, 16:05

... nucleotides meeting criterion of analysis (see main text) in target sites of (++), (+) and (–) AONs of Set A, and of (++) AONs of Set B (***) (B) Box-plots for scores of groups of consecutive nucleotides ... particular step of transcriptional analysis (B) 3’ end of AON target site Aw ay from ends of AON target site L4_OR L4 _AND 5’ end of AON target site Sequential steps of transcriptional analysis Figure ... 5th-percentile of L3 scores of (++) AON target sites (Appendix A-18) On the other hand, target sites of h45AON5 and h46AON4 graded as (+) and target sites of h51AON29, h55AON5 and h77AON2 graded...

Ngày tải lên: 11/09/2015, 16:05

... systematically in place of current trial -and- error means, which could reduce the cost and waiting time of therapy In conclusion, the use of models has greatly aided in the understanding of the two intracellular ... dynamics between the two steady states of the system leads to the understanding of how cells regulate the switch between cell survival and death Interestingly, bistability between apoptotic and ... accessibilities of AON target sites could statistically correlate with efficacy and efficiency of 94% of previously reported AONs in their ability to induce selective removal of exons in the...

Ngày tải lên: 11/09/2015, 16:05

... specific and other known or unknown details of the regulation of p53 and AKT In particular, different forms of p53 are ignored to reduce the number of variables and unknown mechanistic and kinetic ... algorithm, the accuracy of the model is limited by the accuracy of such algorithms However, the use of vast numbers of predicted secondary structures that averaged 44,582 of them per exon (Appendix ... study will also include these published models and all known downstream apoptotic pathways from p53 and AKT (Section 2.5 of Chapter 2) to understand how the predicted apoptotic threshold at the...

Ngày tải lên: 11/09/2015, 16:05

... system A system- level understanding of the biological process and elucidating of the systems behaviors can then be obtained from the insights of such analyses The dynamics of two intracellular processes ... not a standalone process Analyses show that dynamics of co-transcriptional binding accessibilities of AON target sites could statistically correlate with efficacy and efficiency of 94% of previously ... published in Wee and Aguda (2006), as attached in Appendix A-1 Interestingly, intracellular protein levels of p53 and MDM2 have been observed in single-cell experiments of specific cell types and in mouse...

Ngày tải lên: 11/09/2015, 16:05

... forest and tropical grassland Figure Relationships between proportions of functional groups and age 26 of forests Figure Relationships between proportions of functional groups and age 27 of forests ... community and population dynamics to one another 40 CHAPTER ANT SUCCESSION DYNAMICS IN A SECONDARY FOREST OF SINGAPORE Introduction The main island of Singapore is located off the southern tip of the ... (Holldobler and Wilson, 1990) The ants use their mandibles for a variety of purposes, including manipulation of objects, defense and communication (Holldobler and Wilson, 1990) Third, ants have a pair of...

Ngày tải lên: 29/09/2015, 13:01

... the standard deviation of the residuals from the style analysis of the hedge fund strategy S using the nine indices, σI is the standard deviation of the residuals from the style analysis of the ... concept of concordance and discordance which informally says that a pair of random variables are concordant if large values of one tend to be associated with large values of the other and small ... estimates the standard error of the parameter estimate by the empirical standard deviation of the B replications The result is called the bootstrap estimate of standard error and is evaluated...

Ngày tải lên: 16/04/2013, 20:00

... Overlay of sewered area Overlay of sewered area and households Separation of unsewered households Fig - Separation of unsewered households of Minasebashi basin of Mizunashi River - 147 - Journal of ... calculation of pollution load of the individual basin, on the basis of the results of the river flow survey (Fig 17) In the case of Mizunashi River and the upstream basins of Kuzuha River, because of ... Journal of Water and Environment Technology, Vol 9, No.2, 2011 data of Japan and the data of each drainage basin were prepared in GIS and were calculated based on area proportion (Fig 4) Land use...

Ngày tải lên: 05/09/2013, 10:17

... different shapes of micro-channels which have been already developed and newly designed as well The result of analysis shows that characteristics of flow such as velocity, uniformity, and flow rate, ... the divergence of the mass flux through diffusion and convection Multiple species are considered in the gas phase only, and the species conservation equation in multicomponent, multi- phase flow ... 2.73 K), and this leads to prevent drying out of the membrane and excessive thermal stresses that may result in rupture of the membrane, and therefore less thermal management problems, and achieve...

Ngày tải lên: 05/09/2013, 14:58

... stand out for their frequent use of lexis to express notions of increase and decrease The English texts used were minutes of the meetings of the Monetary Policy Committee of the Bank of England, ... occurrences 24 of increase, increasing, increases and increased The results of this analysis are presented in Tables and 4, below Table 3a: Expressions of increase, Bank of England Monetary Policy ... studies of different aspects of economics discourse in recent years, several of which are published in Dudley-Evans and Henderson (1990) and Henderson, Dudley-Evans and Backhouse (1993) The first of...

Ngày tải lên: 07/09/2013, 12:58

... formal ones Modality Modality often appears in both two kinds of letters with a great deal of number The use of active and passive voice Our analysis of two kinds of letter shows that: the passive ... difference on production and reception We use our mouths and ears for spoken discourse and our hands and eyes for witten one Brown and Yule (1983:13 ) point out that spoken and written discourse ... The first is used for the establishment and maintenance of human relationships (interactional use) and the second for the working out of and transference of information (transactional use ) To...

Ngày tải lên: 18/12/2013, 19:50