The structure basis for burkholderia pseudomallei hcp induced multinucleated giant cell formation

... pseudomallei induced MNGC formation Moreover, the in situ substitution of these hcp1 residues in B pseudomallei abolishes MNGC formation and Hcp1 secretion Taken together, these data provide structural ... that form the shaft and the needle tip respectively 76,96,97 The contraction of TssA/B is thought to be responsible for their ejection into the extracellular milieu...

Ngày tải lên: 10/09/2015, 09:25

... us the ratio of two power levels, that is it expresses the gain of the system But some time we want to express the exact output power of a system rather than the gain In that case, we compare the ... dBm signal (10 mW) the noise level has to be less than -20 dBm (10 microW) Shanon Theorem: Mathematical guidelines have been established to determine the maximum theoretical da...

Ngày tải lên: 10/12/2013, 08:15

... exposure of liver cells to FFAs Interruption of TAG synthesis in conditions of excess availability of SFAs is the key point in the molecular mechanism of SFA-induced lipotoxicity It is suggested ... constitutes the initiating event in the process of lipotoxicity Stearate has to be activated in order to be toxic The first enzyme involved in me...

Ngày tải lên: 14/02/2014, 22:20

... Stereoview of the RMD monomer The cofactor-binding domain and the substratebinding domain are shown in aqua and light sand, respectively; the APPR portion of the cofactor (dark gray) and the ligand ... disease and reduced lung function [20] An eight-gene cluster encodes functions for synthesis and export of A-band O polysaccharide [21,22], and contains genes...

Ngày tải lên: 16/03/2014, 01:20

... 1992) The total natural populations of this species extend over approximately 380 000 hectares The black pine forests found in the Sistema Ibérico account for two-thirds of the total black pine formations ... 1896), and they provided very accurate descriptions of the main forests of this species When describing black pine woods along the Sistema Ibérico,...

Ngày tải lên: 08/08/2014, 19:21

... form of folate in circulation is 5-methyl tetrahydrofolate (5-methyl THF) [7] a) b) Figure Chemical structure of folic acid and folate derivatives a) Constitution of folic acid b) Tetrahydrofolate ... crystal structure of FRα -folic acid complex which provided the molecular basis for the high affinity binding Folate receptor is a globular protein which con...

Ngày tải lên: 09/09/2015, 11:28

... Pseudomonas syringae and R solanacearum have been elucidated using Arabidopsis as a plant model (Quirino and Bent, 2003) 3.2 Materials and Methods 3.2.1 Plant Materials 3.2.1.1 Tomato and Arabidopsis ... and can be isolated from rice paddy fields in endemic areas such as Thailand Dharakul and Songsivilai first raised the question of a relationship between B pseudo...

Ngày tải lên: 09/10/2015, 10:49

... accelerating the formation and breakdown of the catalytic intermediate, providing a kinetic link between the first two reactions of chlorophyll biosynthesis, with the signalling molecule MgP as the common ... Scheme Diagram of the branchpoint of tetrapyrrole biosynthesis, showing the participation of the Mg chelatase H subunit in both the chelatase and m...

Ngày tải lên: 20/02/2014, 02:21

... In particular if X is a set of reals of cardinality ℵ1 , then X serves as a single -element basis for the class of uncountable separable linear orders PFA is a strengthening of the Baire Category ... C UNCOUNTABLE LINEAR ORDERS 671 ∗ Conjecture (PFA) [4] The orders X, ω1 , ω1 , C and C ∗ form a five element basis for the uncountable linear orders...

Ngày tải lên: 06/03/2014, 08:21

... contribute to the susceptibility of E coli model membranes to the action of AP1 An important determinant of the susceptibility of membranes to a-AMPs is the packing characteristics of the individual ... hypothesis of Tytler et al [48], it may be that insertion of the inverted wedge shape formed by the AP1 a-helix into membranes of E coli leads to the...

Ngày tải lên: 07/03/2014, 12:20

... structures of VioC hydrogen bond to the peptide group of Ser158 In addition, the guanidinium group of the l-arginine side chain forms salt bridges to the closely adjoined side chains of the acidic ... by the hydroxyl group of the side chain of Ser224 and the carboxamide group of the side chain of Gln137 Gln137 is suitably oriented to interact with the...

Ngày tải lên: 16/03/2014, 02:20

... partial active enzyme intermediate, and kfast and kslow are A nity labelling of maize GST I (Eur J Biochem 271) 3505 the rate constants for the slow and fast phase of the reaction Analysis was ... B-factors of Met121 at ˚ ˚ the A and B chains are 26.67 A2 and 49.26 A2 , and the ˚ and 79.30 A2 , respect˚ B-factors of S atoms are 38.14 A ively It is the...

Ngày tải lên: 16/03/2014, 16:20

... with the symmetry of space group C2221 Overall hydrophobic NNRTI interactions to wild-type and K103N mutant RT The interactions of Efavirenz, MSC194 and PNU142721 to wild-type RT and the K103N mutant ... study we present the structural indications for the role of K103 and N103 in drug binding and the structural implications for the inhib...

Ngày tải lên: 18/03/2014, 01:20

... further oligosaccharides that are fragments of NA2F The structural information is complemented by thermodynamic parameters of binding determined by means of isothermal titration calorimetry for ... second conformation of the side chain of Glu221, which also adopts two conformations but not correlated with the anomeric form of the bound mannose is shown in dark gr...

Ngày tải lên: 23/03/2014, 11:20

... CbHs CdHs CeHs CfH NH CaH CbH CdHs CeHs NH CaH CbH CdH NH CaH CbH CdHs CeHs CfH NH CaH CbH CbHÂ CdHs CeHs OH NH CaH CbH3 NH CaH CbH CcH3 NH CaH CbH CbHÂ CcH CdH3 CdH3Â NH CaH CbH3 NH CaH CbH ... NH CaH CbH CbHÂ NdH NH CaH CbH CcH3 NH CaH CbH CcH3 CcH3Â NH CaH CbH CbH CdHs CfH NH CaH CaHÂ NH CbH CbHÂ CdHs CeHs CfH NH CaH CbH CdHs CeHs CfH NH CaH CbHs CcH CeH3 CaH CbH CcHs CcHÂ CdH3 3.25 ... po...

Ngày tải lên: 23/03/2014, 17:22