CELL GEOMETRIC CONSTRAINTS INDUCE ACTOMYOSIN CONTRACTILITY DEPENDENT CHANGES IN GENE EXPRESSION AND CHROMOSOME POSITIONING

... repositioning Nuclear lamina which includes lamin and lamin binding proteins mediates chromosomal positioning (125, 126) Along with chromosome positioning, gene clustering has also been considered ... by geometrical cues and how it correlates with chromatin compaction and gene expression The critical molecular intermediates involved in the geometry regulated chromatin compa...

Ngày tải lên: 10/09/2015, 09:04

... 107.7 interferon, alpha-inducible protein 27 (ISG12, P27) 1.9 interferon -induced protein 35 5.0 Interferon -induced protein 44, p44 8.4 interferon -induced protein 44-like 2.2 interferon induced ... relapsed by the end of treatment Changes in Global Gene Expression Gene expression in PBMC changed dramatically and rapidly during PEG-interferon- α2b (PegIntron™) /ribaviri...

Ngày tải lên: 18/06/2014, 15:20

... of gene Birnbaum et al [5] used binary coding, principal component analysis and k-means clustering to find dominant expression patterns among the 5,712 differentially expressed genes (defined ... as coordinates, resulting in five points in a multidimensional space The Euclidian geometric distance between these points was calculated To obtain the clustering, the points closest in spa...

Ngày tải lên: 09/08/2014, 20:20

... that the initiating pathway determines a distinctive expression phenotype in tumors In addition, using proteins as markers of cell phenotypes, we showed that initiating oncogenes determine the developmental ... discussion Mammary tumors in MMTV-Wnt-1 transgenic mice have an expression profile distinct from that seen in mammary tumors induced by MMTV-Neu Compari...

Ngày tải lên: 14/08/2014, 14:22

... concentrations during defence response in Norway spruce embryogenic cell suspension cultures induced by intracellular protein and wall preparations from Sirococcus strobilinus mycelia MATERIAL AND METHODS ... ester-bound (SWE) and soluble glycoside-bound (SG) phenolic acids in control cells of embryogenic cultures of Norway spruce (C) and in the...

Ngày tải lên: 07/08/2014, 10:21

... Enclosing branches in the bag within the period of increasing glutathione concentrations resulted in an immediate decrease in the glutathione content of the needles; when the bag was removed, the glutathione ... rhythm in the glutathione concentration of spruce needles is superimposed on the seasonal changes This result is surprising, since one during spr...

Ngày tải lên: 09/08/2014, 03:24

... (MAR) in Intron of Bmy gene and the absence of such sequences in other sites of the gene intensively binding TBPs indicate that TBP binding is not dependent on the presence of MAR TBP binding and ... DNA and tight DNA-protein complexes along barley chromosomes 1H and 7H A The distribution of DNA fragments containing given microsatellites in free D...

Ngày tải lên: 12/08/2014, 03:20

... electrocardiogram, clinical laboratory tests (hematology, clinical chemistry, coagulation), and pulmonary function prior to inclusion into the study Study design and bronchoscopy It was predefined that ... compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome The Acute Respiratory Distress Syndrome Network N Eng...

Ngày tải lên: 12/08/2014, 15:21

... 10.1080/19425120.2013.824941 ARTICLE Indication of Density- Dependent Changes in Growth and Maturity of the Barndoor Skate on Georges Bank Karson Coutr´ * e Marine Science Center, University of New England, 11 Hills Beach ... using the index of 263 GROWTH AND MATURITY OF BARNDOOR SKATE SEXUAL MATURITY Females.—Sexual maturity in females w...

Ngày tải lên: 04/09/2015, 12:38

... suppression of respiration during hypoxia In the absence of differential regulation of a speci c nuclear gene coding for the subunits of CytOX, changes in the microenvironment of the cell may induce alterations ... modulates the expression of mRNAs for CytOX subunits and also the catalytic activity of the enzyme complex Our results show tha...

Ngày tải lên: 20/02/2014, 23:20

... that the inhibitory effect of NAMI-A on c-myc gene expression may have occurred by suppressing ERK1/2 activation and activity elicited by PMA-generated signals Unlike the ras gene family, mutations ... relationship between the inhibitory effect of NAMI-A on ERK1/2 activation and NAMI-A- induced down regulation of c-myc gene expression NAMI-A inhibits...

Ngày tải lên: 21/02/2014, 01:21

... present the evolution of the voting power of controlling shareholders in the main sample of unifying firms, and in the control sample of firms that chose to maintain their dual share structure Looking ... of their voting power by increasing their holdings in advance And, after the unification, they may reverse the initial erosion in their votin...

Ngày tải lên: 07/03/2014, 01:20

... This report outlines the design of novel DNAzymes that target uPAR mRNA as a method of inhibiting its expression and thereby decreasing the invasive potential of tumor cells Results In vitro cleavage ... Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta...

Ngày tải lên: 16/03/2014, 22:20

... during walking are quite different from those involved in maintaining upright posture During standing, the goal is to maintain the body's center of gravity (CG) within the base of support The initiation ... Hz The smoothed coordinates then became inputs to the standard link-segment model ing during walking These variables are presented in the Table Results and Discussi...

Ngày tải lên: 28/03/2014, 19:21

... confirm the observed changes in dmeglob1 expression levels under hypoxia, we used LDH as a positive control for hypoxia-induced changes in gene expression LDH expression in Drosophila cell culture ... be involved in O2 supply and, possibly, the hypoxia tolerance of Drosophila However, the globin might also be instrumental in alleviating oxidative stress by detoxifying h...

Ngày tải lên: 30/03/2014, 02:20