Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2 011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...
Ngày tải lên: 10/09/2015, 08:27
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2
... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B Through RNA interference of SKP1, a component of an ubiquitin ligase ... Role of Med21/hSrb7 in the Regulation of HSP70B 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal...
Ngày tải lên: 10/09/2015, 08:27
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 3
... as the link between the methylation of histone H3 residues lysine 34 and lysine 79 (H3K34 and H3K79) and the ubiquitination of histone H2B, abrogating the methylation of H3 while leaving the ubiquitinated ... 2005) 1 .3. 4 E4 Ubiquitin Ligases in the Elongation of Polyubiquitin Chains While the E3 ubiquitin ligases mediate the initial ubiquitination of the s...
Ngày tải lên: 10/09/2015, 08:28
Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... coronal section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the ... binding is reduced, indicating that HSF4 facilitates HSF1 binding via chromatin remodelling Heat shock genes are not HSF4 targets, but HSF4 regulates a set of nonclassical h...
Ngày tải lên: 18/02/2014, 04:20
Báo cáo sinh học: " A DNA vaccine against tuberculosis based on the 65 kDa heat-shock protein differentially activates human macrophages and dendritic cells" pot
... DNA- HSP65 Activation of the innate immune response mediated by DNA- HSP65 (A) Expression of costimulatory molecules and HLA-DR on the surface of macrophages (Mφ) and DC stimulated with DNA vaccine ... monocyte-derived macrophages and DCs Figure Phenotypic characterization of monocyte-derived macrophages and DCs (A) Expression of markers CD11b (Mac1), CD86 and HLA-...
Ngày tải lên: 14/08/2014, 19:22
Immunomodulatory roles of heat shock proteins
... in the absence of OVA (No), or in the presence of 50 µg/mL OVA (ova), 50 µg/mL of OVA plus 5-200 µg/mL of respective heat shock proteins (Hsp/ova), 50 µg/mL of OVA plus 100 µg/mL of lactorferrin ... absence of OVA (No), or in the presence of 50 µg/mL OVA (ova), 50 µg/mL of OVA plus 5-200 µg/mL of respective heat shock proteins and 20 µg/mL PMB(Hsp/ova) , 50 µg/...
Ngày tải lên: 09/10/2015, 11:06
Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... Fig ATP-binding domain of HSP70 is essential for the inhibition of H2O2-induced activation of caspases-9 and -3 and apoptosis (A) The effects of HSP70 and its deletion mutant proteins on the ... activation Such a mechanism is independent of the interaction of HSP70 with Smac but requires the ATP-binding domain of the protein However,...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot
... vertebrates In conclusion, there is a single, large, evolutionarily conserved protrusion on the surface of the catalytic domain of PCSK9 The lack of other residue conservation on the PCSK9 surface ... of the mutants S15 3A -PCSK9, Q19 0A -PCSK9, R19 4A -PCSK9, D20 4A -PCSK9, K22 2A -PCSK9, R23 7A -PCSK9, D23 8A -PCSK9, D37 4A -PCSK9, C37 5A -PCSK9, S37...
Ngày tải lên: 23/03/2014, 07:20
Report on the Regulation of Reproductive Cell Donation in the European Union potx
... out the findings on the principles of confidentiality, anonymity and non-remuneration in the donation of reproductive cells, as well as donor compensation, consent for egg cell donations and the ... donor offers the cells exclusively for the use of the recipient specified in the declaration of donation; c) the declaration of donation includes – beyon...
Ngày tải lên: 28/03/2014, 16:20
Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response" ppt
... is in accordance with the highly increased cytokine and chemokine secretion induced by poly(I:C) and emphasizes the strong proinflammatory impact of the TLR3 ligand poly(I:C) for SAEC Regulation ... expression of other TLRs and proteins involved in TLR signaling in SAEC In addition, we demonstrate that the expression of TLRs and their signaling p...
Ngày tải lên: 11/08/2014, 08:21
báo cáo khoa học: " The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro" ppsx
... explain the missing regeneration potential of BONJs In contrast, the non-nitrogen-containing bisphosphonate clodronate did not have any significant impact on osteoblasts cyclin D1 gene expression ... Effect of bisphosphonates on collagen gene expression The collagen gene expression was stimulated to the most extent by ibandronate, reaching a maximum of...
Ngày tải lên: 11/08/2014, 20:20
Investigations on the immunopathology of enterovirus 71 1
... of EV 71 strains 18 4 CHAPTER CONCLUSION AND FUTURE WORK 19 2 7 .1 ROLE OF INTERLEUKIN-6 IN THE IMMUNOPATHOGENESIS OF EV 71 INFECTION 19 2 7.2 ROLE OF DC IN EV 71 INFECTION ... Distribution of EV 71 isolates identified globally from 19 70 to 2000 16 Figure 1. 4 Distribution of inflammation in brain sections of EV 71 patients 23 Figure 1. 5 The postulated pathol...
Ngày tải lên: 09/09/2015, 10:21
Investigations on the immunopathology of enterovirus 71 3
... percentage composition per spleen The dotted line indicates the highest amount or percentage of cells observed for the two fatal strains (B) Specific anti-EV71 IgM and IgG titers in sera of infected ... CHAPTER INVESTIGATIONS ON EV71 VIRULENT DETERMINANTS B Figure 6.5 Adaptive immune response in EV71-infected AG129 mice (A) Two-week-old mice were infected ... (n=5) were euthaniz...
Ngày tải lên: 09/09/2015, 10:21
Investigations on the immunopathology of enterovirus 71 2
... well as the effects of the systemic inflammatory response on the vascular endothelium The key to further decipher the exact mechanisms for PE in EV71 encephalitis relies on the development of more ... observed (Shieh et al, 20 01; Yang et al, 20 09) 22 CHAPTER LITERATURE REVIEW Figure 1.4 Distribution of inflammation in brain sections of EV71 patients (A) Whole brai...
Ngày tải lên: 09/09/2015, 10:21