Regulation of t cell clonal expansion
Regulation of t cell clonal expansion
... with IL-2 to stimulate the T cells Their findings have important implications in the study of T cell clonal expansion It demonstrates that intrinsic control mechanisms that regulate T cell expansion ... the understanding of the regulation of T cell clonal expansion is of particular importance: (1) To generate T cells of a particular effector function The...
Ngày tải lên: 09/09/2015, 18:56
Báo cáo y học: " Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival" pptx
... expressed p30 on susceptibility of cells to apoptosis independent of other viral proteins p30 was transiently expressed in Jurkat T- cells and 29 2T cells and tested for susceptibility to apoptotic stimuli ... and monitored for their progression through the cell cycle by flow cytometry At h after release, cells started to enter the G2/ M phase of cell cycle in both...
Ngày tải lên: 13/08/2014, 05:22
Tài liệu Regulation of cancer cell metabolism docx
... effect Only on closer examination of the full metabolic requirements of a cancer cell was the advantage of PKM2 expression revealed A cancer cell, like any normal cell, must obtain the building ... Senescence • Cell death ROS level • Proliferation • Cell survival Cancer cell • Metabolism • Protein translation Antioxidants Nature effect of Figure | relationship betwee...
Ngày tải lên: 15/02/2014, 04:20
Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
... peptides from rat CD2 may bind to human CD58 Human -CD2 and rat -CD2 have high 3D structure similarity Comparison of 3D structures of hCD2 from CD2 CD58 complex [30] and the structure of rat CD2 [36] using ... biological activity and to study the effect of reducing the chain length of peptides on Ó FEBS 2004 Design of peptides for T-cell adhesion...
Ngày tải lên: 19/02/2014, 13:20
Report on the Regulation of Reproductive Cell Donation in the European Union potx
... out the findings on the principles of confidentiality, anonymity and non-remuneration in the donation of reproductive cells, as well as donor compensation, consent for egg cell donations and the ... donor offers the cells exclusively for the use of the recipient specified in the declaration of donation; c) the declaration of donation includes – beyon...
Ngày tải lên: 28/03/2014, 16:20
báo cáo hóa học:" Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients" potx
... Rowland-Jones SJ, Bodmer HC, McMichael AJ, Bell JI: Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA -A2 and influenza A matrix peptide Proc Natl ... have been involved in drafting and critically revising the manuscript LI conceived and coordinated the study and draft the manuscript All authors read and approved t...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: " Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients" docx
... as: Ochsenreither et al., Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients Journal of Translational Medicine 2010, 8:35 ... size of tissue samples as we used for comparing tissue with blood samples (48 vs 42 instead of 24 vs 18) Regarding the repertoire restriction in blood (healthy vs...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf
... rationale for safety Further, it is clear that safety with an antibody is not the same as safety with a T cell; antibody studies therefore cannot substitute for directed designer T cell trials via ... against the most intensive Strategies for untested antigen targets If by an early Strategy, the patient can safely be treated, then one may reasonably advance to more potent St...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo y học: " Chitosan Interferon-c Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune Responses" pps
... altering cytokine production of a CD8+ T -cell subpopulation and by decreasing the antigenpresenting activity of dendritic cells Figure Effect of chitosan interferonc nanogene (CIN) therapy on the dendritic ... identified by intracellular cytokine staining and counted by flow cytometry after gating for tetramer-labelled cells C, Apoptosis of OVA-specific CD8+ T cell...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation" pdf
... the T-cell repertoire is capable of responding to virtually any foreign organism In spite of its structural diversity, however, the repertoire of functional TCR is still greatly outnumbered by ... generation of ‘new’ naive T cells by autoproliferation is under selective pressure and ultimately leads to TCR diversity contraction Studies on the impact of age on the reper...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
... differentiate into Th1 and Th2 cells, which secrete distinct sets of cytokines Studies on CTLA-4 expression of differentiated Th1 and Th2 cells have been performed mostly in Th1 and Th2 long-term T cell ... immunopathology Controlled T cell activation by CD28 and CTLA-4 CD28 and CTLA-4 have distinct functions during T cell activation Triggering of CD28 en...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
... versa) may contribute to the acceleration of disease onset in AA upon preventive treatment with RIB5/2 The differential clinical efficacy of anti-CD4 mAbs is not restricted to arthritis but is also ... acceleration of the onset of AA after pretreatment with the mAb RIB5/2 This finding may be important for the understanding of pathogenesis in arthritis despite pre...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... anti-IL-1 therapy AntiIL-17 cytokine therapy might be an interesting new antirheumatic approach that could contribute to the prevention of joint destruction as an adjunct to anti-TNF and anti-IL-1 therapy ... together regulate interleukin-17- induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin" pptx
... nonsteroidal antirheumatic drug; RA, rheumatoid arthritis; RF, rheumatoid factor Results Patient characteristics Baseline characteristics of patients with early inflammatory arthritis of non-crystal origin ... patients with early inflammatory arthritis who groups develop rheumatoid arthritis (RA) from (a, b) all other early inflammatory arthritis patients (early disease tha...
Ngày tải lên: 09/08/2014, 06:22