Activity based chemical proteomics profiling of natural products and drug like small molecules

... describe the design and synthesis of OrlistatTM -like natural product -based probes (Chapter 2, & 4), K11777 -like drug candidate -based probes (Chapter 5) and azanitrile-containing small molecules (Chapter ... 1.2 Activity- Based Protein Profiling (ABPP) 1.2.1 Introduction 1.2.2 Activity- Based Probe Design 1.2.3 Bioorthogonal Chemistry in ABPP 10 1.2.4 Application...

Ngày tải lên: 09/09/2015, 18:54

... SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURAL PRODUCTS AND THEIR ANALOGS AS NEW CANCER CHEMOTHERAPEUTIC AGENTS FANG ZHANXIONG (B.Sc.(Hons.) NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... production of a large number of analogs with the basic template.56 Epothilone D has shown to be at least as cytotoxic as paclitaxel against a range of...

Ngày tải lên: 10/09/2015, 15:49

... overview of catabolic pathways Metabolism of fatty acids Metabolism of glucose (glycolysis) Conversion of pyruvate to acetyl coenzyme A Anabolism of fatty acids from CH3COSCoA Anabolism of glucose ... Biogenesis of phenols through shikimic acid Biosynthesis of shikimic acid O COO OH + PO PO O OP COO O HO OH OH OH COO HO COO -H2O O OH OH NADPH shikimic acid OH HO OH Biosynthesi...

Ngày tải lên: 18/03/2014, 20:20

... unbiased and specific drug target profiling Using this method, a spectrum of specific targets of Andrographolide (Andro) was identified, revealing the mechanism of action of the drug and its potential ... anti-inflammation and anti-cancer effects, in live cancer cells We identified a spectrum of specific targets of Andro, which furthered our understanding of the mech...

Ngày tải lên: 10/09/2015, 09:26

... overview of applications of high- throughput technologies in chemical proteomics Much attention will be focused on studies of high- throughput strategies for proteomic profiling of aspartic proteases ... Objectives The aim of this thesis is to develop high- throughput amenable strategies for chemically profiling of aspartic proteases as well as protei...

Ngày tải lên: 10/09/2015, 15:49

... effective components in natural products Hence, the major aim of this thesis is to expand the analytical applicability of CE in the analysis of natural products The range of natural products is quite ... The migration of cations results in the migration of whole buffer solution through the capillary; this migration is the EOF Since the drivin...

Ngày tải lên: 11/09/2015, 14:27

... 1.2 Natural Products 1.3 Biosynthesis of Natural Products 1.4 Natural Products in Modern Drug Discovery Chapter Chemistry of Calophyllum wallichianum 12 14 2.1 Introduction 14 2.2 Results and ... general background of natural products chemistry Chapter two to chapter four concern the chemical studies of three plants: Calophyllum wallichianum, Scapania und...

Ngày tải lên: 03/10/2015, 20:33

Ngày tải lên: 18/02/2014, 11:20

... of any theory as to the nature of matter, or the nature of mind They are as true upon the theory that mind acts on matter—though separate and altogether different from it—as upon the theory of ... gives the readers of the journal the sort of words and the sort of thoughts they are used to so, on a larger scale, the writers of an age, without th...

Ngày tải lên: 06/03/2014, 13:20

... sands, gilsonite, and oil shale Imports Receipts of crude oil and petroleum products into the 50 States and the District of Columbia from foreign countries, Puerto Rico, the Virgin Islands, and ... applications and the production of consumer goods Exports Shipments of crude oil and petroleum products from the 50 States and the District of Columbia to foreign co...

Ngày tải lên: 23/03/2014, 10:20

... 35 Asynchronous Approvals of GM Products and the Codex Annex: What Low Level Presence Policy for Vietnam? Appendix Text of The Codex Annex ANNEX 3: FOOD SAFETY ASSESSMENT IN SITUATIONS OF LOW- LEVEL ... (2004) also reports the unofficial use of other GM crops- maize, soybeans and rice Asynchronous Approvals of GM Products and the...

Ngày tải lên: 26/03/2014, 14:08

... detected in this study The most notable findings were increased < /b> percentage < /b> with < /b> an absolute numbers of < /b> NK and < /b> B cells while reduced percentage < /b> with < /b> an absolute numbers of < /b> CD4 + lymphocytes in the peripheral ... the comparison of < /b> the absolute number < /b> of < /b> various peripheral blood lymphocyte subsets...

Ngày tải lên: 29/03/2014, 03:20

... to the system comprising the nanotip, the nanowire, and the emitter In the second stage, the ‘signal’ field containing one photon resonant with the transition jgi ! je2 i propagates along the nanowire ... photon storage, the ‘gate’ photon propagating along the nanotip is on resonant with the transition jgi ! je1 i and the frequency xL of the control field X(t...

Ngày tải lên: 22/06/2014, 01:20

... peacebuilding: The role of natural resources and the environment Conflict cycle Role of natural resources and the environment Recommendations Root causes Natural resources play a role in at least ... stability “Environmental security” refers to the area of research and practice that addresses the linkages among the environment, natural res...

Ngày tải lên: 28/06/2014, 19:20

... between topology of order complexes and commutative algebra in [8], Bj¨rner and Welker introduced the notion of Rees product of posets, which o is a combinatorial analog of the Rees construction ... Introduction and statement of main results 2 Preliminaries Rees products with trees 10 The tree lemma 16 Corollaries 20 Type BC-analogs 22 Introduction and statement of m...

Ngày tải lên: 08/08/2014, 01:20