Identification of a new tumor suppressor pathway modulating

Identification of a new tumor suppressor pathway modulating rapamycin sensitivity in colorectal cancer

... 3' ATGGAGGAGGACATTGATACC 3' ACATTGTATTCACCCCTACG 3' ATACGCCAGTGACGACCAGAGC 3' TAGCCCACACCATGAAAGCG 3' ATGGGAAGGTGAAGGTCGG 3' AAGACGCCAGTGGACTCCACGA 3' GTGGGGCGCCCCAGGCACCA 3' CTCCTTAATGTCACGCACGATTTC ... 3' AGTGGGCTGCGCGTCTCATTTTC 3' AAGGGTTCGTGGAGCATGGG 3' ATGGTTGCAACTGGCAGTTTG 3' AGGACCTTTGAGCAACCAAG 3' AACGGCAGCGCCTTCTTGCT 3' GGCCCATGACCAGATCAGCA 3' ATGAGCTGCACCAGAATGATCC 3' TTGGTTGTGTGAGC...

Ngày tải lên : 09/09/2015, 18:52

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Báo cáo y học: "Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site" doc

... physiologically relevant extract of matrix proteins MMP-13 degrades biglycan and decorin Biglycan in human normal and OA cartilage migrated as a doublet at 48 and 45 kDa, representing intact and ... identify the amino-terminus of all fragments Sequence analysis of the biglycan fragments generated by MMP-13 treatment revealed a novel major fragment of 28 kDa This fragment...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx

... participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... suppressor genes could be methylated in lung cell lines and tumors Next, we determined whether the methylation status of such genes could contribute for lung...

Ngày tải lên : 18/06/2014, 16:20

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Báo cáo y học: " Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase" doc

... drugs and/ or they can act as compensatory mutations by improving the viral replication capacity (RC) Alternatively, they can appear as a result of escape from immunological pressure on wild type amino ... mechanisms explain the appearance of the E40F and K43E substitutions during NRTI-treatment by generating a panel of site directed mutants and analysing their replication ca...

Ngày tải lên : 13/08/2014, 06:20

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Acceptability, safety and contraceptive efficacy of a new single rod subdermal 3 ketodesogestrel implant in singaporean women acceptors

... Biotransformation and pharmacokinetics of desogestrel / 3- ketodesogestrel (d) Drug safety (e) Clinical data Synopsis IMPLANON™ is a new single- rod subdermal contraceptive implant containing a relatively ... fetal development, labour and delivery, lactation, neonatal viability and growth of the newborn (perinatal and postnatal studies) In the teratologic, pe...

Ngày tải lên : 15/09/2015, 21:09

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Báo cáo y học: "Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring" doc

... therapeutics for prostate cancer candidate predictor of efficacy in both prostate and breast cancer Finally, the observed sensitivity to dasatinib of prostate cancer cell lines with expression of basal ... targets, including Abl, c-kit and PDGFR kinases, showed minimal efficacy in early clinical testing with a small number of patients [19,20] Identification of...

Ngày tải lên : 14/08/2014, 08:20

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Báo cáo khoa học: Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7 doc

... importance as the guardian of the cell cycle and its clinical relevance in human cancers, structural and thermodynamic understanding of the mechanisms of action of the Rb protein is far behind that of ... denote the position of FITC moieties (B) Association of E7( 1-40) and RbAB at 200 nM E7( 1-40) (C) Association of E7( 1-40) and the RbAB domain at...

Ngày tải lên : 22/03/2014, 21:20

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báo cáo hóa học:" Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies" docx

... MOVCAR-9 MOVCAR-10 MOVCAR-1 MOVCAR-2 MOVCAR-9 MOVCAR-10 Figure Extra -and intracellular Muc16 expression by MOVCAR cells Extra -and intracellular Muc16 expression by MOVCAR cells (A) MOVCAR-10 cells ... cDNA was prepared cDNA was amplified with the following primer pairs from Integrated DNA Technologies: Muc16 5'-TGCCACCTACCAGTTGAAAG-3' and 5'-GTACCGCCAAGCAGATGAG-3'; GAPDH 5'-...

Ngày tải lên : 20/06/2014, 07:20

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Báo cáo khoa học: "Identification and characterization of a new E3 ubiquitin ligase in white spot syndrome virus involved in virus latency" pot

... signaling pathways involved in latency regulation [25] As a RINGcontaining E3 ubiquitin ligase, WSSV403 is able to interact with its substrates besides E2 conjugating enzymes and to mediate degradation ... used, 403RING can be strongly activated as an E3 ligase by Pvubc, ubcH3, ubcH 5a, ubcH5c and ubcH6 (Fig 2B), indicating that 403RING can support E3 ligase activity a...

Ngày tải lên : 12/08/2014, 04:21

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Roles of siRNAs and miRNAs in host responses to virus infection identification and characterization of a novel viral suppressor of RNA silencing

... demonstrated as a natural antiviral defense in plants Is RNAi also antiviral in animals? Flock house virus (FHV), which can infect both animals and plants, was demonstrated as both an initiator and a ... biogenesis and possible roles of miRNAs and siRNAs 1.3.8 Viral suppressor and miRNA-controlled developmental pathway interaction After discovering miRNAs in...

Ngày tải lên : 16/09/2015, 17:11

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Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"

... Implementation of a new emergency medical communication centre organization in Finland - an evaluation, with performance indicators Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2011 ... medical call centre organization reform in Finland Material and methods A retrospective observational study was conducted in the EMCC in...

Ngày tải lên : 25/10/2012, 10:02

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Tài liệu Báo cáo khoa học: Identiﬁcation, sequencing, and localization of a new carbonic anhydrase transcript from the hydrothermal vent tubeworm Riftia pachyptila docx

... 757–778 AAG AGC GCA ACT GAT AGT GCA TCC GCC ATC GAC GCA ATT AGC CTT GCT AGC AGT ACG AGG 613–630 822–839 706–723 466–483 AAG AGC AAA GAT GAT AGT GAT TAC GCC ATC CCA CAG ATT AGC ATC AAT AGC AGT CAG ... The fact that several genes can be the source of several isoforms in the branchial plume could increase global carbonic anhydrase activity Carbonic anhydrase transcripts in Rifti...

Ngày tải lên : 18/02/2014, 16:20

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Tài liệu Báo cáo khoa học: Development of a new method for isolation and long-term culture of organ-speciﬁc blood vascular and lymphatic endothelial cells of the mouse pdf

... GAGATGGATAAAGTTTTAAACAGAG-3¢ and LTA1R, 5¢-TGAAGGCAAATCTCTGGAC-3¢ for the former, and LTA–M2F, 5¢-CAGCTGTTTTGCTTGAATTATG-3¢ and LTA–2R, 5¢-GAATTCATTATGTTTCAGGTTCA GGGG-3¢ for the latter The PCR products ... functions and intracellular signaling Thus, our system provides an accessible method to examine the endothelial cell biology of the mouse, and will accelerat...

Ngày tải lên : 18/02/2014, 17:20

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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

... GAG AGG AAC TGA ACA GAA CAT TG 3¢ 5¢ CAA CTG CGT ATT AGT GAA GAA TG 3¢ 5¢ AAT CAA ATT TTA TTA TAA GAC C 3¢ 5¢ AAT AGC TAA TTA GAG ACC AT 3¢ using the 2400 (or 480) thermal cycler To estimate the ... CAA CAA TAT GC 3¢ 5¢ GTC CCA ACT TGA AAT CCT GAT C 3¢ 5¢ CAA GTT TAT AGT CTA CAC GTT GTA C 3¢ 5¢ CTT AGC ATC TTC CAT GGC TTG ATC 3¢ 5¢ ATA CAC ACA AAC TCA CAA GG 3¢ 5¢ CAA CAT ATT TTA AAT AAA...

Ngày tải lên : 22/02/2014, 04:20

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Báo cáo khoa học: Synthesis and characterization of a new and radiolabeled high-afﬁnity substrate for H+/peptide cotransporters pdf

... sub5910 strates of H+ ⁄ peptide cotransporters, such as Gly-Sar, Ala-Ala, Lys-Lys, Ala-Asp, d-Phe-Ala, Ala-Ala-Ala, d-aminolevulinic acid, cefadroxil and Ala-4-nitroanilide (all 100 lm, Table 1) ... UK) Dexamethasone, apotransferrin, Gly-Gln, AlaAla, Ala-Ala-Ala, Lys-Lys, d-aminolevulinic acid, cefadroxil, Gly, Pro-Ala, 8-aminooctanoic acid and Gly-Sar were from Sigma-Aldrich (Deisenho...

Ngày tải lên : 07/03/2014, 05:20

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