Pentanidium catalyzed enantioselective phase transfer reactions 4

... 128.1, 127.5, 115.0, 1 14. 8, 81 .4, 70.9, 44 .1, 40 .2, 27.9; LRMS (ESI) m/z 544 .1 (M + Na+), HRMS (ESI) m/z 544 .2258 ([M + Na+]), calc for [C34H32FNO3+Na+] 544 .2258; [α]29 = + 54. 5 (c D 1.26, CHCl3); ... 207 .4, 171.1, 169.9, 141 .2, 139 .4, 136.3, 130 .4, 128.8, 128.6, 128 .4, 128.2, 128.2, 128.0, 127.5, 126.7, 81.3, 70.8, 45 .3, 44 .6, 30.3, 27.9; LRMS (ESI) m/z 44 2.2 (M + H+),...

Ngày tải lên: 09/09/2015, 17:53

... 2003, 12 5, 513 9 14 Ooi, T.; Uematsu, Y.; Kameda, M.; Maruoka, K Angew Chem 2002, 11 4, 16 21; Angew Chem Int Ed 2002, 41, 15 51 15 Kitamura, M.; Shirakawa, S.; Maruoka, K.; Angew Chem 2005, 11 7, 15 73; ... chemistry Table Phase- transfer catalyzed asymmetric alkylation of glycinate Schiff base 15 Chapter 16 Chapter 17 Chapter 1. 3 Various Reactions Catalyzed by Phase-...

Ngày tải lên: 09/09/2015, 17:53

... achieved (Scheme 2. 2) 32 Chapter Scheme 2. 1 Highly enantioselective Michael reactions of with catalyst 11 Scheme 2. 2 Organic-soluble base BEMP in phase- transfer system In 20 02, Arai et al developed ... Am Chem Soc 20 08, 130, 4897-4905 11 (a)Kano, T.; Kumano, T.; Maruoka, K Org Lett 20 09, 11, 20 23 20 25 (b) Wang, Y.; Kumano, T.; Kano, T.; Maruoka, K Org Lett 20 09, 11,...

Ngày tải lên: 09/09/2015, 17:53

... yield (%)c ee (%)d 96 52 28 K2CO3 24 87 48 Cs2CO3 18 82 50 Cs2CO3(Sat.aq.) 40 77 43 Zn2CO3 120 - Ag2CO3 15 85 11 KF 24 91 46 CsF 18 88 60 a Na2CO3 NaOH 0.2 54 33 Reactions conducted using 0.01 ... the enolate anion Figure 3. 3 Proposed catalytic cycle in asymmetric α-amination of glycinate Schiff base by pentanidium 80a 3. 2 .3 Enantiomer enriment Pentanidium catalyzed enantiose...

Ngày tải lên: 09/09/2015, 17:53

... 141 142 143 144 1 45 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 1 65 166 167 168 169 170 171 172 173 174 1 75 176 177 178 179 180 181 182 183 184 1 85 186 187 Chiral ... -200 0.0 No 1.3 2 .5 Ret.Time 3.8 5. 0 Peak Name 6.3 7 .5 8.8 10.0 12.0 Area Rel.Area mAU Height mAU*min % 6 .51 n.a 1343.718 478.199 95. 32 7.24 n.a 65. 802 23.492 4.68 1409 .52 0 50...

Ngày tải lên: 09/09/2015, 17:53

... BICYCLIC GUANIDINE CATALYZED ENANTIOSELECTIVE ALLYLIC ADDITION REACTIONS WANG JIANMIN 2011 BICYCLIC GUANIDINE CATALYZED ENANTIOSELECTIVE ALLYLIC ADDITION REACTIONS WANG JIANMIN ... develop highly enantioselective allylic addition reactions catalyzed by chiral bicyclic guanidines A chiral bicyclic guanidine was found to catalyze a direct asymmetric...

Ngày tải lên: 12/09/2015, 09:07

... - 34. 8 IR (KBr) 7 74, 15 04, 3050 cm-1 HRMS (ESI) m/z 44 0.1 348 (M+H+), calc for C28H24ClNP 44 0.1335 The ee of 147 was determined by converting back to 146 using H2O2 4. 6 Protocol for guanidinium salt ... 127.2, 127.3, 127 .4, 127.6, 127.9, 128.0, 129.3, 129.6, 129.7, 130.3, 132.9, 133.0, 133.3, 133 .4, 133.9, 1 34. 0, 1 34. 1, 1 34. 2, 1 34. 3, 1 34. 6, 1 34. 7, 137.8, 139.9, 142...

Ngày tải lên: 14/09/2015, 08:38

... BICYCLIC GUANIDINE CATALYZED ENANTIOSELECTIVE ISOMERIZATION REACTIONS LIU HONGJUN 2010 BICYCLIC GUANIDINE CATALYZED ENANTIOSELECTIVE ISOMERIZATION REACTIONS LIU HONGJUN ... this study is to develop highly enantioselective isomerization reactions catalyzed by chiral bicyclic guanidines A chiral bicyclic guanidine was found to catalyze the isomerization o...

Ngày tải lên: 11/09/2015, 09:17

... 148 .7, 162.1 FTIR (film): 928, 1 045 , 1216, 142 5, 1520, 1 643 , 2977, 3020, 344 6 cm-1 LRMS (ESI) m/z 44 2.1 (M-H+), HRMS (ESI) m/z 44 2.0 044 (M-H+), calc for C17H14Cl2N3O5S 44 2.0037 The enantiomeric excess ... 28.2, 28 .4, 54. 0, 57.6, 83.5, 84. 7, 128.1, 129 .4, 130.3, 130.9, 133 .4, 137.2, 141 .7, 144 .3, 168.1, 169.1 FTIR (film): 758, 928, 1 045 , 1159, 1216, 1 349 , 142 4, 1522,...

Ngày tải lên: 11/09/2015, 10:05

... Chapter 2 Enantioselective Protonation Reactions Catalyzed by Chiral Bicyclic Guanidine Enantioselective Protonation Reactions Catalyzed by Chiral Bicyclic Guanidine 2.1 Catalytic Enantioselective Protonation Reactions ... List of Abbreviations  Chapter 1 Chiral Guanidines Catalyzed Enantioselective Reactions Chiral Guanidines Catalyzed Enantioselective Reactions 1  1.1 Introduction  2  1.2...

Ngày tải lên: 12/09/2015, 10:17

... Ph2CH 90 R /S 3 :1 86 :1 5 :1 55 :1 12 :1 54 :1 Scheme 1. 11 Ebetino’s asymmetric Michael addition of phosphinic and aminophosphinic acid An asymmetric Michael addition of phosphinic and aminophosphinic ... Adv Synth Catal 2004, 346, 10 35 10 50 Hiratake, J.; Oda, J., Biosci Biotech Biochem 19 97, 61, 211 – 218 Pietrusiewicz, K M.; Zablocka, M., Chem Rev 19 94, 94, 13 75 14 11...

Ngày tải lên: 14/09/2015, 08:38

... CH2 Cl2 , -20 o C O 93a 122 H S O N O Ph 124 80% yield, 99% ee OH O OH OH R1 R2 122 MeOC O R2 124 OH H CO2 Me 124 a 92% yield 98% ee OH PhOC OH 114a (10 mol%) CH 2Cl2, -20 oC OH O O OH H CO2 Et ... (99%) 103d : R1=Ph; R 2= CN (97%) 103e : R 1=Ph; R2 =COPh (80%) 102a : R 1=R 2= CN 102b: R1=R2 =CO 2Me 102c: R 1=R 2= COPh 102d : R1=Ph; R 2= CN 102e : R 1=Ph; R2 =COPh O O Ph2 P(O)H TBD Ph Ph...

Ngày tải lên: 14/09/2015, 08:38

... Chapter 181a 56 30 ; 25 136 b [2-NpCH2] 181b 37 35 ; 15 136 c [3, 5-MeOC6H4CH2] 181c 58 32 ; 20 136 d [3- NO2C6H4CH2] 181d 58 36 ; 14 136 e [Et] 181e 45 38 ; 18 a 136 a [Bn] 136 f [i-Bu] 181f 48 56; 32 donor : ... 1:11 tBu F3 C F3C H N H N Ph Ph NH Ph CF3 CF3 BAr F-4 = B HN 2BAr F-4 Ph F3C CF3 F3 C 148 CF3 Scheme 3. 1 Göbel’s chiral bis(amidinium) salt 148 catalyzed Diels-Alder re...

Ngày tải lên: 14/09/2015, 08:38

... ee%b Entry R 4- NO2 Me 56a 10 90 50 2c 4- NO2 Me 56a 12 89 54 3d 4- NO2 n Bu 56b 14 50 41 4- NO2 Bn 56c 89 48 3-NO2 Bn 56d 73 47 2-NO2 Bn 56e 72 14 4-CN Bn 56f 63 48 2-Cl-5-NO2 Bn 56g 82 31 a Isolated ... 2002, 1 14, 46 89 -46 92; Angew Chem Int Ed., 2002, 41 , 45 07 -45 10 (d) M Shi and J.-K Jiang, Tetrahedron: Asymmetry, 2002, 13, 1 941 -1 947 (e) M Shi, Y.-M Xu and Y.-L Shi,...

Ngày tải lên: 14/09/2015, 14:12

... pendant 24H éventuellement • Exposition l’air rapide = tannage de la peau • Évolution: – Guérison sans séquelle en jours Deuxième degré superficiel • Flammazine en couche épaisse • Hydrocolloïde en ... Pansements : objectifs – Indolores (traitement antalgique adapté) – Atraumatiques (pansement non adhérent) – Antiseptiques incolores Premier degré • Crèmes hydradantes neutres • Flammazin...

Ngày tải lên: 18/06/2014, 10:44