Structure basis for molecular recognition of folic acid by folate receptor

... form of folate in circulation is 5-methyl tetrahydrofolate (5-methyl THF) [7] a) b) Figure Chemical structure of folic acid and folate derivatives a) Constitution of folic acid b) Tetrahydrofolate ... crystal structure of FRα -folic acid complex which provided the molecular basis for the high affinity binding Folate receptor is a globular protein which con...

Ngày tải lên: 09/09/2015, 11:28

... control at t ¼ for each peptide The percentage of degradation was calculated by comparing the area of the peaks of the intact peptide at t ¼ and t ¼ 60 Binding assays Binding assays were carried ... [33], the peptides containing a b-amino acid substitution in position have increased stability compared to the corresponding a- amino -acid- containing peptides...

Ngày tải lên: 08/03/2014, 08:20

... further oligosaccharides that are fragments of NA2F The structural information is complemented by thermodynamic parameters of binding determined by means of isothermal titration calorimetry for ... second conformation of the side chain of Glu221, which also adopts two conformations but not correlated with the anomeric form of the bound mannose is shown in dark gr...

Ngày tải lên: 23/03/2014, 11:20

... chain and had closer contacts with the CB atom of Ala82 in PRV8 2A than observed for Val in the ˚ PR The CE atom of P3¢ Arg moved  1.2 A and formed closer interactions with the CB atom of Ala82 All ... and inactive mutant V8 2A D25N with patients [8–10] We have reported crystal structures of PR, single mutants in complex with substrate analogs CA-p2...

Ngày tải lên: 30/03/2014, 20:20

... dehydratase Specificities of reactivating factors in the complex formation with dehydratases DDR and GDR form a complex with apoenzymes of diol and glycerol dehydratases, respectively, and transient formation ... dehydratase by DDR and of glycerol by dehydratase by GDR were 82% and 25% for diol and glycerol dehydratases, respectively studied similarly us...

Ngày tải lên: 16/03/2014, 05:20

... suitable for the holistic recognition of expressions from static facial images In the development, two new types of basis functions, namely, the Differentially Weighted Radial Basis Function ... Distribution of CSR for each basis function in the CBF network 143 6.10 The overall recognition rate for two criteria of Discriminative Indices vs number of C...

Ngày tải lên: 16/09/2015, 17:11

... Rev Mol Diagn 6(2), (2006) Multicolor quantum dots for molecular diagnostics www future-drugs.com 1.2 Time (min) quantum dots 15 10 20 25 30 35 Intensity (au) Quantum dots 0.8 0.6 0.4 0.2 Texas ... suited for monitoring biological systems for long periods of time, which is important for developing robust sensors for cancer assays and for in vivo imaging A fur...

Ngày tải lên: 15/02/2014, 05:20

... sugar-binding proteins should be defined in terms not of the affinities for sugars but of whether the protein adopts the open form or the closed form TvuCMBP–c-CD complex is seen as the closed form (Fig ... sugar-binding protein family was found to be located upstream of the TVA II gene, and the affinities of this protein for c-CD were higher than that for maltose [7] The results sug...

Ngày tải lên: 19/02/2014, 00:20

... Stereoview of the RMD monomer The cofactor-binding domain and the substratebinding domain are shown in aqua and light sand, respectively; the APPR portion of the cofactor (dark gray) and the ligand ... disease and reduced lung function [20] An eight-gene cluster encodes functions for synthesis and export of A-band O polysaccharide [21,22], and contains genes...

Ngày tải lên: 16/03/2014, 01:20

... structure) for cocrystallization of E chrysanthemi GH30 xylanase Fig S2 Dynamic light scattering profile of E chrysanthemi GH30 xylanase Fig S3 Examples of distinct habits of E chrysanthemi GH30 xylanase ... three-dimensional structure of the E chrysanthemi GH30 enzyme [16], together with its established mode of action [14], allowed us to present a hypothesis for the basis...

Ngày tải lên: 22/03/2014, 16:20

... (2005) A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis ... further specific ligand- binding information The ligandbinding data for some mutants, such as W17 6A and L172I, showed an increase that was clearly be...

Ngày tải lên: 23/03/2014, 07:20

... (1992) "A computational approach to style in language." Manuscript submitted for publication Halliday, Michael (1985) An introduction to functional grammar Edward Arnold Halliday, Michael and Hasan, ... example of verbal ellipsis, as in (2) (5) that constitute a sentence These variations at the abstract-element level of the grammar axe mirrored at the level of stylistic goals by...

Ngày tải lên: 23/03/2014, 20:20

... 5'UTR RNAs than for the population of EeRNAs, causing relative under-estimation of true envelope RNA concentration1 Nonetheless, as 5'UTR HCV RNA concentrations will be proportional to EeRNA concentration, ... infection [16,17], further undermines the potency of "immune control" and suggests, at least for patients with HCV, the definition of "control" may need to broadened...

Ngày tải lên: 19/06/2014, 08:20

... population of EeRNAs, causing relative under-estimation of true envelope RNA concentration1 Nonetheless, as 5'UTR HCV RNA concentrations will be proportional to EeRNA concentration, the question remains; ... mechanism for immune responses independent of any viral factor (given levels of virus are greater before immune recognition than afterwards the trigger for immune...

Ngày tải lên: 20/06/2014, 04:20