Characterization of the cellular response to hypoxia

... independent of mitochondrial ATP synthesis Figure 20 The dynamic regulation of mTORC1 upon reoxygenation is independent of mitochondrial ATP synthesis Figure 21 The dynamic regulation of mTORC1 in hypoxia ... comparable effect on mTORC1 activities in all cell lines Taken together, these results strongly suggest REDD1 does not play a role as the key mediator of the rapid r...

Ngày tải lên: 09/09/2015, 11:17

... & Therapy Vol No Luikart et al 20 Fujikawa Y, Sabokbar A, Neale S, Athanasou NA: Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis Ann ... the arthritis Of the many mediators of inflammation, mactinin is the first example of a fragment of a cytoskeletal component that might be released during leukocyte influx into...

Ngày tải lên: 09/08/2014, 01:23

... determined by intracellular (IC) staining of lines PMA (phorbol 12-myristate 13-acetate)/ionomycin activated T cells (a) We detected interferon (IFN)-γ staining but no interleukin (IL)-4 staining ... of a more generalised immune reactivity to extracellular matrix proteins in SSc Laminin and, less often, type IV collagen can induce proliferation of SSc lymphocytes [16] Autoanti...

Ngày tải lên: 09/08/2014, 08:22

... and the role of IHPCP The Indonesian response to the HIV/AIDS crisis among people who inject drugs is still modest There is a clear consensus among stakeholders of an urgent need to scale up the ... is to increase the number of drug users treated to more than 50,000 by 2010 These public health centres are targeting to reach another 23,000 peopl...

Ngày tải lên: 11/08/2014, 18:20

... likely to be referred for exercise testing for EIB Exercise testing to identify EIB in the laboratory is affected by the type of exercise, intensity and duration of exercise, inspired air conditions, ... appreciated the opportunity afforded by design of the protocol standardized for the intensity and duration of exercise, and the conditio...

Ngày tải lên: 12/08/2014, 11:22

... pivotal role of the UPR is to maintain ER homeostasis Therefore, the presence of mutated proteins that are unable to fold into their native conformation in the ER induces the UPR in an effort to restabilize ... expressed in tobacco protoplasts in the absence of a B chain [152] The degradation of ricin A chain is brefeldin A-insensitive and is inhibited by...

Ngày tải lên: 16/03/2014, 11:20

... ratio of the bronchodilatory response in COPD The impact of this issue on the interpretation of study results is best illustrated by considering the variability of a single dose level within and ... of the comparators included in this analysis The most striking feature of the plot is that the response to indacaterol at the plateau exceeds the r...

Ngày tải lên: 12/08/2014, 13:22

... Figure Cytokine response to chronic aspiration of gastric fluid Cytokine response to chronic aspiration of gastric fluid Cytokine levels were evaluated in the bronchoalveolar lavage (BAL) fluid ... model of chronic aspiration described herein, chronic aspiration can initiate an inflammatory response consisting of macrophages and T cells and characterized...

Ngày tải lên: 12/08/2014, 15:21

... dose-dependently to isolated recombinant CD11a and CD11b I domains The effective inhibition of binding of ICAM-4 positive red cells by anti -ICAM-4 antibodies, indicate a major role for ICAM-4 in binding of ... possible differences in binding of ICAM-4 and the other two ICAMs for the I domains Many of these mAbs displayed similar inhibitory profiles i...

Ngày tải lên: 20/02/2014, 11:20

... of parallel b strands associated to an antiparallel strand (b2) and is surrounded by helices (a1 , a2 , a3 , a7 and a8 ) The second domain consists of helices a4 , a5 and a6 all clustered on the top ... indicating that Rv1399c is composed of 22% of a- helices, 25% of b-strand and 39% of random coil The catalytic triad is located at the bottom of a s...

Ngày tải lên: 07/03/2014, 16:20

... very close to that of the mouse Muc4 (Table 1) The size of intron of the human MUC4 has been estimated to be  15 kb by restriction mapping [12] and to be at least 20 kb by our analysis of the human ... small mucin [26] The consensus sequence of the Muc4 tandem repeat is very close to that of SMC Nevertheless, the tandem repeat domain of Muc4...

Ngày tải lên: 08/03/2014, 23:20

... that mitochondria contribute to the induction of oxidative stress during ischemia ⁄ reperfusion in brain There is a growing body of information concerning the mechanism of ROS generation by the ... ADP inhibits opening of the mPTP by occupying binding sites located in the inner and outer mitochondrial membrane [39,40] The binding of ADP stabilizes...

Ngày tải lên: 16/03/2014, 22:20

... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...

Ngày tải lên: 30/03/2014, 03:20

... cytometry assay [16] Using the guidance for ligand binding assays [12] as a foundation in which to base the validation of a flow cytometry pharmacodynamic assay and applying the "appropriate" parameters ... dosed) individuals where assessed using the internalization assay The assay variability in the placebo data is 15.5% over the 113 days of...

Ngày tải lên: 18/06/2014, 15:20