Investigations on rab31s role in EGFR trafficking and neural progenitor cell differentiation towards astroglia

... pool containing Rab5 and its effector APPL1 (Adaptor protein, phosphotyrosine binding (PTB) 19    Introduction  domain, pleckstrin homology (PH) domain, leucine zipper-containing protein 1) is ... 87  The role of Rab31-interacting proteins in Rab31-mediated EGFR trafficking 89  5.1 Chapter Introduction: Potential Rab31-interacting proteins in an EGFRtrafficking complex ... GFAP-po...

Ngày tải lên: 09/09/2015, 11:17

... those in the cultures of human monocytes or HFC alone (b) Gel zymography detection of MMP-2 and MMP-9 in human CD14+ monocytes of normal control monocytes, in HFC, and in a co-culture of the ... expression on monocytes is possibly associated with the pathogenesis of RA and CD147 may play an important role in the cartilage and bone destruction of RA To confi...

Ngày tải lên: 09/08/2014, 06:23

... acidity, integrated pest management, double-cropping, and crop Livestock’s role in climate change and air pollution rotations including green manure and cover crops Increasing crop yields result in ... 2000) Overgrazing is the greatest cause of degradation of grasslands and the overriding humaninfluenced factor in determining their soil carbon Livestock’s role in...

Ngày tải lên: 17/02/2014, 10:20

... that the hypodermis of the body wall, which synthesizes components of the cuticle, may offer a useful target for studies into the mechanism of the development and molting process in the roundworms ... presence of increasing concentrations of inhibitors for 10 days, and the number of molting larvae was determined Molting was manifested by shedding of...

Ngày tải lên: 20/02/2014, 11:20

... postinfection, we observed a marked difference between the number of CFUs of the wild-type strain and that of the PMM56 mutant strain in lungs and in the spleen (Fig 7A) Indeed, both strains ... cell envelope of M tuberculosis and to virulence [3–6] Nevertheless, their precise molecular mechanisms of action are still unknown, and the specific roles of...

Ngày tải lên: 23/03/2014, 09:20

... Guidance on Responsible Business in Conflict-Affected and High-risk Areas: A Resource for Companies and Investors aims to assist companies in implementing responsible business practices in conflict-affected ... international laws and standards for guidance on financial transactions regarding interactions with groups listed on international ter...

Ngày tải lên: 29/03/2014, 19:20

... (TIRdomain-containing adapter-inducing interferon-b) joining the RIG-I/MDA5 pathway In the other pathway, TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1 These kinases ... increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5’-nucleotidase...

Ngày tải lên: 18/06/2014, 16:20

... of IL -1 signaling on microglial activation, on IL -1- mediated inflammatory responses following Aβ vaccination, and on Aβ deposition during normal aging, we used interleukin -1 receptor 1- knockout ... inflammatory responses following Aβ vaccination and on Aβ deposition during normal aging using interleukin -1 receptor 1- knockout (IL -1 R1-/-)...

Ngày tải lên: 19/06/2014, 22:20

... effects of the particle concentration, the material of the particles, and the geometry of the containing cavity on natural convection were investigated A systematic and definite deterioration of natural ... enhancement in metal nanoparticle suspensions Int Commun Heat Mass Transf 2008, 35:867-872 Pantzali MN, Kanaris AG, Antoniadis KD, Mouza AA, Paras SV: Effect of nanofluids...

Ngày tải lên: 21/06/2014, 03:20

... protein Kinesin light chain Kinesin heavy chain Microtubules Figure Schematic diagram of a kinesin- cargo complex The cargo vesicles are thought to be associated with kinesins through the interactions ... the defects of Drosophila kinesin mutants in axonal transport, suggesting that UNC-76 coordinates with kinesin to regulate cargo trafficking in axons [23] The similarity...

Ngày tải lên: 06/08/2014, 18:21

... repeats (ANK), a transactivation domain (TAD) and a PEST domain (P) TM, transmembrane domain (b,c) Two models for the roles of Ofut1 in Notch trafficking Each model is illustrated in a schematic ... (green) adapted from [19] The S2 cleavage site is indicated by an arrow The intracellular domain (NICD) contains various elements involved in transcriptional activation:...

Ngày tải lên: 06/08/2014, 18:21

... Results Activation of bone morphogenetic protein signaling in collagen-induced arthritis Activation of BMP signaling during the course of CIA was visualized at different time points by immunohistochemistry ... likely to be influenced by the decreased number of cells in the cartilage, due to chondrocyte cell death during collagen-induced arthritis Activation...

Ngày tải lên: 09/08/2014, 13:22

... Kawashima H, Hatanaka A, Hoshi K, Ikada Y, Tabata Y, Iwanaka T: An animal model study for tissue- engineered trachea fabricated from a biodegradable scaffold using chondrocytes to augment repair ... 82 Omori K, Tada Y, Suzuki T, Nomoto Y, Matsuzuka T, Kobayashi K, Nakamura T, Kanemaru S, Yamashita M, Asato R: Clinical application of in situ tissue engineering using a scaffol...

Ngày tải lên: 10/08/2014, 05:21

... second In the standard surgery group (Group II), after having created an equal injury, the injury was sutured using 6-0 polyglactin (vicryl) Then the air leakage and bleeding were controlled and the ... investigating the effect of Ankaferd Blood Stopper on air leakage in the lung In our study, we investigated the air leakage repressive effe...

Ngày tải lên: 10/08/2014, 09:23