CD137L signalling induces differentiation of primary acute myeloid leukemia cells

... signalling in monocytes 1.2.5 CD137L signalling in dendritic cells 1.2.6 CD137L signalling in B cells 1.2.7 1.3 CD137L biology CD137L signalling in T cells Influence of CD137L signalling on myelopoiesis ... 4.2.4 Utility of CD137-treated AML cells in immunotherapy 86 4.3 Transfer of CD137 to AML cells 89 4.4 CD137L signalling induces differentiation...

Ngày tải lên: 09/09/2015, 11:15

... Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells Journal of Translational ... DNR-insensitive CD34+ AML cell lines (KG1a and Kasumi-1) and in CD34+ primary AML samples We showed that curcumin selective...

Ngày tải lên: 18/06/2014, 19:20

... loading Results BPA induces dose dependent apoptosis in acute myeloid leukemia cells To understand the potential role of BPA in biological systems of leukemias we tested the action of BPA in three ... activity of these compounds [17,18] In the present manuscript, we decided to investigate the effects of different doses of BPA on acute myeloid l...

Ngày tải lên: 18/06/2014, 15:20

... represented in the AML samples Intra-individual analysis of the spot patterns showed a high correlation between the sample from peripheral blood and bone marrow (Table 2) On/off-phenomena of the identified ... Expression of the plasminogen activator inhibitor-2 (PAI2) was only found in patients E and F with the subtyp FAB M0 and M4, respectively T...

Ngày tải lên: 18/06/2014, 15:20

... provided the original work is properly cited Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways ArticleCategory : Research ... effect and molecular mechanism of HHV -6A inducing apoptosis in primary human fetal astrocytes (PHFAs) We found that HHV -6A induced apoptosis...

Ngày tải lên: 18/06/2014, 18:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... activation of Aur-A and induces monopolar spindle in NB4-R2 cells (A) VX-680 inhibited phosphorylation of AurA at Thr288 in NB4-R2 cel...

Ngày tải lên: 18/06/2014, 19:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In...

Ngày tải lên: 20/06/2014, 03:20

... checked by indirect enzyme-linked immunosorbent assay (ELISA), myeloma cells line SP2/0 (106) were fused with splenocytes (107) by the addition of 45% polyethylene glycol (PEG-4000) Hybridomas ... may detect the NPM-wt existing in the cytoplasm and cause false positives In this study, we analyzed the antigen epitope of NPM-mA protein and confirmed it may exist in the C-terminal...

Ngày tải lên: 08/08/2014, 18:21

... Takahashi: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications Journal of Hematology & Oncology 2011 4:13 Submit your next manuscript ... The compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and be...

Ngày tải lên: 10/08/2014, 21:23

... secondary AML blast DNA and compared to a pre-transplant DNA sample from the patient and to DNA from the donor Analysis of leukemia- prone polymorphic alleles (XPA A2 3G, XPD Lys751Gln, XRCC1 Arg399Gln, ... modified and FLAG [fludarabin, ARA-C, and granulocyte colony-stimulating factor (GCSF)] was started After 18 days the patient had hematopoietic recovery with 3% bla...

Ngày tải lên: 10/08/2014, 21:23

... A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome Guoqing Wei1,2, ... Efficacy of induction chemotherapy for patients with high-risk myelodysplastic syndrome (MDS) or MDS-transformed acute myeloid leukemia with CHG regimen and...

Ngày tải lên: 10/08/2014, 21:23

... number of col- Isolation of phage able to bind cells from leukemia patients Phage clones that bind to leukemia cells were isolated by incubating a library of M13 phage bearing mer peptides with ... (Vista, California) with a diversity of approximately × 107 Initial selection of phage specific for myeloid leukemia used cells from patients with CM...

Ngày tải lên: 10/08/2014, 22:20

... Neg Normal Normal Normal Aberrant Normal Normal Normal Normal Normal Normal Normal Normal Normal Aberrant Normal Normal Normal Aberrant Normal Normal Aberrant Normal Normal Aberrant Normal Normal ... Nil Normal Normal Normal Aberrant Normal Normal Normal Normal Normal Normal Aberrant Normal Aberrant Aberrant Normal Normal Normal Normal Normal Normal...

Ngày tải lên: 10/08/2014, 22:20