Investigations on the immunopathology of enterovirus 71 4
Investigations on the immunopathology of enterovirus 71 4
... CHAPTER CONCLUSION One limitation of the present study is the use of neonatal mice as animal model IL-6 functions mainly as the inducer of acute-phase response and T- and B-cell stimulation Given the ... throughout the course of infection While we could not entirely rule out the contribution of myositis to EV71-induced disease manifestations, our results suggest that th...
Investigations on the immunopathology of enterovirus 71 1
... of EV 71 strains 18 4 CHAPTER CONCLUSION AND FUTURE WORK 19 2 7 .1 ROLE OF INTERLEUKIN-6 IN THE IMMUNOPATHOGENESIS OF EV 71 INFECTION 19 2 7.2 ROLE OF DC IN EV 71 INFECTION ... Distribution of EV 71 isolates identified globally from 19 70 to 2000 16 Figure 1. 4 Distribution of inflammation in brain sections of EV 71 patients 23 Figure 1. 5 The postulated pathol...
Investigations on the immunopathology of enterovirus 71 3
... percentage composition per spleen The dotted line indicates the highest amount or percentage of cells observed for the two fatal strains (B) Specific anti-EV71 IgM and IgG titers in sera of infected ... CHAPTER INVESTIGATIONS ON EV71 VIRULENT DETERMINANTS B Figure 6.5 Adaptive immune response in EV71-infected AG129 mice (A) Two-week-old mice were infected ... (n=5) were euthaniz...
Investigations on the immunopathology of enterovirus 71 2
... well as the effects of the systemic inflammatory response on the vascular endothelium The key to further decipher the exact mechanisms for PE in EV71 encephalitis relies on the development of more ... observed (Shieh et al, 20 01; Yang et al, 20 09) 22 CHAPTER LITERATURE REVIEW Figure 1.4 Distribution of inflammation in brain sections of EV71 patients (A) Whole brai...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2 011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2
... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B Through RNA interference of SKP1, a component of an ubiquitin ligase ... Role of Med21/hSrb7 in the Regulation of HSP70B 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 3
... as the link between the methylation of histone H3 residues lysine 34 and lysine 79 (H3K34 and H3K79) and the ubiquitination of histone H2B, abrogating the methylation of H3 while leaving the ubiquitinated ... 2005) 1 .3. 4 E4 Ubiquitin Ligases in the Elongation of Polyubiquitin Chains While the E3 ubiquitin ligases mediate the initial ubiquitination of the s...
Investigations on the toxicity of nanoparticles
... + Oxidationm-n- 1.3 Equation 1.3 depends on the thermodynamics of the process, which in turn is represented by the electrochemical potentials of the corresponding half cell reactions These are ... stability of the particles Agglomeration of the nanoparticles will yield particles of size in the micron range, skewing data interpretation The commercially available...
Báo cáo khoa học: Biosynthesis of isoprenoids – studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase pdf
... above, these initial conditions were rapidly conducive to steady conditions where and were present in very similar concentrations, and the rates of the forward reaction (conversion of to 3) and the ... Discussion The main part of the present study was a search, under conditions of maximal stringency, for fragment exchange that could be the hallmark of the hypothetical...
Báo cáo khoa học: Amino acid residues on the surface of soybean 4-kDa peptide involved in the interaction with its binding protein potx
... mechanism of the interaction between the 4-kDa peptide and 43-kDa protein has the minimum components of insulin–insulin receptor interaction, the area consisting of Ile25, Val29, Phe31 and Ile33 in the ... Dissociation constants of the 4-kDa peptide variants To investigate the residues of the 4-kDa peptide involved in binding to the 43-kD...
Báo cáo khoa học: Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase pdf
... proteins in the purified DNA Fig Effect of heliquinomycin on DNA helicase activity (A) Top: effects of increasing concentrations of heliquinomycin (HQ) on the DNA helicase activities of the MCM4/6/7 ... (4/6/7) 440 kDa Fig Effect of increasing concentrations of heliquinomycin (HQ) on the formation of the MCM4/6/7 complex The MCM4/6/7 complex was...
Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot
... vertebrates In conclusion, there is a single, large, evolutionarily conserved protrusion on the surface of the catalytic domain of PCSK9 The lack of other residue conservation on the PCSK9 surface ... of the mutants S15 3A -PCSK9, Q19 0A -PCSK9, R19 4A -PCSK9, D20 4A -PCSK9, K22 2A -PCSK9, R23 7A -PCSK9, D23 8A -PCSK9, D37 4A -PCSK9, C37 5A -PCSK9, S37...
Báo cáo khoa học: Effect of the -Gly-3(S)-hydroxyprolyl-4(R)-hydroxyprolyltripeptide unit on the stability of collagen model peptides ppt
... modification in the Xaa position of -GlyXaa-Yaa- collagen- like peptides increases the stability of the triple-helical structure by a small margin Insertion of 3(S)Hyp in the context of the nine ... and the other peptides at low concentrations indicates the importance of 4(R)Hyp in the nucleation process Future studies will be performed to study the mechanism...
Báo cáo hóa học: " Research Article Impact of LQI-Based Routing Metrics on the Performance of a One-to-One Routing Protocol for IEEE 802.15.4 Multihop Networks" docx
... enable the calculation of the cost of a path, based on the LQI values of all links Therefore, we chose to evaluate the performance of these LQI-based routing metrics for NST-AODV Note that the PATH-DR ... data transmission rate for each node to allow for a link quality estimation [5] 4.5 MultiHopLQI One of the first attempts at a link quality estimat...