Efficient computational techniques for tag SNP selection, epistasis analysis, and genome wide association study

... problems in GWAS: tag SNP selection and SNP imputation Tag SNP selection aims at selecting a small number of SNPs (called tag SNPs) from a large number of SNPs using the non-random association (linkage ... GWAS: tag SNP selection and SNP imputation A novel algorithm called FastTagger is developed to reduce the number of tag SNPs and to improve efficiency FastTagger i...

Ngày tải lên: 09/09/2015, 10:06

... TDT FOR HUMAN QTL MAPPING AND GENOME- WIDE ASSOCIATION STUDY HAO YING (Master of Science, National University of Singapore ) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... 43 3.3 TDT for QTL mapping by ERS 48 3.4 The power of TDT with ERS 50 CONTENTS v TDT in Genome- wide Association Study 57 4.1 FDR-controlling ... logistic model for TDT 62 Gen...

Ngày tải lên: 11/09/2015, 16:06

... COMPUTATIONAL TECHNIQUES FOR SIMULATING THE INTERACTIONS BETWEEN PEPTIDES AND CARBON NANOTUBES CHENG YUAN (B S., FUDAN UNIVERSITY, CHINA) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... energy fitot the sum of inter-molecular forces and external forces F the force acting on the particle s s s Gcnt , G peptide , Gcomplex free energy of the peptide, the ca...

Ngày tải lên: 13/09/2015, 21:46

... linkers, amplification of targeted DNA, purification of amplified DNA, labeling, hybridization, and scanning The Affymetrix GeneChip® Human Mapping 500K Array was used Scanning and analysis were performed ... subsequently genotyped in patients with Behçet's disease and controls using a case-control genetic association approach and the TaqMan SNP Genotyping Assays (Applied Biosys...

Ngày tải lên: 09/08/2014, 14:20

... testing of smoking will result in public health improvements [18] and reduce the likelihood of harm; such harm could include a lowering of the motivation to quit or of the self-efficacy for quitting, ... patients [20] The coordinated effort of multidisciplinary research teams that address these complex issues will help inform the circumstances under which we can tr...

Ngày tải lên: 11/08/2014, 12:20

... of Genome- Wide Association Study for NBA in LW_2b 196 SI 4: Manhattan plot of Genome- Wide Association Study for NBA in LW_3 197 SI 5: Manhattan plot of Genome- Wide Association Study for ... Supplementary Information LIST OF SUPPLEMENTARY INFORMATION SI 1: Manhattan plot of Genome- Wide Association Study for NBA in LW_2 196 SI 2: Manhattan plot of...

Ngày tải lên: 26/11/2015, 10:18

... Deviance Information Criterion 4.1 Empirical likelihood based deviance information criterion 4.1.1 Deviance information criterion 4.1.2 Empirical likelihood based deviance information criterion ... Computation 2.1 Bayesian empirical likelihood and its non-convexity problem 2.2 Properties of log empirical likelihood 2.3 Hamiltonian Monte Carlo for Bayesian empiric...

Ngày tải lên: 09/09/2015, 08:17

... article as: Ferrigno et al.: Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors Analysis of acute toxicity Radiation Oncology 2010 5:117 Submit ... Elective radiotherapy with intensity modulated radiation therapy (IMRT) technique in the treatment of pelvic lymph nodes and primary tumor reg...

Ngày tải lên: 09/08/2014, 09:20

... detection techniques for multipleinput multiple- output systems As received signals of multiple- input multiple- output systems may contain much more severe interferences compared to single -input singleoutput ... REDUCED- COMPLEXITY SIGNAL PROCESSING TECHNIQUES FOR MULTIPLE- INPUT MULTIPLE- OUTPUT STORAGE AND WIRELESS COMMUNICATION SYSTMES LI HUANG...

Ngày tải lên: 14/09/2015, 14:12

... case (P-Hat) The median of the cumulative genetic risk in the case group is 0.90, and in the control group 0.01 Quantiles of the estimated cumulative genetic risk (PHat) using different genetic models ... accuracy in the independent dataset despite a median cumulative genetic risk in the discovery dataset of 0.90 for the case group, and 0.01 for the c...

Ngày tải lên: 11/08/2014, 12:21

... myeloid leukemia (CML), in a reverse way by blocking the activity of the fusion protein using the tyrosine-kinase inhibitory drug imatinib mesylate As shown in Table 1, ontological analysis of ... was the 'EGF receptor pathway', individual members of which are known to become phosphorylated/activated by BCR/ABL1 Taken together, these findings support the validity of the...

Ngày tải lên: 14/08/2014, 07:21

... feature selection methods confined to genome- wide association studies in Subsection Chapter1: Introduction 1.3.1 Model selection methods and some feature selection methods incorporated into model selection ... original SCAD method Chapter 3: Model selection criterion in generalized linear models 37 Chapter Model Selection Criteria in Generalized Linea...

Ngày tải lên: 11/09/2015, 16:05

... force and aerodynamic, for the rotating disk studied The general interests lie mainly in finding ways to increase the critical speeds and expand the stability region For instance, a higher rotating ... transverse load, it is necessary to apply a coordinate transformation to relate & the fixed frame and rotating frame, Δη = θ + ΩΔt Ω and Ω are the relative rotating sp...

Ngày tải lên: 16/09/2015, 15:43

... consequences for the overall performance of the system One key to reducing the cost of unification is to find the simplest set of operations that meet the needs of grammar writers but still can be efficiently ... disjunctive normal form (DNF) Of course, the ratio of the number of rules and lexical entries in the original g r a m m a r and the DNFed g r a m m a r depends on...

Ngày tải lên: 08/03/2014, 06:20