Development of human stem cell based model for developmental toxicity testing
Development of human stem cell based model for developmental toxicity testing
... toxicity 15 2.2.2 In vivo animal studies for developmental toxicity testing 17 2.3 In vitro animal -based models for developmental toxicity testing 18 2.3.1 The MM assay 19 2.3.2 ... However, current animal -based models for developmental toxicity testing is limited by time, cost and high inter-species variability, while human pluripotent stem cell (hPSC) mod...
Ngày tải lên: 09/09/2015, 08:18
A human embryonic stem cell based model of trophoblast formation
... Stem Cell Research (ISSCR) Conference 2007, Cairns Australia) A Human Embryonic Stem Cell based Model of Trophoblast Formation (manuscript in preparation, 2009) Inhibition of methylation releases ... (Carosella et al., 200 8a; Carosella et al., 2008b) Trophoblast cells are also able to avoid maternal natural killer cell monitoring and attacking independent of HLA...
Ngày tải lên: 11/09/2015, 16:07
báo cáo sinh học:" Empowering the people: Development of an HIV peer education model for low literacy rural communities in India" pdf
... VC and DS participated in the initial concept, the design of the study and the development of the IEC materials KVR assisted in data analysis and drafted the manuscript MR designed the monitoring ... subsequent training The duration of the training was six, four and two days for OW, PHE and barbers, respectively All trainings were performed in the native la...
Ngày tải lên: 18/06/2014, 17:20
Development of a generic three dimensional model for stratified flows
... flows Although two -dimensional models are Chapter computationally efficient and their results are generally reasonable, most practical applications generally require a full three- dimensional analysis ... Reynolds Averaged Navier-Stokes Equations The time averaged form of the Navier-Stokes equations are called the Reynolds Averaged 12 Chapter Navier-Stokes (RANS) equations These mo...
Ngày tải lên: 04/10/2015, 15:46
Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx
... observation of the first colonies in hematopoietic colony assays [55 ] The hematopoietic transcription factors SCL and GATA-2 were also expressed in these cells between days and 21 of differentiation ... indicated that the placenta acts as an additional extramedullary hematopoietic organ during embryonic and fetal development [52 ,53 ] Hematopoietic precursors found...
Ngày tải lên: 22/03/2014, 17:20
development of new human stem cell derived cellular vehicles for glioma gene therapy
... DEVELOPMENT OF NEW HUMAN STEM CELLDERIVED CELLULAR VEHICLES FOR GLIOMA GENE THERAPY ZHAO YING (B Sc., PKU; M Sc., PKU) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... stem cells by adherent monoculture 4.3.2 “Stemness” of human embryonic stem cell- derived neural 127 stem cells 4.3.3 In vitro glioma tropism evaluation o...
Ngày tải lên: 11/09/2015, 09:00
Development of new neural stem cell based tumor targeted gene therapy approaches
... DEVELOPMENT OF NEW NEURAL STEM CELL- BASED TUMOR- TARGETED GENE THERAPY APPROACHES ZHU DETU (B Sc.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOLOGICAL ... study aims to develop new NSC -based tumor- targeted gene therapy that improves the treatment of patients with breast cancer and overcomes the hurdles faced by stem...
Ngày tải lên: 09/09/2015, 10:06
Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... they form compact colonies and exhibit severe defects in cell proliferation without precocious differentiation Our data clearly demonstrate that PTB is essential for mouse development and ES cell ... PTB in development and ES cells M Shibayama et al are what the identity is of the target protein regulated by PTB in the mitotic phase and how this target protein...
Ngày tải lên: 07/03/2014, 00:20
báo cáo hóa học:" Use of a novel cell-based fusion reporter assay to explore the host range of human respiratory syncytial virus F protein" ppt
... observed was attributable to the HRSV F protein Host range of HRSV-mediated fusion To determine the host range of HRSV F mediated fusion using the quantitative fusion assay 293T effector cells ... interpretation The assay described herein is a means of quantifying the fusion activity of the HRSV F protein This assay has multiple applicatio...
Ngày tải lên: 20/06/2014, 04:20
Báo cáo hóa học: "Research Article A Geometrical-Based Model for Cochannel Interference Analysis and Capacity Estimation of CDMA Cellular Systems" pot
... sectorization and BS antenna radiation pattern has also been studied Cells sectorization and use of narrow beam BS antennas increase Konstantinos B Baltzis significantly the capacity of a cellular ... Mediterranean Microwave Symposium, pp 1–5, Budapest, Hungary, July 2007 [20] I A Aldmour, K Al-Begain, and A I Zreikat, “Uplink capacity/ coverage analysis of WCDMA with...
Ngày tải lên: 21/06/2014, 23:20
báo cáo khoa học: "Development of a primary care-based complex care management intervention for chronically ill patients at high risk for hospitalization: a study protocol" potx
... as well as care organization contributes to avoidable hospitalizations and to what extent care management may be able to implement strategies that target the revealed mechanisms As implementation ... development of a complex HCA-led care management intervention for chronically ill patients that aims to implement strategies to reduce avoidable hospitalizations in Germ...
Ngày tải lên: 10/08/2014, 10:23
báo cáo khoa học: "Current status of haploidentical stem cell transplantation for leukemia" pps
... Feasibility and outcome of reduced intensity conditioning in haploidentical transplantation Ann NY Acad Sci 2007, 1106:279-289 Dey BR, Spizer TR: Current status of haploidentical stem cell transplantation ... engraftment after haploidentical stem cell transplantation Leukemia 2004, 18:1835-1838 Passweg JR, Stern M, Koehl U, et al.: Use of natural killer cells in he...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx
... al.: Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice Journal of Nanobiotechnology ... procedure ensured the systemic incorporation of growth factor into the nanoparticles instead of adsorption Nanoparticles having the...
Ngày tải lên: 11/08/2014, 00:23
Báo cáo y học: " Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2" pps
... Tax1 (18 5 -19 1) Tax1 (19 8-207) Tax207 Figure The Tax1 (18 5-207) region negatively regulates the transforming activity of Tax1 The Tax1 (18 5-207) region negatively regulates the transforming activity ... http://www.retrovirology.com/content/6 /1/ 83 Iwanaga Y, Tsukahara T, Ohashi T, Tanaka Y, Arai M, Nakamura M, Ohtani K, Koya Y, Kannagi M, Yamamoto N, Fujii...
Ngày tải lên: 12/08/2014, 23:22
Báo cáo y học: " PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line" ppsx
... http://www.retrovirology.com/content /2 /1/ 46 Tax1 Tax C Tax3 5 1A Tax3 5 3A Vec Tax2 B Tax2 B+C B Exp .1 % qPositive qwells 40 Exp .2 30 20 10 Vec Tax1 Tax C Tax3 5 1A Tax3 5 3A Tax2 B Tax2 B+C Figure PBM is essential for outgrowth ... of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1 Oncogene 19 96, 12 :16 45 -16 52 Mori N,...
Ngày tải lên: 13/08/2014, 09:21