Epigenetic regulation of normal and malignant hematopoiesis

... in normal hematopoiesis and leukemia The methylation of histones on lysine and arginine residues by HMTs represents another level of gene regulation, and is probably the most complex of the epigenetic ... silencing (Cao et al., 2005) Oncogene Epigenetic regulation of hematopoiesis KL Rice et al 6704 Table Substrate specificity of HKMTs and involvement of norma...

Ngày tải lên: 05/09/2015, 11:25

... homocysteine to methionine Tissue metabolism of arginine and methionine is of high importance for the effective regulation of cell death and survival in normal as well as in tumor cells Polyamines ... expression of different enzymes involved in arginine and methionine metabolism because these enzymes are intimately related to creatine biosynthesis (...

Ngày tải lên: 07/03/2014, 04:20

... (NSRA), including the Guide to Navigating through the Northern Sea Route (NSR Navigation Guide) and the Requirements for the Design, Equipment and Supplies of Vessels Navigating the Northern Sea Route ... adjoining the USSR northern coast and that it includes seaways suitable for guiding vessels in ice Due to the vagueness concerning leading in Artic...

Ngày tải lên: 01/11/2013, 09:20

... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an ... analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target...

Ngày tải lên: 16/02/2014, 09:20

... We used iTRAQ labeling together with gel-assisted digestion and mass spectrometry to detect differences in the protein expression profiles of membrane fractions from tumoral and adjacent normal ... tags with related and absolute quantitation (iTRAQ) labeling and LC-MS ⁄ MS for quantitative analysis of the membrane proteome of colorectal tissue In brief...

Ngày tải lên: 16/02/2014, 15:20

... 2675 Actin and ABPs in transcription regulation B Zheng et al Table Role of nuclear actin- binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain ... STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates actin- binding in several proteins,...

Ngày tải lên: 07/03/2014, 01:20

... Htt-interacting protein HIP -1 and its molecular partner HIPPI in the regulation of apoptosis and transcription, the two processes that are altered in HD [7,8] HIP -1 – its interacting partners and ... Conclusions HIP -1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor...

Ngày tải lên: 23/03/2014, 07:20

... containing galactose as a carbon source Wild-type and mrg19 strains grew on galactose plates within 12 h while gal3 strain showed the characteristic delay in growth on galactose Interestingly, the ... disruption of MRG19 might effect GAL induction only at low galactose concentrations This hypothesis was tested by monitoring galactokinase induction as a function of...

Ngày tải lên: 31/03/2014, 08:20

... support of the trunk, in mid-stance gastrocnemius increases the stance leg energy and restrains the forward motion of the trunk; soleus has the opposite effects In late stance, the initiation of swing ... regarding the role of the plantarflexors in propulsion, but their study examined the accelerations of the hip rather than the trunk COM [40] Dynamic s...

Ngày tải lên: 19/06/2014, 10:20

... band at ∼1,650 cm 󰠏1 Table Spectral data and vibrational assignments of normal and lung cancer cells* Normal cells † (NHBE ) Cancer cells (NCI-H358) Cancer cells (NCI-H460) 1,649 1,548 1,456 1,400 ... lung cancer cells The NCI-H460 lung cancer cells originated from a patient with large cell cancer of the lung (ATCC catalog number: HTB-177), which...

Ngày tải lên: 07/08/2014, 23:22

... compared the effects of VIP, rolipram, and dibutyryl cAMP on the production of TNF-α and IL-10 by monocytes Spontaneous production of IL-10 and TNF-α by monocytes could not be detected; cytokine ... macrophage IL-10 production We wished to investigate VIP regulation of cAMP levels in monocytes and macrophages upon stimulation by LPS and PMA/ionomycin...

Ngày tải lên: 09/08/2014, 01:23

... review of naturally occurring human OA and experimental canine OA and from the results of a preliminary caninespecific whole genome microarray study, using a small number of samples Assays were ... quantification of expression of five collagen genes (type I collagen, alpha chain [COL1A2], type II collagen alpha chain [COL2A1], type III collagen alpha chain [COL3A1], ty...

Ngày tải lên: 09/08/2014, 08:22

... inverted pattern of utilization of NFκB for the T-cell contact-dependent induction of CC and CXC chemokines in monocytes is surprising and indicates that chemokine gene expression may be more complex ... same system of adenovirally mediated IκBα overexpression in M-CSF-differentiated monocytes to investigate the potential involvement of NFκB in the expressi...

Ngày tải lên: 09/08/2014, 08:23

... dorsal horn neurons [14,15] In order to study the contribution of glial activation and the associated upregulated expression of IL-1β on spinal cord nociceptive transmission in arthritic rats, we used ... inflammation and damage of peripheral tissues, the spinal cord responds with a robust glial reaction characterized by proliferation, hypertrophy, decreased ramif...

Ngày tải lên: 09/08/2014, 14:22

... strict -maternal, mostly -maternal, maternal- zygotic and mostly -zygotic, respectively) Strikingly, the 5' IGR lengths of the small set of 282 genes belonging to the strict -zygotic class are extremely ... regulatory architecture of maternal and zygotic genes across the animal kingdom highlights the complexity of regulation of mammalian maternal genes To analyze the...

Ngày tải lên: 09/08/2014, 20:22