... 1685 Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 Adaoha E. C. Ihekwaba1,4, Stephen J. Wilkinson1, Dominic ... method of analysis (in vitro, cell-based and in silico analysis) will facilitate systematic understanding of the underlying properties of this signaling pathway. To summarizeActivation of cells ... that the inhibition of IKK2 blocksresponse in vitro. Despite the fact that IKK2 has beenidentified as a key participant in the NF-jB signaling pathways, both our cell-based and in silico studies revealed...